DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAM2 and hbs

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_001286439.1	Gene:	hbs / 44129	FlyBaseID:	FBgn0029082	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	207	Identity:	53/207 - (25%)
Similarity:	91/207 - (43%)	Gaps:	43/207 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    32 PKDQQVVTAVEYQEAILACKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMID----- 91
            |.|.|:   :|..:.:|.|:...:  :.:::|.|.|.::.|   ...:.| |...:.::|
  Fly    45 PHDLQI---LEGTDTLLRCEVSNR--AGKVQWTKDGFALGF---SAVIPG-FPRYSVLVDAKQNA 100

Human    92 FNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPSCEVPSSALSGTV------ 150
            :|::|||.|..|..:|:|:|...:  |.........|.::.||:  |..:...|.:..|
  Fly   101 YNLQIKNATLEDDAEYQCQVGPAA--GNPAIRANAKLSIVAAPS--SIVIEGYARNARVEVEERQ 161

Human   151 -VELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKL------- 207
             :.|.|..:..|||.|..||:..:.:         ||....|:| :|...:|.|.|.|
  Fly   162 NLTLHCIAENANPAAEIVWFQGEVPV---------STAPIVTVN-QTAPKRFTTSSTLHLQPRAE 216

Human   208 -DTGEYSCEARN 218
             |..|:|||||:
  Fly   217 DDYKEFSCEARH 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	22/99 (22%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	24/76 (32%)
hbs	NP_001286439.1	Ig	44..122	CDD:299845	22/85 (26%)
		IG_like	45..137	CDD:214653	24/102 (24%)
		Ig	153..231	CDD:299845	25/86 (29%)
		IG_like	258..342	CDD:214653
		Ig	266..327	CDD:299845
		IG_like	357..>414	CDD:214653
		Ig	360..427	CDD:299845
		Ig	<468..526	CDD:299845
		I-set	547..633	CDD:254352
		Ig	556..631	CDD:299845
		I-set	644..735	CDD:254352
		IGc2	668..725	CDD:197706
		IG_like	751..829	CDD:214653
		IGc2	753..815	CDD:197706
		Ig	852..928	CDD:143165
		FN3	935..1017	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910