DRSC/TRiP Functional Genomics Resources

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Protein Alignment NECTIN1 and him-4

DIOPT Version :9

Sequence 1:NP_002846.3 Gene:NECTIN1 / 5818 HGNCID:9706 Length:517 Species:Homo sapiens
Sequence 2:NP_001024582.1 Gene:him-4 / 181187 WormBaseID:WBGene00001863 Length:5198 Species:Caenorhabditis elegans


Alignment Length:390 Identity:93/390 - (23%)
Similarity:136/390 - (34%) Gaps:99/390 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    31 QVVQVNDSMYGFIGTDVVLHCS-FANPLPSVKITQVTWQKSTNGSKQNVAIYNPSMGVSVLAPYR 94
            :||..::.|....|....:.|. |.||.|     .|.|.|...                   ||.
 Worm  3128 RVVMASEVMRVVEGRQTTIRCEVFGNPEP-----VVNWLKDGE-------------------PYT 3168

Human    95 ERVEFLRPSFTDGTIRLSRLELEDEGVYICEFATFPTGNRESQLNLTVMAKPTNWIEGTQAVLRA 159
            .  :.|:.|.....:.|....|.|.|.|.| .||...|..::..::.|:..|.  ||..:.||:.
 Worm  3169 S--DLLQFSTKLSYLHLRETTLADGGTYTC-IATNKAGESQTTTDVEVLVPPR--IEDEERVLQG 3228

Human   160 KKGQDDKVLVATCTSANGKPPSVVSWETRLKGEAEYQEIRNP-----NGTVTVISRYRLVPSREA 219
            |:|   ...:..| ...|:|...|:|:...|...::    ||     |.|.....:|..:.|.||
 Worm  3229 KEG---NTYMVHC-QVTGRPVPYVTWKRNGKEIEQF----NPVLHIRNATRADEGKYSCIASNEA 3285

Human   220 HQQSLACIVNYHMDRFKE------SLTLNVQYEPEVTIEGFDGNWYLQRMDVKLTCKADANPPAT 278
            .    ..:.::.:|.|.:      ..|.|:       :||         ...|:.||.|.:|..|
 Worm  3286 G----TAVADFLIDVFTKPTFETHETTFNI-------VEG---------ESAKIECKIDGHPKPT 3330

Human   279 EYHWTTLNGSLPKGVEAQNRTLFFKGPINYSL------AGTYICEATNPIGTRSGQVEVNITEFP 337
             ..|  |.|..|..::  |..|..:|.....|      .|.|.|.|||..|......:||:...|
 Worm  3331 -ISW--LKGGRPFNMD--NIILSPRGDTLMILKAQRFDGGLYTCVATNSYGDSEQDFKVNVYTKP 3390

Human   338 YTPSPPEHGRRAGPVPTAIIGGVAGSILLVLIVVGG--IVVALRR--------RRHTFKGDYSTK 392
            |.....:.      .|.|:.|   |.|:|...|:|.  ..|..:|        .|||...:|..|
 Worm  3391 YIDETIDQ------TPKAVAG---GEIILKCPVLGNPTPTVTWKRGDDAVPNDSRHTIVNNYDLK 3446

Human   393  392
             Worm  3447  3446

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NECTIN1NP_002846.3 Ig1_Nectin-1_like 45..143 CDD:143294 21/98 (21%)
Ig2_Nectin-1_like 146..243 CDD:143298 24/107 (22%)
Ig 265..330 CDD:319273 21/70 (30%)
Interaction with FGFR. /evidence=ECO:0000250 282..299 5/16 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..488
him-4NP_001024582.1 IG_like 442..515 CDD:214653
IG 527..605 CDD:214652
Ig 628..694 CDD:319273
I-set 702..789 CDD:369462
I-set 793..881 CDD:369462
Ig 899..974 CDD:386229
I-set 1012..1081 CDD:369462
Ig 1109..1172 CDD:319273
Ig 1196..1263 CDD:319273
IG_like 1277..1358 CDD:214653
I-set 1373..1450 CDD:369462
Ig 1474..1544 CDD:386229
IGc2 1563..1628 CDD:197706
Ig 1651..1732 CDD:386229
Ig 1755..1818 CDD:319273
Ig 1839..1912 CDD:386229
Ig 1930..2002 CDD:386229
IG_like 2014..2095 CDD:214653
Ig 2094..2182 CDD:386229
Ig 2190..2283 CDD:386229
I-set 2296..2380 CDD:369462
Ig 2384..2471 CDD:386229
IGc2 2492..2556 CDD:197706
Ig 2580..2654 CDD:386229
Ig 2686..2753 CDD:319273
IG_like 2768..2850 CDD:214653
I-set 2854..2939 CDD:369462
IG_like 2951..3031 CDD:214653
I-set 3046..3116 CDD:369462
I-set 3127..3213 CDD:369462 25/111 (23%)
Ig 3217..3292 CDD:386229 21/88 (24%)
I-set 3300..3386 CDD:369462 26/106 (25%)
I-set 3396..3472 CDD:369462 15/60 (25%)
I-set 3481..3569 CDD:369462
I-set 3591..3663 CDD:369462
Ig 3667..3762 CDD:386229
Ig 3775..3848 CDD:386229
Ig 3859..3947 CDD:386229
IGc2 3968..4031 CDD:197706
Ig_3 4045..4119 CDD:372822
Ig_3 4136..4210 CDD:372822
Ig <4262..4314 CDD:386229
Ig 4318..4406 CDD:386229
IG_like 4418..4496 CDD:214653
I-set 4570..4654 CDD:369462
I-set 4752..4836 CDD:369462
EGF_CA 4996..5027 CDD:238011
EGF_CA 5034..5076 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23277
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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