DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment JAM2 and DIP-beta

DIOPT Version :9

Sequence 1:	NP_001257337.1	Gene:	JAM2 / 58494	HGNCID:	14686	Length:	312	Species:	Homo sapiens
Sequence 2:	NP_001138225.1	Gene:	DIP-beta / 33125	FlyBaseID:	FBgn0259245	Length:	555	Species:	Drosophila melanogaster

Alignment Length:	325	Identity:	71/325 - (21%)
Similarity:	128/325 - (39%)	Gaps:	54/325 - (16%)

- Green bases have known domain annotations that are detailed below.

Human     6 RHRLLLLLLRYLVVALGYHKAYG--------FSAPKDQQVVTAVEYQEAILACKTPK-------- 54
            |.:||||||....:.|.......        |..|.:.  ||..:.::|...|....
  Fly    69 RWQLLLLLLLGNCIDLTVSNKISSVGAFEPDFVIPLEN--VTIAQGRDATFTCVVNNLGGHRVSG 131

Human    55 --KTVSSRLEWKKLGRSVSFVYYQQTLQGDFKNRAEMIDFN---IRIKNVTRSDAGKYRCEVSAP 114
              .:..:::.|.|.........::..:..:.:...:..|:|   :.|:.|...|||||.|:|:.
  Fly   132 DGSSAPAKVAWIKADAKAILAIHEHVITNNDRLSVQHNDYNTWTLNIRGVKMEDAGKYMCQVNT- 195

Human   115 SEQGQNLEEDTVTLEVLVAPAVPSCEVPSSAL--SGTVVELRCQDKEGNPAPEYTWFK-DGIRLL 176
                ..::..|.||||::.|.:.:.|.....:  .|...:|.|:.: |:|.|:.||.: ||..::
  Fly   196 ----DPMKMQTATLEVVIPPDIINEETSGDMMVPEGGSAKLVCRAR-GHPKPKITWRREDGREII 255

Human   177 ENPRLGSQSTNSSYTMNTKTGTLQFNTVSKLDTGEYSCEARNSVGYRRCP---GKRMQVDD---- 234
              .|.||.....:.::..:..||  :.:::.:.|.|.|.|.|.|     |   .|||::..
  Fly   256 --ARNGSHQKTKAQSVEGEMLTL--SKITRSEMGAYMCIASNGV-----PPTVSKRMKLQVHFHP 311

Human   235 -LNISGIIAAVVVVALVISVCGLGVCYAQRK--GYFSKETSFQKSNSSSKATTMSENVQWLTPVI 296
             :.:...:....|:..|..:|.:   .|..|  .|:.:|...........|.|..||..:...:|
  Fly   312 LVQVPNQLVGAPVLTDVTLICNV---EASPKAINYWQRENGEMIIAGDRYALTEKENNMYAIEMI 373

Human 297 296
Fly 374 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
JAM2	NP_001257337.1	IG_like	35..130	CDD:214653	20/107 (19%)
JAM2	NP_001257337.1	Ig	151..225	CDD:319273	20/74 (27%)
DIP-beta	NP_001138225.1	I-set	98..209	CDD:254352	24/117 (21%)
		ig	102..195	CDD:278476	18/94 (19%)
		IG_like	219..307	CDD:214653	25/97 (26%)
		Ig	221..307	CDD:299845	25/95 (26%)
		Ig	311..404	CDD:299845	12/66 (18%)
		IG_like	327..405	CDD:214653	11/50 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910