Protein Alignment PEX5 and Pex5

DIOPT Version :10

• Sequence 1: XP_011519095.1
• Gene: PEX5 / 5830
• HGNCID: 9719
• Length: 675
• Species: Homo sapiens
• Sequence 2: NP_033021.2
• Gene: Pex5 / 19305
• MGIID: 1098808
• Length: 639
• Species: Mus musculus
• Alignment Length: 656
• Identity: 600/656 - (91%)
• Similarity: 618/656 - (94%)
• Gaps: 19/656 - (2%)

Human    22 MAMRELVEAECGGANPLMKLAGHFTQDKALRQEGLRPGPWPPGAPASEAVSVLEVESPGAASEAA 86
            ||||||||.||||||||||||.||||||||||||||||||||||.|:|.|
Mouse     1 MAMRELVEGECGGANPLMKLATHFTQDKALRQEGLRPGPWPPGASAAETV--------------- 50

Human    87 SKPLGVASEDELVAEFLQDQNAPLVSRAPQTFKMDDLLAEMQQIEQSNFRQAPQRAPGVADLALS 151
            ||||||.:|||||:||||||||.|||||||||||||||||||:||||||||||||||||||||||
Mouse    51 SKPLGVGTEDELVSEFLQDQNATLVSRAPQTFKMDDLLAEMQEIEQSNFRQAPQRAPGVADLALS 115

Human   152 ENWAQEFLAAGDAVDVTQDYNETDWSQEFISEVTDPLSVSPARWAEEYLEQSEEKLWLGEPEGTA 216
            ||||||||||||||||.|||||||||||||:||||||||||||||||||||||||||||:.||::
Mouse   116 ENWAQEFLAAGDAVDVAQDYNETDWSQEFIAEVTDPLSVSPARWAEEYLEQSEEKLWLGDQEGSS 180

Human   217 T-DRWYDEYHPEEDLQHTASDFVAKVDDPKLANSEFLKFVRQIGEGQVSLESGAGSGRAQAEQWA 280
            | |||||||||||||||||||||:||||||||||||||||||||||||||||.||||.|||||||
Mouse   181 TADRWYDEYHPEEDLQHTASDFVSKVDDPKLANSEFLKFVRQIGEGQVSLESAAGSGGAQAEQWA 245

Human   281 AEFIQQQGTSDAWVDQFTRPVN-TSALDMEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPW 344
            ||||||||||:|||||||||.| .:||.:||||||||||||||||||||||||||||||||||||
Mouse   246 AEFIQQQGTSEAWVDQFTRPGNKIAALQVEFERAKSAIESDVDFWDKLQAELEEMAKRDAEAHPW 310

Human   345 LSDYDDLTSATYDKGYQFEEENPLRDHPQPFEEGLRRLQEGDLPNAVLLFEAAVQQDPKHMEAWQ 409
            ||||||||||:||||||||||||||||||||||||.||:||||||||||||||||||||||||||
Mouse   311 LSDYDDLTSASYDKGYQFEEENPLRDHPQPFEEGLHRLEEGDLPNAVLLFEAAVQQDPKHMEAWQ 375

Human   410 YLGTTQAENEQELLAISALRRCLELKPDNQTALMALAVSFTNESLQRQACETLRDWLRYTPAYAH 474
            |||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||:|||||
Mouse   376 YLGTTQAENEQELLAISALRRCLELKPDNRTALMALAVSFTNESLQRQACETLRDWLRYSPAYAH 440

Human   475 LVTPAEEGAGGAGLGPSKRILGSLLSDSLFLEVKELFLAAVRLDPTSIDPDVQCGLGVLFNLSGE 539
            ||.|.||||.||  ||||||||||||||||||||:||||||||||||||||||||||||||||||
Mouse   441 LVAPGEEGATGA--GPSKRILGSLLSDSLFLEVKDLFLAAVRLDPTSIDPDVQCGLGVLFNLSGE 503

Human   540 YDKAVDCFTAALSVRPNDYLLWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCIN 604
            ||||||||||||||||||||:||||||||||||||||||||||||||||||||||||||||||||
Mouse   504 YDKAVDCFTAALSVRPNDYLMWNKLGATLANGNQSEEAVAAYRRALELQPGYIRSRYNLGISCIN 568

Human   605 LGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSTLLT 669
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||.
Mouse   569 LGAHREAVEHFLEALNMQRKSRGPRGEGGAMSENIWSTLRLALSMLGQSDAYGAADARDLSALLA 633

Human   670 MFGLPQ 675
            ||||||
Mouse   634 MFGLPQ 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PEX5	XP_011519095.1	TadD	322..470	CDD:444034	143/147 (97%)
		TPR repeat	375..399	CDD:276809	21/23 (91%)
		TPR repeat	404..434	CDD:276809	29/29 (100%)
		Spy	405..>622	CDD:443119	207/216 (96%)
		TPR repeat	439..467	CDD:276809	26/27 (96%)
		TPR repeat	524..552	CDD:276809	27/27 (100%)
		TPR repeat	557..587	CDD:276809	28/29 (97%)
		TPR repeat	592..619	CDD:276809	26/26 (100%)
Pex5	NP_033021.2	Amphipathic helix 1 (AH1). /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	11..33		20/21 (95%)
		LVxEF motif. /evidence=ECO:0000250|UniProtKB:P50542	62..66		2/3 (67%)
		Amphipathic helix 2 (AH2). /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	81..99		16/17 (94%)
		WxxxF/Y motif 1. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	118..122		3/3 (100%)
		WxxxF/Y motif 2. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	140..144		3/3 (100%)
		WxxxF/Y motif 3. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	159..163		3/3 (100%)
		WxxxF/Y motif 4. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	185..189		3/3 (100%)
		Amphipathic helix 3 (AH3). /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	191..207		14/15 (93%)
		WxxxF/Y motif 5. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	244..248		3/3 (100%)
		WxxxF/Y motif 6. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	258..262		3/3 (100%)
		Amphipathic helix 4 (AH4). /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	286..302		15/15 (100%)
		TadD	288..436	CDD:444034	143/147 (97%)
		WxxxF/Y motif 7. /evidence=ECO:0000250|UniProtKB:A0A1L8FDW4	310..314		3/3 (100%)
		TPR 1	337..370		30/32 (94%)
		TPR repeat	341..365	CDD:276809	21/23 (91%)
		TPR repeat	370..400	CDD:276809	29/29 (100%)
		Spy	371..>586	CDD:443119	207/216 (96%)
		TPR 2	371..404		32/32 (100%)
		TPR 3	405..438		30/32 (94%)
		TPR repeat	405..433	CDD:276809	26/27 (96%)
		TPR 4	452..485		31/34 (91%)
		TPR 5	488..521		32/32 (100%)
		TPR repeat	488..516	CDD:276809	27/27 (100%)
		TPR repeat	521..551	CDD:276809	28/29 (97%)
		TPR 6	522..555		31/32 (97%)
		TPR 7	556..589		32/32 (100%)
		TPR repeat	556..583	CDD:276809	26/26 (100%)