DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NECTIN1 and nectin1b

DIOPT Version :9

Sequence 1:	NP_002846.3	Gene:	NECTIN1 / 5818	HGNCID:	9706	Length:	517	Species:	Homo sapiens
Sequence 2:	NP_001161041.1	Gene:	nectin1b / 557665	ZFINID:	ZDB-GENE-090224-2	Length:	541	Species:	Danio rerio

Alignment Length:	501	Identity:	283/501 - (56%)
Similarity:	336/501 - (67%)	Gaps:	33/501 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    29 HSQVVQVNDSMYGFIGTDVVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPY 93
            :.|.||.:.|..||:|..|.|.|.|.|..|.|||:||||||..||:||||||.||::|||||.|:
Zfish    62 NGQSVQTDPSKSGFVGDTVELKCLFINGKPPVKISQVTWQKLINGTKQNVAIANPALGVSVLTPF 126

Human    94 RERVEFLRP--------SFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWI 150
            ::||.|..|        |..|.||..|.|.|.||..||||:.|||.||||:.:||||.|:|...:
Zfish   127 KDRVSFKHPAVRQRTPSSLEDTTIVFSSLRLSDEAAYICEYTTFPAGNRENMVNLTVFARPVTKM 191

Human   151 EGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNPNGTVTVISRYRLVP 215
            ..|...:.|:..: .|:.||||.|||||||||:.|:|.|||||.:||.|||||||||.|.|.::|
Zfish   192 TLTSPTIVARTPK-RKMPVATCMSANGKPPSVIKWDTTLKGEATFQETRNPNGTVTVRSNYIVLP 255

Human   216 SREAHQQSLACIVNYHMDRFKESLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPATEY 280
            |||.|:|.|.|||.|..:||.:|:.|||||||||.||||||||||.|.:|:|||.||||||.|.|
Zfish   256 SRETHRQKLTCIVTYRSERFTDSVILNVQYEPEVKIEGFDGNWYLNRPNVQLTCNADANPPVTVY 320

Human   281 HWTTLNGSLPKGVEAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTP----S 341
            .|..||||||..:|.:|.|||||||:.|.|.|||:|||||.||||||.||||:||.|..|    .
Zfish   321 QWKLLNGSLPNNIEIKNNTLFFKGPVTYELGGTYVCEATNSIGTRSGLVEVNVTELPNIPFDERE 385

Human   342 PPEHGRRAGPVPTAIIGGVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSKAGIP 406
            .|.....:|    |.|||..|.:.|::..:..:|..||||:.||||||||||||:||||||||..
Zfish   386 IPAELHSSG----AAIGGAVGGVALLVAAIALLVFFLRRRQRTFKGDYSTKKHVFGNGYSKAGGM 446

Human   407 QHHPPMAQNLQYPDDSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTV 471
            ..||||.:|||||||||||||...:.|..         |...|:|...|    ..||.|||||||
Zfish   447 PAHPPMPKNLQYPDDSDDEKKPAQISGPG---------GFESGDRDFDG----NSEDLKRPYFTV 498

Human   472 DEAEARQDGYGDRTLGYQYDPEQLDLAENMVSQNDGSFISKKEWYV 517
            ||.|:|.  |.:|||.:|||||. ::|::||||.|||.||||||||
Zfish   499 DEGESRD--YDERTLAFQYDPEP-EIADDMVSQTDGSVISKKEWYV 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN1	NP_002846.3	Ig1_Nectin-1_like	45..143	CDD:143294	58/105 (55%)
		Ig2_Nectin-1_like	146..243	CDD:143298	52/96 (54%)
		Ig	265..330	CDD:319273	44/64 (69%)
		Interaction with FGFR. /evidence=ECO:0000250	282..299		9/16 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..488		45/88 (51%)
nectin1b	NP_001161041.1	IG_like	70..183	CDD:214653	61/112 (54%)
		Ig	80..184	CDD:299845	58/103 (56%)
		Ig	187..283	CDD:299845	52/96 (54%)
		IG_like	304..373	CDD:214653	47/68 (69%)
		IGc2	304..363	CDD:197706	38/58 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	189	1.000	Domainoid score	I13730
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I6449
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40538
OrthoDB	1	1.010	-	-		D182700at7742
OrthoFinder	1	1.000	-	-		FOG0009281
OrthoInspector	1	1.000	-	-		otm28170
orthoMCL	1	0.900	-	-		OOG6_117425
Panther	1	1.100	-	-	LDO	PTHR23277
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9785
SonicParanoid	1	1.000	-	-		X243
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	15	15.510