DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PVR and si:ch73-22o12.1

DIOPT Version :9

Sequence 1:	NP_006496.4	Gene:	PVR / 5817	HGNCID:	9705	Length:	417	Species:	Homo sapiens
Sequence 2:	XP_021322530.1	Gene:	si:ch73-22o12.1 / 560816	ZFINID:	ZDB-GENE-110411-27	Length:	505	Species:	Danio rerio

Alignment Length:	405	Identity:	139/405 - (34%)
Similarity:	208/405 - (51%)	Gaps:	37/405 - (9%)

- Green bases have known domain annotations that are detailed below.

Human    31 VQAPTQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTW---ARHGESGSMAVFHQTQGPSYSE---- 88
            |:...:|..|.|.:|||.|  |.||...|.::|::|   ....|..::||||...|.:|..
Zfish    23 VRVEPEVVSFPGQTVTLRC--QFPNPGDTQLTQVSWIFERTDTERTNIAVFHPNFGVNYPTTSPV 85

Human    89 SKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRSVDIWLRVLAKPQNTAEVQK 153
            |.|:.||:.  ...|.|.|:::..:::.|||.|.|.:.|:|.|:......|.:||||:|||....
Zfish    86 SGRVTFVSN--PPTLDNPSIQIKDVKMTDEGRYICEYATYPSGNEQGVSSLVMLAKPKNTATTVT 148

Human   154 VQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGTVTVTSLWILVPSSQVDGKN 218
            |.....||.:|||.|:.|||.|.|||.:.|.|...|.:.......||::.|:::|.|..:.:||:
Zfish   149 VSAGKTPVIVARCESSNGRPAATITWSTALNGNVTTPKKTDNPDNTVSIQSVYMLAPQPEDNGKD 213

Human   219 VTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATLTCDARSNPEPTGYNWSTTM 283
            ::|.|.|.:..:|:...:.|.|.|||.|.|.||:||||.||..|.|||.|..||.||...|.|..
Zfish   214 ISCIVSHRTMAQPETFPMKLVVEYPPVVQIKGYNNNWYRGQTSAHLTCHADGNPVPTTVTWKTLS 278

Human   284 GPLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQVKE-GPPSEHSGMSRNAIIF 347
            |.:|.....:..:|.::.||..||||.||.|.|:||..:.::||.|:| .||:.::|:    |:.
Zfish   279 GHMPETVQVRENRLAVQQVDDTINTTFICEVKNSLGYGRDQVTVVVREQAPPNSNAGV----IVG 339

Human   348 LVLGILVFLILLGIGIYFYWSKCSREVLWHCHL---CPSSTEH---------ASASANGHVSYSA 400
            ::...|:.::|||...|...|...|:  .|.:.   .||.|.:         |.:|.||
Zfish   340 VIFACLLAILLLGGLAYCLVSHNRRQ--QHGYRGTGKPSGTPYDSFTRLFGSAKSSKNG------ 396

Human   401 VSRENSSSQDPQTEG 415
             :..|.::..|...|
Zfish   397 -TGNNGNNNTPIYRG 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PVR	NP_006496.4	Ig1_PVR_like	43..142	CDD:319295	33/105 (31%)
		Ig2_Nectin-2_like	145..240	CDD:319328	33/94 (35%)
		DYNLT1 binding	368..372		1/3 (33%)
		ITIM motif	396..401		0/4 (0%)
si:ch73-22o12.1	XP_021322530.1	Ig1_PVR_like	35..137	CDD:319295	33/105 (31%)
		Ig2_Nectin-2_like	140..235	CDD:319328	33/94 (35%)
		Ig	257..314	CDD:325142	24/56 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194332633
Domainoid	1	1.000	56	1.000	Domainoid score	I34808
eggNOG	1	0.900	-	-		E1_28Q44
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	230	1.000	Inparanoid score	I10607
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006006
OrthoInspector	1	1.000	-	-		mtm6770
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23277
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X243
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850