Protein Alignment ALDH18A1 and P5CS

DIOPT Version :10

• Sequence 1: NP_002851.2
• Gene: ALDH18A1 / 5832
• HGNCID: 9722
• Length: 795
• Species: Homo sapiens
• Sequence 2: NP_649375.1
• Gene: P5CS / 40443
• FlyBaseID: FBgn0037146
• Length: 776
• Species: Drosophila melanogaster
• Alignment Length: 796
• Identity: 446/796 - (56%)
• Similarity: 563/796 - (70%)
• Gaps: 36/796 - (4%)

Human     2 LSQVYRCGFQPFNQHLLPWVKCTTVFRSHCIQPSVIRHVRSWSNIPFITVPLSRTHGKSFAHRSE 66
            |:|..|.||     :...|    ..|.||..:..::...|.          |.:.| .:|..||:
  Fly     8 LAQSLRNGF-----YRNAW----RAFSSHGPRQPLVSPERR----------LEKAH-PTFTERSQ 52

Human    67 LKHAKRIVVKLGSAVVTRGDECGLALGRLASIVEQVSVLQNQGREMMLVTSGAVAFGKQRLRHEI 131
            ||:|:|:||||||||:||.|..||||||||||||||:....:|||:|:|||||||||||:|..|:
  Fly    53 LKYARRLVVKLGSAVITREDNHGLALGRLASIVEQVAECHLEGREVMMVTSGAVAFGKQKLAQEL 117

Human   132 LLSQSVRQALHSGQNQLKEMAIPVLEARACAAAGQSGLMALYEAMFTQYSICAAQILVTNLDFHD 196
            |:|.|:|:.|:...:  ||.....||.||.||.||||||:||:|||.||.:..||:|||..||::
  Fly   118 LMSLSMRETLNPKDS--KEFDGATLEPRAAAAVGQSGLMSLYDAMFAQYGVKIAQVLVTKPDFYN 180

Human   197 EQKRRNLNGTLHELLRMNIVPIVNTNDAVVPPA-----EPNSDLQGVNVISVKDNDSLAARLAVE 256
            |:.|.||..||.||:.:|||||:||||||.||.     ||....:  ..|.:||||||:|.||.|
  Fly   181 EETRNNLFCTLSELISLNIVPIINTNDAVSPPMFIRDDEPAGGAR--RGIPIKDNDSLSAMLAAE 243

Human   257 MKTDLLIVLSDVEGLFDSPPGSDDAKLIDIFYPGDQQSVTFGTKSRVGMGGMEAKVKAALWALQG 321
            ::.||||::|||:|:::.||..|.|||:..:...|..|:.||.||:||.|||::|||||.|||..
  Fly   244 VQADLLILMSDVDGIYNKPPWEDGAKLMHTYTSDDSNSIEFGKKSKVGTGGMDSKVKAATWALDR 308

Human   322 GTSVVIANGTHPKVSGHVITDIVEGKKVGTFFSEVKPAGPT--VEQQGEMARSGGRMLATLEPEQ 384
            |.||||.||...|    .|..|:.|:||||||:|...:...  ||...|.||:|.|.:..|.|.|
  Fly   309 GVSVVICNGMQEK----AIKTIIGGRKVGTFFTEATESANAVPVEVMAENARTGSRQMQALTPAQ 369

Human   385 RAEIIHHLADLLTDQRDEILLANKKDLEEAE-GRLAAPLLKRLSLSTSKLNSLAIGLRQIAASSQ 448
            ||..::.|||||..:...||.||.|||.||: ..||.|||.||||:.:||.:|::||:|||..|.
  Fly   370 RASAVNTLADLLVSREKFILDANAKDLAEAQKSGLAKPLLSRLSLNPAKLKNLSVGLKQIAEDSH 434

Human   449 DSVGRVLRRTRIAKNLELEQVTVPIGVLLVIFESRPDCLPQVAALAIASGNGLLLKGGKEAAHSN 513
            .:|||||||||:|..|||:||||||||||||||||||.||||||||:||.|||||||||||||||
  Fly   435 KNVGRVLRRTRLADQLELKQVTVPIGVLLVIFESRPDSLPQVAALAMASANGLLLKGGKEAAHSN 499

Human   514 RILHLLTQEALSIHGVKEAVQLVNTREEVEDLCRLDKMIDLIIPRGSSQLVRDIQKAAKGIPVMG 578
            :.|..|.:|||:..|.:.||.||:||||:.||..::..||||||||||.|||.||:.:..|||:|
  Fly   500 KALMELVKEALATVGAEHAVSLVSTREEISDLLSMENHIDLIIPRGSSDLVRSIQQQSLHIPVLG 564

Human   579 HSEGICHMYVDSEASVDKVTRLVRDSKCEYPAACNALETLLIHRDLLRTPLFDQIIDMLRVEQVK 643
            |:||:||:|:|.:|.::|..|:.||:||:|||||||:||||||.||:...:|..:.:||:.|.||
  Fly   565 HAEGVCHVYIDRDADLEKALRIARDAKCDYPAACNAMETLLIHEDLMSGAIFGDVCNMLKREGVK 629

Human   644 IHAGPKFASYLTFSPSEVKSLRTEYGDLELCIEVVDNVQDAIDHIHKYGSSHTDVIVTEDENTAE 708
            |:|||:....|||.|...|||:.|||.||.|||||.::.:||:|||.||||||||||||::..|.
  Fly   630 IYAGPRLNQQLTFGPPAAKSLKHEYGALECCIEVVPSLDEAINHIHTYGSSHTDVIVTENDAAAR 694

Human   709 FFLQHVDSACVFWNASTRFSDGYRFGLGAEVGISTSRIHARGPVGLEGLLTTKWLLRGKDHVVSD 773
            .||..|||||||.|||:||:||:||||||||||||:|||||||||:||||||||:|.|:||..:|
  Fly   695 QFLGSVDSACVFHNASSRFADGFRFGLGAEVGISTARIHARGPVGVEGLLTTKWILEGQDHAAAD 759

Human   774 FSEHGSLKYLHENLPI 789
            |:|.|...:|||.||:
  Fly   760 FAEGGGRTWLHETLPL 775

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ALDH18A1	NP_002851.2	Glutamate 5-kinase	1..361		179/363 (49%)
		P5CS	64..794	CDD:130164	433/734 (59%)
		Gamma-glutamyl phosphate reductase	362..795		267/431 (62%)
P5CS	NP_649375.1	P5CS	50..775	CDD:130164	432/732 (59%)