DRSC/TRiP Functional Genomics Resources

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Protein Alignment BBS4 and CG4341

DIOPT Version :9

Sequence 1:NP_149017.2 Gene:BBS4 / 585 HGNCID:969 Length:519 Species:Homo sapiens
Sequence 2:NP_608558.1 Gene:CG4341 / 33276 FlyBaseID:FBgn0028481 Length:938 Species:Drosophila melanogaster


Alignment Length:437 Identity:87/437 - (19%)
Similarity:156/437 - (35%) Gaps:107/437 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    30 PILEKQNWLIHLHYIRKD---------------YEACKAVIKEQLQETQGLCEYAIYVQALIFR- 78
            |.|...|.|.::.::..:               |...|.:...|......|..:::.:.|:..| 
  Fly   515 PFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRT 579

Human    79 LEGNI--QESLELFQTCAVLSPQSA-DNLKQVARSLFLLGKHKAAIEVYNEAAKLNQKDWEISHN 140
            |..|.  ::...|:::...::|..| .||..|..|   .|:::.|.:|..||.:......::..|
  Fly   580 LRRNADWRDEESLYRSAIAINPPKALGNLGSVLSS---QGRYEEAKQVLQEAIRFRPNMADVHFN 641

Human   141 LGVCYIYLKQFNKAQDQLHNALNLNRHDLTYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELL 205
            ||:                    |:::...|             ..|:|.:::|::|.|......
  Fly   642 LGI--------------------LHQNQQVY-------------PAAVECFQRAIKFRPNLAVAY 673

Human   206 TTLGLLYLQLGIYQKAFEHL-------GNAL----TYDPTNYKAILAAGSMMQTHGDFDVALTKY 259
            ..||:.::.||..|:|.|.|       |.|:    .:|.....|.|..|::....|....||..|
  Fly   674 LNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIY 738

Human   260 RVVACAVPESPP----LWNNIGMCF-------FGKKKYVAAISC--------------------- 292
            |....::|..|.    |:..||...       ..::.:.||:..                     
  Fly   739 REALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNSSR 803

Human   293 -------LKRANYLAPFDWKILYNLG-LVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALT 349
                   .|||..|||....:.::.. .:.|..:.:.||.:...|| ...|....|.:..|.|:.
  Fly   804 ASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAA-ELAPNDYTLVVAAATAMR 867

Human   350 NLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQ 396
            .|:...:|:..|.:||.|...:...:.|...:|:..|...:|.|.|:
  Fly   868 LLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYK 914

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BBS4NP_149017.2 Required for localization to centrosomes 1..66 7/50 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..25
TPR_11 <18..400 CDD:330823 87/437 (20%)
TPR repeat 36..61 CDD:276809 5/39 (13%)
TPR 1 67..100 6/35 (17%)
TPR repeat 68..95 CDD:276809 5/29 (17%)
Interaction with PCM1. /evidence=ECO:0000269|PubMed:15107855 101..337 58/287 (20%)
TPR repeat 101..129 CDD:276809 10/28 (36%)
TPR repeat 134..164 CDD:276809 3/29 (10%)
TPR repeat 169..196 CDD:276809 4/26 (15%)
TPR repeat 202..229 CDD:276809 9/33 (27%)
TPR repeat 236..264 CDD:276809 8/27 (30%)
TPR repeat 270..298 CDD:276809 9/66 (14%)
TPR repeat 303..333 CDD:276809 5/30 (17%)
Required for localization to centrosomes 338..519 15/59 (25%)
TPR repeat 338..365 CDD:276809 6/26 (23%)
TPR repeat 372..397 CDD:276809 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 440..519
CG4341NP_608558.1 PMT_2 112..>232 CDD:304453
DUF1736 275..343 CDD:285594
TPR_11 602..667 CDD:290150 19/100 (19%)
TPR_1 602..634 CDD:278916 10/34 (29%)
TPR repeat 602..630 CDD:276809 10/30 (33%)
TPR repeat 635..665 CDD:276809 8/62 (13%)
TPR_11 636..700 CDD:290150 18/96 (19%)
TPR_1 636..668 CDD:278916 9/64 (14%)
TPR repeat 670..694 CDD:276809 7/23 (30%)
TPR_11 714..784 CDD:290150 15/69 (22%)
TPR repeat 715..743 CDD:276809 8/27 (30%)
TPR repeat 748..782 CDD:276809 6/33 (18%)
TPR_11 755..819 CDD:290150 9/63 (14%)
TPR repeat 787..816 CDD:276809 3/28 (11%)
TPR_11 821..887 CDD:290150 15/66 (23%)
TPR repeat 822..850 CDD:276809 5/28 (18%)
TPR repeat 855..885 CDD:276809 8/29 (28%)
TPR_11 <874..921 CDD:290150 11/41 (27%)
TPR repeat 890..918 CDD:276809 6/25 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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