Protein Alignment NECTIN2 and si:ch73-22o12.1

DIOPT Version :9

• Sequence 1: NP_001036189.1
• Gene: NECTIN2 / 5819
• HGNCID: 9707
• Length: 538
• Species: Homo sapiens
• Sequence 2: XP_021322530.1
• Gene: si:ch73-22o12.1 / 560816
• ZFINID: ZDB-GENE-110411-27
• Length: 505
• Species: Danio rerio
• Alignment Length: 547
• Identity: 176/547 - (32%)
• Similarity: 263/547 - (48%)
• Gaps: 72/547 - (13%)

Human    17 LLWPLLLLLLLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPG-LYISLVTW--QRPDAPAN 78
            ||..|.||::..:.||.|||:  |||....|.||.|.|..  |.|| ..::.|:|  :|.|  ..
Zfish     6 LLGALFLLIVQGSLAQHVRVE--PEVVSFPGQTVTLRCQF--PNPGDTQLTQVSWIFERTD--TE 64

Human    79 HQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFA 143
            ..|:|.|||..|.::|:..|.|.|::|||        ....|.:.::.:..:.:.|||.|.||:|
Zfish    65 RTNIAVFHPNFGVNYPTTSPVSGRVTFVS--------NPPTLDNPSIQIKDVKMTDEGRYICEYA 121

Human   144 TFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQ 208
            |:|.|:.:|::.|.::|||||.|....|:..:.|..||.|.|..|||.|.|:|.::|:......:
Zfish   122 TYPSGNEQGVSSLVMLAKPKNTATTVTVSAGKTPVIVARCESSNGRPAATITWSTALNGNVTTPK 186

Human   209 VSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWY 273
            .:.....||::.|.:.|.|....:|..::|.|.|.:..:|...|:.|.|.|||.|.|.||::|||
Zfish   187 KTDNPDNTVSIQSVYMLAPQPEDNGKDISCIVSHRTMAQPETFPMKLVVEYPPVVQIKGYNNNWY 251

Human   274 LGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMG 338
            .|:|.|.|:|....||.||...|.|.||..|.:...:.::|.:..||...||||:|.|.|::|.|
Zfish   252 RGQTSAHLTCHADGNPVPTTVTWKTLSGHMPETVQVRENRLAVQQVDDTINTTFICEVKNSLGYG 316

Human   339 RAEQVIFVRE--TPNTAGAGATGGIIGGIIAAIIATAVAATGILIC---RQQRKEQTLQGAEEDE 398
            |.:..:.|||  .||     :..|:|.|:|.|.:...:...|:..|   ..:|::...:|.
Zfish   317 RDQVTVVVREQAPPN-----SNAGVIVGVIFACLLAILLLGGLAYCLVSHNRRQQHGYRGT---- 372

Human   399 DLEGPPSYKPPTPKAKLEAQEMPSQLFTLGASEHSPLKTPYFDAGASCTEQEMPRYHELPTLEER 463
               |.||..|         .:..::||  |:::.|  |....:.|.:.|    |.|.....|.|:
Zfish   373 ---GKPSGTP---------YDSFTRLF--GSAKSS--KNGTGNNGNNNT----PIYRGEVVLNEK 417

Human   464 SG--PLHPGATSLGSPIPVPPGPPAVEDVSLDLE-DE-------EGEEEEEYLDKIN---PIYDA 515
            :.  .:|||..:|......    ...||:.|..| ||       |.|||:|..|..:   ||...
Zfish   418 TANQGMHPGGVALLETTHT----HTAEDILLSREMDEVERKKFDELEEEDERYDHFSGGGPILQL 478

Human   516 LSYSSPSD---SYQGKGFVMSR-AMYV 538
            ..:....|   ..|..|.|:|| |:||
Zfish   479 RPHDDDIDDDMESQRDGSVISRTAVYV 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN2	NP_001036189.1	IG_like	40..158	CDD:214653	41/120 (34%)
		Ig	48..159	CDD:299845	37/113 (33%)
		Ig	162..257	CDD:299845	29/94 (31%)
		IG_like	278..346	CDD:214653	25/67 (37%)
		Ig_3	<280..333	CDD:290638	20/52 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	390..414		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	462..489		5/28 (18%)
si:ch73-22o12.1	XP_021322530.1	Ig1_PVR_like	35..137	CDD:319295	37/113 (33%)
		Ig2_Nectin-2_like	140..235	CDD:319328	29/94 (31%)
		Ig	257..314	CDD:325142	22/56 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332635
Domainoid	1	1.000	56	1.000	Domainoid score	I34808
eggNOG	1	0.900	-	-		E1_28Q44
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I10607
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG42615
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006006
OrthoInspector	1	1.000	-	-		mtm6770
orthoMCL	1	0.900	-	-		OOG6_114522
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X243
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.660