DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment BBS4 and CG31690

DIOPT Version :9

Sequence 1:	NP_149017.2	Gene:	BBS4 / 585	HGNCID:	969	Length:	519	Species:	Homo sapiens
Sequence 2:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	96/472 - (20%)
Similarity:	165/472 - (34%)	Gaps:	141/472 - (29%)

- Green bases have known domain annotations that are detailed below.

Human    75 LIFRLEGNIQESLELFQTCAVLSPQSADNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISH 139
            |:.||.||         :|......:.|...|::..     .:::|..:|:.::|.....|..:.
  Fly   368 LLRRLGGN---------SCHTWLGLTCDCHHQLSAP-----SYRSASAIYSTSSKSKSASWTAAP 418

Human   140 NLGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTEL 204
            .||..::.| .|..|.:.|..        :.::|..::            :|..:|.:.     |
  Fly   419 ILGTAFLVL-PFLPASNLLFY--------VGFVMAERV------------LYLPSVGYC-----L 457

Human   205 LTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAILAAG--SMMQTHGDFDVALTKYR------- 260
            |..||            |.||...:. .....:.:|..|  .::..||     :..:|
  Fly   458 LFGLG------------FGHLWQRVN-SSWRSRLMLLCGLALLLGVHG-----VRTFRRNLDWRD 504

Human   261 ---VVACAVPESPP-LWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYA 321
               :...|:..:|| ...|:|.....:.:|..|...|:......|......:|||:||.....::
  Fly   505 EEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFS 569

Human   322 SAFHFLSAAINFQPKMGELYMLLAVALTNLED--------------IENA----KRAYAEAVHLD 368
            ||......||..:|::...|:.|..:|.:|.|              :|.:    :.|:.||.:
  Fly   570 SAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARY-- 632

Human   369 KCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLL--KDNSSLEF----------DSEMVEMA 421
            .|    .|..:||..:.|..::|.|..:|..|.:.||  |..:.|..          |....|..
  Fly   633 TC----YLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQ 693

Human   422 QKLGAALQ--------------------VGEALVWTK------PVKDPKSKHQTTSTSKPASF-Q 459
            |:|...||                    :.||..|.|      |: :|.|.|..      |.| :
  Fly   694 QRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPL-EPSSHHHY------ADFLE 751

Human   460 QPLGSNQALGQAMSSAA 476
            |....::|||..:.:||
  Fly   752 QQERHHEALGLRLRAAA 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
BBS4	NP_149017.2	Required for localization to centrosomes	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		TPR_11	<18..400	CDD:330823	69/355 (19%)
		TPR repeat	36..61	CDD:276809
		TPR 1	67..100		6/24 (25%)
		TPR repeat	68..95	CDD:276809	6/19 (32%)
		Interaction with PCM1. /evidence=ECO:0000269\|PubMed:15107855	101..337		46/248 (19%)
		TPR repeat	101..129	CDD:276809	4/27 (15%)
		TPR repeat	134..164	CDD:276809	7/29 (24%)
		TPR repeat	169..196	CDD:276809	2/26 (8%)
		TPR repeat	202..229	CDD:276809	7/26 (27%)
		TPR repeat	236..264	CDD:276809	5/39 (13%)
		TPR repeat	270..298	CDD:276809	7/28 (25%)
		TPR repeat	303..333	CDD:276809	9/29 (31%)
		Required for localization to centrosomes	338..519		44/196 (22%)
		TPR repeat	338..365	CDD:276809	8/44 (18%)
		TPR repeat	372..397	CDD:276809	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	440..519		11/38 (29%)
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594
		TPR_11	518..583	CDD:290150	16/64 (25%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	551..581	CDD:276809	9/29 (31%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	49/217 (23%)
		TPR repeat	586..611	CDD:276809	5/24 (21%)
		TPR repeat	634..660	CDD:276809	8/29 (28%)
		TPR repeat	671..699	CDD:276809	5/27 (19%)
		TPR repeat	704..735	CDD:276809	4/30 (13%)
		TPR repeat	740..768	CDD:276809	9/33 (27%)
		TPR repeat	773..803	CDD:276809
		TPR	808..841	CDD:197478
		TPR repeat	808..836	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810