DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAM2 and DIP-eta

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_001188701.2	Gene:	DIP-eta / 33793	FlyBaseID:	FBgn0031725	Length:	450	Species:	Drosophila melanogaster

Alignment Length:	214	Identity:	52/214 - (24%)
Similarity:	87/214 - (40%)	Gaps:	55/214 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    29 FSAPKDQQVV--TAVEYQEAILACKT----PKKTVSSRLEWKKLGRSVSFVYYQQTLQGDF--KN 85
            ||:|    :|  ||...::|.|.|..    |.|....|::.:.:          .|:|...  ||
  Fly    45 FSSP----IVNMTAPVGRDAFLTCVVQDLGPYKVAWLRVDTQTI----------LTIQNHVITKN 95

Human    86 R------AEMIDFNIRIKNVTRSDAGKYRCEVSA---PSEQGQNLEEDTVTLEVLVAPAVPSCEV 141
            :      :|...:.:|||::..||.|.|.|:::.   .|:.|.        |:|:|.|.:  .:.
  Fly    96 QRIGIANSEHKTWTMRIKDIKESDKGWYMCQINTDPMKSQMGY--------LDVVVPPDI--LDY 150

Human   142 PSS----ALSGTVVELRCQDKEGNPAPEYTWFKD-GIRLLENPRLGSQSTNSSYTMNTKTGTLQF 201
            |:|    ...|:.|.|:|. ..|:|.|..||.:: |:.:        :.......|:.:...|..
  Fly   151 PTSTDMVVREGSNVTLKCA-ATGSPEPTITWRRESGVPI--------ELATGEEVMSIEGTDLVI 206

Human   202 NTVSKLDTGEYSCEARNSV 220
            ..|.:...|.|.|.|.|.|
  Fly   207 PNVRRHHMGAYLCIASNGV 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	25/111 (23%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	18/71 (25%)
DIP-eta	NP_001188701.2	Ig	51..141	CDD:299845	24/107 (22%)
		IG_like	51..137	CDD:214653	22/95 (23%)
		IG_like	153..237	CDD:214653	20/82 (24%)
		Ig	161..224	CDD:299845	17/71 (24%)
		IG_like	252..335	CDD:214653
		Ig	258..333	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910