DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment JAM2 and otk

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_523705.2	Gene:	otk / 36283	FlyBaseID:	FBgn0004839	Length:	1033	Species:	Drosophila melanogaster

Alignment Length:	323	Identity:	75/323 - (23%)
Similarity:	127/323 - (39%)	Gaps:	92/323 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    30 SAPKDQQVVTAVEY----------QEAILA---CKTPKKTVSSRLEWKKLGRSVSFVYYQQTLQG 81
            |:|...:|:..:::          .:|::|   ||. :.|.:.:::|.:.|.:.:...:.:
  Fly   366 SSPGILEVIEQLKFVPQPTSKNLELDAVVAKVHCKA-QGTPTPQVQWVRDGENTTLPDHVE---- 425

Human    82 DFKNRAEMIDFN--IRIKNVTRSDAGKYRCEVSAPSEQGQNLEEDTVTLEVLVAP--AVPSCEVP 142
                    :|.|  :..:||.....|.|.|  .|.:.|||  ...||.:.|:|.|  :||.....
  Fly   426 --------VDANGTLIFRNVNSEHRGNYTC--LATNSQGQ--INATVAINVVVTPKFSVPPVGPI 478

Human   143 SSALSGTVVELRCQDKEGNPAPEYTWFKDGIRLLENPRLGSQSTNSSYTMNTKTGTLQFNTVSKL 207
            .::..|||| :.|| ..|:|.|...|.||...|.||      :|:.......:.|||:...|...
  Fly   479 ETSEQGTVV-MHCQ-AIGDPKPTIQWDKDLKYLSEN------NTDRERFRFLENGTLEIRNVQVE 535

Human   208 DTGEYSCEARNSVGYRRCPGKRMQVDDLNI-------------SG----------IIAAVVVVAL 249
            |.|.|.|...||.|.:|        :|:.:             ||          :|...|.:|.
  Fly   536 DEGSYGCTIGNSAGLKR--------EDVQLVVKTTGDGFAPEESGGDGFLVTRAVLITMTVALAY 592

Human   250 VISVCGLGV-CYAQRKGYFSKETSFQKSNSSSKATTMSENVQWLTPVIPALWKAAAGGSRGQE 311
            ::.|.||.: |..:|:.        :|:..:..:|..:...|   |.:       ||..:|.|
  Fly   593 IVLVVGLMLWCRYRRQA--------RKARLNDLSTKEAGGDQ---PDV-------AGNGKGSE 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	21/109 (19%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	24/73 (33%)
otk	NP_523705.2	I-set	26..115	CDD:254352
		Ig	31..115	CDD:299845
		IGc2	133..195	CDD:197706
		Ig	268..373	CDD:299845	2/6 (33%)
		Ig	395..460	CDD:143165	17/81 (21%)
		I-set	468..559	CDD:254352	32/106 (30%)
		IGc2	484..549	CDD:197706	26/72 (36%)
		PTK_CCK4	686..1026	CDD:133178
		STYKc	692..1020	CDD:214568
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910