DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAM2 and tutl

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_001303307.1	Gene:	tutl / 46015	FlyBaseID:	FBgn0010473	Length:	1536	Species:	Drosophila melanogaster

Alignment Length:	262	Identity:	63/262 - (24%)
Similarity:	110/262 - (41%)	Gaps:	54/262 - (20%)

- Green bases have known domain annotations that are detailed below.

Human     3 RRSRHRL-------------------LLLLLRYLVV---ALGYHKAYGFSAPKDQQVVTAVEYQE 45
            ||||.|.                   .:.:|::::|   ||....|...:.|:|...:||:..:.
  Fly    81 RRSRRRAEGSSICVPIRRGQGSTPTPTIQVLQFVLVSLLALLAKNAQAHNIPEDAVHITAILGEG 145

Human    46 AILACKTP---KKTVSSRLEW-KKLGRSVS----FVYYQ---QTLQGDFKNRAEMI-------DF 92
            .|..|...   ...|...|:| ||:..:.|    :::|:   :.::..:|.|...:       ..
  Fly   146 VIFNCHVEFPNDHPVPYVLQWDKKVSETGSDLPIYIWYESYPEHIEEGYKGRVSRVSQDSPFGSA 210

Human    93 NIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDT-VTLEVLVAP--AVPSCEVPSSALSGTVVELR 154
            ::.:.|:..||.|.|.|:|...:...:..:..| ..|:|...|  :|...::....|..::: |.
  Fly   211 SLNLTNIRESDQGWYECKVVFLNRDPKQHKNGTWFHLDVHAPPRFSVTPEDIIYVNLGDSII-LN 274

Human   155 CQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNS 219
            || .:|.|.||..|:||...:..:|.:|        ..|..| .|:.:|:...|.|||:|.|||.
  Fly   275 CQ-ADGTPTPEILWYKDANPVDPSPTVG--------IFNDGT-ELRISTIRHEDIGEYTCIARNG 329

Human   220 VG 221
            .|
  Fly   330 EG 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	22/113 (19%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	25/71 (35%)
tutl	NP_001303307.1	V-set	137..250	CDD:284989	22/112 (20%)
		IG_like	137..229	CDD:214653	19/91 (21%)
		I-set	253..341	CDD:254352	28/90 (31%)
		IGc2	268..331	CDD:197706	24/73 (33%)
		I-set	346..437	CDD:254352
		Ig	349..437	CDD:299845
		Ig	459..530	CDD:299845
		IG_like	549..628	CDD:214653
		IGc2	551..617	CDD:197706
		FN3	633..725	CDD:238020
		FN3	786..874	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910