DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PEX2 and Pex2

DIOPT Version :9

Sequence 1:	NP_000309.2	Gene:	PEX2 / 5828	HGNCID:	9717	Length:	305	Species:	Homo sapiens
Sequence 2:	NP_648210.1	Gene:	Pex2 / 38941	FlyBaseID:	FBgn0035876	Length:	281	Species:	Drosophila melanogaster

Alignment Length:	299	Identity:	89/299 - (29%)
Similarity:	148/299 - (49%)	Gaps:	40/299 - (13%)

- Green bases have known domain annotations that are detailed below.

Human    14 VLRISQLDALELNKALEQLVWSQFTQCFHGFKPGLLARFEPEVKACLWVFLWRFTIYSKNATVGQ 78
            |.|::|:||:.|||.:.:|:.....:......|.|..:.:||:...:...:|..::..:.:|.||
  Fly     7 VPRVNQIDAIYLNKDIARLIRDNLLENLQAISPVLFIKIQPELDLIIQSAIWFGSVGKRCSTFGQ 71

Human    79 SVLNIKYKNDFSPNLRYQPPSKNQKIWYAVCTI----GGRWLEERCYDLFRNHHLASFGKVKQCV 139
            .:|.:.|.        .:..:.::.:.:.:.|:    ...|.|.|   |.|.....|     :.:
  Fly    72 QLLVLAYD--------AEKLTVSRLVLHFILTVLPGYVKSWEERR---LTRRVEWFS-----EAI 120

Human   140 NFVIGLLKLGGLINFLIFLQRGKFATLTERLLGIHSVFCKPQNICEVGFEYMNRELLWHGFAEFL 204
            .:|.....:..::|:..||:.|:..||.:.|||:..:..:.....::|::|:.|||||.||.|.|
  Fly   121 MWVENSALILNILNYFRFLKTGRKPTLVDYLLGLDYISLRNNQRRDIGYKYLTRELLWGGFMEIL 185

Human   205 IFLLPLINVQKLKAKLSSWCI----------PLTGAPNSDNTLATSGKECALCGEWPTMPHTIGC 259
            ..:||:||.:||:..|.||..          |...||..  ||:|:   |..|||.||:||.:||
  Fly   186 GLVLPIINFRKLQRVLKSWTFSGRRLEDRDGPAFLAPQM--TLSTT---CTFCGERPTLPHHMGC 245

Human   260 EHIFCYFCAKSSFLFDVYFTCPKCGTEVHSLQPLKSGIE 298
            .||:||:|..::.|.|..|.||.||    |..| :|||:
  Fly   246 GHIYCYYCLNANVLTDASFCCPNCG----SACP-ESGIQ 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PEX2	NP_000309.2	Pex2_Pex12	27..224	CDD:398431	48/200 (24%)
PEX2	NP_000309.2	RING-HC_PEX2	243..284	CDD:319440	20/40 (50%)
Pex2	NP_648210.1	Pex2_Pex12	22..207	CDD:282595	48/200 (24%)
Pex2	NP_648210.1	RING	230..269	CDD:214546	20/38 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158685
Domainoid	1	1.000	69	1.000	Domainoid score	I9678
eggNOG	1	0.900	-	-		E1_KOG2879
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H269
Inparanoid	1	1.050	134	1.000	Inparanoid score	I4600
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53949
OrthoDB	1	1.010	-	-		D1494604at2759
OrthoFinder	1	1.000	-	-		FOG0005881
OrthoInspector	1	1.000	-	-		oto90667
orthoMCL	1	0.900	-	-		OOG6_103635
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5623
SonicParanoid	1	1.000	-	-		X5660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.700