DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ZNF71 and znf526

DIOPT Version :9

Sequence 1:	NP_001357144.1	Gene:	ZNF71 / 58491	HGNCID:	13141	Length:	549	Species:	Homo sapiens
Sequence 2:	NP_001120164.1	Gene:	znf526 / 100145203	XenbaseID:	XB-GENE-5881673	Length:	919	Species:	Xenopus tropicalis

Alignment Length:	457	Identity:	174/457 - (38%)
Similarity:	246/457 - (53%)	Gaps:	47/457 - (10%)

- Green bases have known domain annotations that are detailed below.

Human   135 CHELKAFANQGCVL-----------VP-PRLDDP-----------TEKGACPPVRRGKNFSSTSD 176
            ||..|.|:|....|           || |:.:.|           ||:.|..|   ...| .|:|
Frog   399 CHCGKTFSNMTKFLYHRRTHAGKSGVPTPKTEKPIVTEMPVSPVLTEQTAASP---SVTF-QTAD 459

Human   177 LSK--------------PPMPCEEK-----KTYDCSECGKAFSRSSSLIKHQR-IHTGEKPFECD 221
            ||.              ||:..:.:     :::.|..|.|.||....:::|:| :|..|...:|.
Frog   460 LSPVLTKCQVNGVVKNIPPLEAQSEVRLTVQSFKCPVCSKEFSTRLRMVRHKRVVHAVELKHKCT 524

Human   222 TCGKHFIERSSLTIHQRVHTGEKPYACGDCGKAFSQRMNLTVHQRTHTGEKPYVCDVCGKAFRKT 286
            .|||||.::..|..|.|.||||:|:.|.|||||:....:|..|..||||.|||.||:|||.|.:.
Frog   525 VCGKHFKQKVHLQNHMRTHTGERPFQCTDCGKAYRSISSLRCHHLTHTGVKPYACDLCGKGFTQK 589

Human   287 SSLTQHERIHTGEKPYACGDCGKAFSQNMHLIVHQRTHTGEKPYVCPECGRAFSQNMHLTEHQRT 351
            |:|.||..:|||...:.|..||..|::...|.:|.|.|||...|.|.|||::|.:...|..|:..
Frog   590 SNLKQHRTLHTGASLFPCEVCGMKFNRASKLTLHLRAHTGALTYKCTECGKSFMRKELLELHRLG 654

Human   352 HTGEKPYACKECGKAFNKSSSLTLHQRNHTGEKPYVCGECGKAFSQSSYLIQHQRFHIGVKPFEC 416
            |.|::|..|.||...|.:.|.|..|:.:...|..|||..|||..:..:.||.|...|...:||.|
Frog   655 HQGKEPLHCHECAMVFEEESQLAEHKCHSNNEGQYVCPNCGKKLNSKTSLILHLLVHSDQRPFRC 719

Human   417 SECGKAFSKNSSLTQHQRIHTGEKPYECYICKKHFTGRSSLIVHQIVHTGEKPYVCGECGKAFSQ 481
            ..|||.|.....:.:|||.|:.::.::|.||.|.|....:|.:||.:||||:|:.|.:|||||.|
Frog   720 QVCGKCFPSQRRVQRHQRWHSAKRAHQCEICGKSFLASFNLRLHQRIHTGERPFPCPDCGKAFRQ 784

Human   482 SAYLIEHQRIHTGEKPYRCGQCGKSFIKNSSLTVHQRIHTGEKPYRCGECGKTFSRNTNLTRHLR 546
            :.:|.||.|:||||:||.|..|||:|:::..||.|:.:|||::|:.|.||||:|...:||..|.:
Frog   785 TTHLREHYRLHTGERPYHCQDCGKTFVQSMHLTEHRHLHTGQRPHSCTECGKSFKTVSNLRSHRK 849

Human   547 IH 548
            .|
Frog   850 TH 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF71	NP_001357144.1	KRAB	13..54	CDD:334504
		C2H2 Zn finger	168..184	CDD:275368	7/29 (24%)
		COG5048	170..544	CDD:227381	158/393 (40%)
		C2H2 Zn finger	192..212	CDD:275368	7/20 (35%)
		C2H2 Zn finger	220..240	CDD:275368	9/19 (47%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	10/19 (53%)
		C2H2 Zn finger	304..324	CDD:275368	7/19 (37%)
		C2H2 Zn finger	332..352	CDD:275368	7/19 (37%)
		C2H2 Zn finger	360..380	CDD:275368	7/19 (37%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	8/19 (42%)
		C2H2 Zn finger	444..464	CDD:275368	8/19 (42%)
		C2H2 Zn finger	472..492	CDD:275368	11/19 (58%)
		C2H2 Zn finger	500..520	CDD:275368	8/19 (42%)
		C2H2 Zn finger	528..548	CDD:275368	9/19 (47%)
znf526	NP_001120164.1	C2H2 Zn finger	17..37	CDD:275368
		C2H2 Zn finger	68..88	CDD:275368
		C2H2 Zn finger	108..128	CDD:275368
		C2H2 Zn finger	289..309	CDD:275368
		C2H2 Zn finger	316..336	CDD:275368
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..418	CDD:275368	6/18 (33%)
		C2H2 Zn finger	494..515	CDD:275368	7/20 (35%)
		COG5048	521..853	CDD:227381	144/331 (44%)
		zf-C2H2	521..543	CDD:278523	9/21 (43%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..560	CDD:290200	14/24 (58%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		C2H2 Zn finger	579..599	CDD:275368	10/19 (53%)
		C2H2 Zn finger	607..627	CDD:275368	7/19 (37%)
		C2H2 Zn finger	635..652	CDD:275368	6/16 (38%)
		C2H2 Zn finger	663..682	CDD:275368	7/18 (39%)
		C2H2 Zn finger	691..711	CDD:275368	7/19 (37%)
		C2H2 Zn finger	719..739	CDD:275368	8/19 (42%)
		C2H2 Zn finger	747..767	CDD:275368	8/19 (42%)
		zf-H2C2_2	759..784	CDD:290200	14/24 (58%)
		C2H2 Zn finger	775..795	CDD:275368	11/19 (58%)
		zf-H2C2_2	787..812	CDD:290200	15/24 (63%)
		C2H2 Zn finger	803..823	CDD:275368	8/19 (42%)
		C2H2 Zn finger	831..851	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910