DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAM2 and plum

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_001163744.1	Gene:	plum / 43197	FlyBaseID:	FBgn0039431	Length:	1298	Species:	Drosophila melanogaster

Alignment Length:	218	Identity:	55/218 - (25%)
Similarity:	84/218 - (38%)	Gaps:	37/218 - (16%)

- Green bases have known domain annotations that are detailed below.

Human    32 PKDQQVVTAVEYQEAILACKTPKKTV------SSRLEWKKLGRSVSFVYYQQTLQGDFKNRA-EM 89
            ||::..:|.....||.|.......||      |..|:...:...|..|:|.|.........: ..
  Fly   260 PKNEAGITETAVSEAQLLPAFQNATVFVPAGGSVLLQCHAVADFVPIVWYLQPPNNKMVRLSNNS 324

Human    90 IDFNIRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAPAVPS---CEVPSSALSGTVV 151
            :.::|...::.|.: |:|.|...        ||.....:.|...|.:.|   .||....||.|
  Fly   325 VAYSITNASIARHE-GRYSCITP--------LETQNFQVIVTTPPRIVSRLPVEVVYIGLSRT-- 378

Human   152 ELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEA 216
             |.|: .||:|.|..||:.:|:.|           |||||.......|..::....:.|.|.|.|
  Fly   379 -LTCR-AEGHPEPSITWYHNGVHL-----------NSSYTRYISGNELHVHSFDSKEEGIYQCVA 430

Human   217 RNSVGYRRCPGK---RMQVDDLN 236
            ||..|.....|:   ..|::::|
  Fly   431 RNVAGEDSATGELRFNRQLEEVN 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	19/101 (19%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	23/73 (32%)
plum	NP_001163744.1	IG_like	170..241	CDD:214653
		IGc2	175..235	CDD:197706
		IG_like	284..356	CDD:214653	15/80 (19%)
		I-set	360..443	CDD:254352	31/97 (32%)
		IGc2	378..435	CDD:197706	23/71 (32%)
		FN3	804..886	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910