Protein Alignment PWP2 and CG12325

DIOPT Version :10

• Sequence 1: NP_005040.2
• Gene: PWP2 / 5822
• HGNCID: 9711
• Length: 919
• Species: Homo sapiens
• Sequence 2: NP_610618.1
• Gene: CG12325 / 36144
• FlyBaseID: FBgn0033557
• Length: 949
• Species: Drosophila melanogaster
• Alignment Length: 955
• Identity: 445/955 - (46%)
• Similarity: 625/955 - (65%)
• Gaps: 56/955 - (5%)

Human     1 MKFAYRFSNLLGTVYRRGNLNFTCDGNSVISPVGNRVTVFDLKNNKSDTLPLATRYNVKCVGLSP 65
            |||:|:|||||||:||.|||.||.||||||||||||:||:|||||||.||.|.:|||...:.|||
  Fly     1 MKFSYKFSNLLGTIYRNGNLVFTPDGNSVISPVGNRITVYDLKNNKSRTLSLESRYNYTNIALSP 65

Human    66 DGRLAIIVDEGGDALLVSLVCRSVLHHFHFKGSVHSVSFSPDGRKFVVTKGNIAQMYHAPGK-KR 129
            ||.|.|.|:|.|:|.|:|::..:|:|...|:..|..:.|||:|..|.|...|:..::.|||: ..
  Fly    66 DGSLLIAVNEKGEAQLISMMSCTVIHRHKFQTGVQCICFSPNGAFFAVAVQNVVLIFCAPGEITG 130

Human   130 EFNAFVLDKTYFGPYDETTCIDWTDDSRCFVVGSKDMSTWVFGAERWDNLIYYALGGHKDAIVAC 194
            |:|.|||.:.:.|.:|:.|.:||:.|||...:|.:|.||.:.......|...|.|.||.||||||
  Fly   131 EYNPFVLRRRFLGGFDDVTWLDWSSDSRLLAIGCRDSSTKIVAINYTKNFRTYNLSGHTDAIVAC 195

Human   195 FFESNSLDLYSLSQDGVLCMWQCDTPPEGL------RLKPPAGWKADLLQREEEE------EEEE 247
            |||:|||.|.::|::|.||:|:|...|..|      ::.||        ||::|:      |.|:
  Fly   196 FFEANSLHLNTISRNGQLCLWECSLAPSDLEDAERPKIAPP--------QRKKEKKAVSDNESED 252

Human   248 DQEGDRETTIRGKATPAEEEKTGKVK-----------YSRLAKYFF----NKEGDFNNLTAAAFH 297
            |.|...|.....:.:..|.|....:|           |.::.:::.    .||.....||||.::
  Fly   253 DVENVVEKDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLADEPRKEQRDVQLTAANYN 317

Human   298 KKSHLLVTGFASGIFHLHELPEFNLIHSLSISDQSIASVAINSSGDWIAFGCSGLGQLLVWEWQS 362
            .::.:||..|:||.|:|:|||:.|:||||||||..|::...|.:|||:|.....:||||||||||
  Fly   318 TRTKVLVVAFSSGAFYLYELPDVNMIHSLSISDYPISAALFNCTGDWVALASREIGQLLVWEWQS 382

Human   363 ESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKVWNTLSGFCFVTFTEHSSGVTGVTFTATG 427
            |.|::|||||.:.|..:|||.|||:|.|||:|.|||:|||.|.||||||:||:|||||:.|:...
  Fly   383 EQYIMKQQGHSSEMTCIAYSSDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNK 447

Human   428 YVVVTSSMDGTVRAFDLHRYRNFRTFTSPRPTQFSCVAVDASGEIVSAGAQDSFEIFVWSMQTGR 492
            ..:|:||:||||||||::|||||||||||.|.||||||||.|||:|.||.||.|:||:||::||:
  Fly   448 KFLVSSSLDGTVRAFDVNRYRNFRTFTSPNPAQFSCVAVDYSGELVVAGGQDVFDIFLWSVKTGK 512

Human   493 LLDVLSGHEGPISGLCFNPM--KSVLASASWDKTVRLWDMFDSWRTKETLALTSDALAVTFRPDG 555
            ||:::||||||:..:.|:|:  .|.|.|.||||||::|:..:|....||:...||...|||.|.|
  Fly   513 LLEIISGHEGPVVSIAFSPVATSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSPSG 577

Human   556 AELAVATLNSQITFWDPENAVQTGSIEGRHDLKTGRKELDKITAKHAAKGKAFTALCYSADGHSI 620
            .|:|||||:..||.:|.::|.|..:||||:||..||.|.|.|||:..|:...|:.:.|||||..|
  Fly   578 EEIAVATLSGNITIFDIKSAGQVTTIEGRNDLSAGRLETDIITARKNAQANYFSTIEYSADGECI 642

Human   621 LAGGMSKFVCIYHVREQILMKRFEISCNLSLDAMEEFLNRRKMTEFGNLALIDQDAGQEDG-VAI 684
            ||.|.|..:|||||||.||:|:|||:.|.|||.:.:|::|:.::||||:||:::....|.| |||
  Fly   643 LAAGKSANICIYHVREAILLKKFEITQNHSLDGLNDFISRKHLSEFGNMALVEEREELEGGRVAI 707

Human   685 PLPGVRKGDMSSRHFKPEIRVTSLRFSPTGRCWAATTTEGLLIYSLDTRVLFDPFELDTSVTPGR 749
            .||||::||||||.|:.|:||.|::|||||:.:||..||||.||:||..|:||||:|...|||..
  Fly   708 RLPGVQRGDMSSRRFQQEVRVFSVKFSPTGQAFAAAGTEGLCIYALDKGVVFDPFDLSLEVTPKA 772

Human   750 VREALRQQDFTRAILMALRLNESKLVQEALEAVPRGEIEVVTSSLPELYVEKVLEFLASSFEVSR 814
            |.|:|:||::|:|::|:|:|||..|:...||.||..::|:|.:.|...:.:::|:.||...:.:.
  Fly   773 VHESLKQQNYTKALVMSLKLNEPNLIALVLERVPYKDVELVCADLSPEFAQRLLQQLARQLQSTP 837

Human   815 HLEFYLLWTHKLLMLHGQK--LKSRAGTLLPVIQFLQKSIQRHLDDLSKLCSWNHYNMQYALAVS 877
            |:||||.|:..||..||.:  :....|.|.     |.:.:.|..:.|:|:|.:|.|.::..|..:
  Fly   838 HIEFYLQWSCCLLTKHGNQDGVFQHTGLLA-----LHEVLSRKYEMLNKICDYNKYTLKVLLDRA 897

Human   878 KQRGTKRSLDPLGSEEEAE------ASEDDSLHLLGGGGRDSEEE 916
            .:...|....|..:||:::      .|:||.    .|..:.|:||
  Fly   898 DKLEQKNEGKPNATEEDSDEEMLLIRSKDDE----NGQAQFSDEE 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PWP2	NP_005040.2	WD 1	12..50		30/37 (81%)
		YncE	<25..>114	CDD:442618	49/88 (56%)
		WD 2	53..93		18/39 (46%)
		WD 3	94..132		13/38 (34%)
		WD40	96..443	CDD:475233	158/374 (42%)
		WD40 repeat	101..142	CDD:293791	15/41 (37%)
		WD 4	142..181		13/38 (34%)
		WD40 repeat	148..186	CDD:293791	13/37 (35%)
		WD 5	186..225		23/44 (52%)
		WD40 repeat	191..258	CDD:293791	29/78 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..267		9/34 (26%)
		WD 6	286..325		16/38 (42%)
		WD40	291..635	CDD:441893	195/345 (57%)
		WD40 repeat	292..327	CDD:293791	17/34 (50%)
		WD 7	328..368		21/39 (54%)
		WD40 repeat	333..371	CDD:293791	20/37 (54%)
		WD 8	371..410		24/38 (63%)
		WD40 repeat	377..413	CDD:293791	24/35 (69%)
		WD 9	413..452		24/38 (63%)
		WD40 repeat	418..454	CDD:293791	22/35 (63%)
		WD 10	456..498		27/41 (66%)
		WD40 repeat	462..498	CDD:293791	23/35 (66%)
		WD 11	499..538		18/40 (45%)
		WD40 repeat	504..541	CDD:293791	15/38 (39%)
		WD 12	541..580		18/38 (47%)
		WD40 repeat	546..601	CDD:293791	29/54 (54%)
		WD 13	603..642		21/38 (55%)
		WD40 repeat	608..632	CDD:293791	12/23 (52%)
		WD 14	700..740		23/39 (59%)
		Utp12	770..875	CDD:461125	32/106 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	882..919		11/41 (27%)
CG12325	NP_610618.1	WD40	<20..424	CDD:441893	180/411 (44%)
		WD40 repeat	59..94	CDD:293791	15/34 (44%)
		WD40 repeat	99..143	CDD:293791	16/43 (37%)
		WD40 repeat	149..187	CDD:293791	13/37 (35%)
		WD40 repeat	192..247	CDD:293791	24/62 (39%)
		WD40	306..657	CDD:441893	195/350 (56%)
		WD40 repeat	353..391	CDD:293791	20/37 (54%)
		WD40 repeat	397..433	CDD:293791	24/35 (69%)
		WD40 repeat	438..474	CDD:293791	22/35 (63%)
		WD40 repeat	482..518	CDD:293791	23/35 (66%)
		WD40 repeat	524..557	CDD:293791	13/32 (41%)
		WD40 repeat	565..594	CDD:293791	15/28 (54%)
		Utp12	793..895	CDD:461125	32/106 (30%)