Protein Alignment NECTIN1 and Nectin1

DIOPT Version :9

• Sequence 1: NP_002846.3
• Gene: NECTIN1 / 5818
• HGNCID: 9706
• Length: 517
• Species: Homo sapiens
• Sequence 2: NP_067399.2
• Gene: Nectin1 / 58235
• MGIID: 1926483
• Length: 515
• Species: Mus musculus
• Alignment Length: 517
• Identity: 489/517 - (94%)
• Similarity: 506/517 - (97%)
• Gaps: 2/517 - (0%)

Human     1 MARMGLAGAAGRWWGLALGLTAFFLPGVHSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQV 65
            |||||||||||||||||||||||||||.|:|||||||||||||||||||||||||||||||||||
Mouse     1 MARMGLAGAAGRWWGLALGLTAFFLPGTHTQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQV 65

Human    66 TWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFP 130
            ||||::||||||:|||||:||||||.||.:|||||||||.|||||||.|||||||:|||||||||
Mouse    66 TWQKASNGSKQNMAIYNPTMGVSVLPPYEKRVEFLRPSFIDGTIRLSGLELEDEGMYICEFATFP 130

Human   131 TGNRESQLNLTVMAKPTNWIEGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEY 195
            |||||||||||||||||||||||:|||||:|||||||||||||||||||||.|||||||||||||
Mouse   131 TGNRESQLNLTVMAKPTNWIEGTRAVLRARKGQDDKVLVATCTSANGKPPSAVSWETRLKGEAEY 195

Human   196 QEIRNPNGTVTVISRYRLVPSREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYL 260
            |||||||||||||||||||||||||:||||||||||:|||:||||||||||||||||||||||||
Mouse   196 QEIRNPNGTVTVISRYRLVPSREAHRQSLACIVNYHLDRFRESLTLNVQYEPEVTIEGFDGNWYL 260

Human   261 QRMDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTR 325
            ||.|||||||||||||||||||||||||||||||||||||||:|||.||||||||||||||||||
Mouse   261 QRTDVKLTCKADANPPATEYHWTTLNGSLPKGVEAQNRTLFFRGPITYSLAGTYICEATNPIGTR 325

Human   326 SGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYS 390
            |||||||||||||||: ||||||||.:|||||||||||:||||||||||:|||||||||||||||
Mouse   326 SGQVEVNITEFPYTPT-PEHGRRAGQMPTAIIGGVAGSVLLVLIVVGGIIVALRRRRHTFKGDYS 389

Human   391 TKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGG 455
            |||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||||
Mouse   390 TKKHVYGNGYSKAGIPQHHPPMAQNLQYPDDSDDEKKAGPLGGSSY-EEEEEEEGGGGGERKVGG 453

Human   456 PHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV 517
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   454 PHPKYDEDAKRPYFTVDEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN1	NP_002846.3	Ig1_Nectin-1_like	45..143	CDD:143294	87/97 (90%)
		Ig2_Nectin-1_like	146..243	CDD:143298	90/96 (94%)
		Ig	265..330	CDD:319273	62/64 (97%)
		Interaction with FGFR. /evidence=ECO:0000250	282..299		16/16 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..488		87/88 (99%)
Nectin1	NP_067399.2	Ig1_Nectin-1_like	45..143	CDD:143294	87/97 (90%)
		Ig2_Nectin-1_like	146..243	CDD:143298	90/96 (94%)
		Ig	265..330	CDD:319273	62/64 (97%)
		Interaction with FGFR	282..299		16/16 (100%)
		TM_EGFR-like	353..382	CDD:213052	26/28 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..486		86/87 (99%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83967776
Domainoid	1	1.000	369	1.000	Domainoid score	I12589
eggNOG	1	0.900	-	-		E1_28Q44
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2138
Inparanoid	1	1.050	1012	1.000	Inparanoid score	I5706
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40538
OrthoDB	1	1.010	-	-		D237316at33208
OrthoFinder	1	1.000	-	-		FOG0009281
OrthoInspector	1	1.000	-	-		oto112070
orthoMCL	1	0.900	-	-		OOG6_117425
Panther	1	1.100	-	-	LDO	PTHR23277
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9785
SonicParanoid	1	1.000	-	-		X243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	18	18.300