Protein Alignment NECTIN1 and Fas3

DIOPT Version :9

• Sequence 1: NP_002846.3
• Gene: NECTIN1 / 5818
• HGNCID: 9706
• Length: 517
• Species: Homo sapiens
• Sequence 2: NP_001097174.1
• Gene: Fas3 / 35097
• FlyBaseID: FBgn0000636
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 553
• Identity: 114/553 - (20%)
• Similarity: 189/553 - (34%)
• Gaps: 148/553 - (26%)

Human    47 VVLHCSFANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYRERVEFLR---------- 101
            :|..|     |.::....:||.:.  ..:.|.|:.|......:|..|...:.:.|
  Fly     4 IVFIC-----LAAILTDALTWAQV--NVEPNTALLNEGDRTELLCRYGRSINYCRIEIPGEQKVL 61

Human   102 ---------PSFT---------DGTIRLSRLELEDEGVYICEFATFPTGNRES-QLNLTVMAKPT 147
                     |.||         ...:.:.|::..:.|...|....  .|...| .::|.|..:|.
  Fly    62 NLSPEWSKTPGFTYFGAGLTAGQCGVSIERVKASNNGQVKCSLGV--EGEELSGTIDLVVALRPQ 124

Human   148 NWI--------------EGTQAVLRAKKGQDDKVLVATCTSANGKPPSVVSW------ETRLKGE 192
            ..|              |||:  .||:           |:..:|:||:.:||      ..:....
  Fly   125 QPIIELLSRPNREGYFNEGTE--FRAR-----------CSVRDGRPPANISWYIDNMPANKRTTP 176

Human   193 AEYQEIRNPNGTV-TVISRYRLVPSREAHQQSLACIVNYHMDRFKESL-------TLNVQY---- 245
            .|.....|.|..: |.:...:...|.|...:.|.|..::..||  ||:       .:||:|
  Fly   177 LEVMSSTNDNVELSTSVQEIQWHLSPEDSNRKLVCRSHHQTDR--ESVPPQEAAYIINVRYAPVH 239

Human   246 EPEVTIEGFDGNWYLQRMD-VKLTCKADANPPATEYHWTTLNGSL--------------PK--GV 293
            :|:..:.|.    ||:... |.:|.:|...|   :..| |::|::              |:  |.
  Fly   240 QPDAAVYGL----YLEHTAIVNITIRASPQP---KIEW-TIDGAIVGQGRTDGRYSAYEPQYLGN 296

Human   294 EAQNRTLFFKGPINYSLAGTYICEATNPIGTRSGQVEVNITEFPYTPSPPEHGRRAGPVPTAIIG 358
            :..|.||...|.........|...|:|.:|....||.::.:..|.:.|          :..|.|.
  Fly   297 DEYNVTLAIAGLTLEDTTKIYNLRASNELGLTDYQVRISSSSKPPSSS----------LDVAAIV 351

Human   359 GVAGSILLVLIVVGGIVVALRRRRHTFKGDYSTKKHVYGNGYSK---AGIPQHHPPMAQNLQYPD 420
            |:..::.::::||..||.|....|..| |..|.|.........|   .|..|:|......|:.|:
  Fly   352 GIVVAVAVLVLVVLLIVFARATGRWCF-GGKSIKTPTNETQIDKQLELGAQQNHGQNVALLETPN 415

Human   421 DSDDEKKAGPLGGSSYEEEEEEEEGGGGGERKVGGPHPKYDEDAKRPYFTVDEAEARQDGYGDRT 485
            ..       .|.|:|...|......|.|.:.::......:|||....|.|..|:..
  Fly   416 GI-------TLLGASKLREVNGNGNGNGQQDRLSVERRHHDEDDSFEYGTDRESSV--------- 464

Human   486 LGYQYDPEQLDLAENMVSQ----NDGSFISKKE 514
                |:|....|...::||    |..|..|.|:
  Fly   465 ----YNPTTRPLKSILMSQAAGRNSRSSASDKD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NECTIN1	NP_002846.3	Ig1_Nectin-1_like	45..143	CDD:143294	20/124 (16%)
		Ig2_Nectin-1_like	146..243	CDD:143298	25/124 (20%)
		Ig	265..330	CDD:319273	18/80 (23%)
		Interaction with FGFR. /evidence=ECO:0000250	282..299		6/32 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	399..488		18/91 (20%)
Fas3	NP_001097174.1	C2-set_2	141..221	CDD:285423	21/94 (22%)
		Ig_TrkABC_d4	235..>333	CDD:143173	23/105 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149333
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28Q44
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.830