Protein Alignment PVR and nectin2

DIOPT Version :9

• Sequence 1: NP_006496.4
• Gene: PVR / 5817
• HGNCID: 9705
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001004860.1
• Gene: nectin2 / 448156
• XenbaseID: XB-GENE-947429
• Length: 464
• Species: Xenopus tropicalis
• Alignment Length: 473
• Identity: 145/473 - (30%)
• Similarity: 227/473 - (47%)
• Gaps: 90/473 - (19%)

Human    13 LVALLVLSWPPPGTGDVVVQAP-----TQVPGFLGDSVTLPCYLQVPNMEVTHVSQLTWARHGES 72
            |.::|:|..|       |:||.     .:|.|.||..:||||......::: .|:|:.|.:  :|
 Frog     4 LCSVLLLLCP-------VLQAQEINVNEKVTGTLGQQITLPCTFNNNGVDM-QVTQIMWMK--DS 58

Human    73 GSMAVFHQTQGPSYS---ESKRLEFVAARLGAELRNASLRMFGLRVEDEGNYTCLFVTFPQGSRS 134
            .::|    |..|.:.   ::|. :|   .|.|...:|:|.:..||..|||||.|...|||.|:|.
 Frog    59 TNLA----TYSPQFGIHVQNKN-DF---NLTASPSSATLLIKLLRASDEGNYICEVTTFPGGNRR 115

Human   135 VDIWLRVLAKPQNTAEVQKVQLTGEPVPMARCVSTGGRPPAQITWHSDLGGMPNTSQVPGFLSGT 199
            ...:|.|.|:|:|:||...|......||:|:|.|..||||:||||.|.|.|..:|: :.....||
 Frog   116 GITYLSVKAEPRNSAEALPVIAGDIEVPVAKCASANGRPPSQITWRSTLPGNFDTT-MNNNTDGT 179

Human   200 VTVTSLWILVPSSQVDGKNVTCKVEHESFEKPQLLTVNLTVYYPPEVSISGYDNNWYLGQNEATL 264
            .||.|.:.|||:...|.:.|.|.:.::|  |..::.:.|::.|.|.|:|.||||||||.:..|:|
 Frog   180 YTVVSNYKLVPTWTADKQEVICIISYDS--KESVIPITLSIQYSPIVTIEGYDNNWYLKRLGASL 242

Human   265 TCDARSNPEPTGYNWSTTMG-PLPPFAVAQGAQLLIRPVDKPINTTLICNVTNALGARQAELTVQ 328
            ||:|..||:||.|.|.|..| |||....|:...|.:..||:.:|||::|.||||||:|.::..|.
 Frog   243 TCNAHGNPQPTVYTWKTADGSPLPNTVKAKDNVLYVDEVDERVNTTIVCEVTNALGSRASQQEVL 307

Human   329 VKEGPPSEHS--------GMSRNAIIFLVLGILVFLILLGIGIY-------------FYWSKCSR 372
            |:|......:        |:....::.|:|..::|:::...|::             |...|.|:
 Frog   308 VRERALENQTNNAGAIAGGVIGGVLVLLLLAAVIFILIRRGGVHKKERGSYNPKPRIFGSGKPSQ 372

Human   373 EVLWH-----------------CHLCPSSTEHASASANGHVSYSAVSRENSSSQ----------- 409
            |..:.                 ..|.||..|.....:...:.|:.:..::...:
 Frog   373 EFTYQDDSEMGKPLKASGPLRDSGLSPSLAEEEEDESEERMKYNVLEDDDEEEKFNEVGPMLQLR 437

Human   410 ---DP--------QTEGT 416
               ||        ||:|:
 Frog   438 PHHDPYLDDDMESQTDGS 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVR	NP_006496.4	Ig1_PVR_like	43..142	CDD:319295	31/101 (31%)
		Ig2_Nectin-2_like	145..240	CDD:319328	36/94 (38%)
		DYNLT1 binding	368..372		1/3 (33%)
		ITIM motif	396..401		1/4 (25%)
nectin2	NP_001004860.1	Ig	32..123	CDD:325142	31/101 (31%)
		Ig2_Nectin-2_like	126..218	CDD:319328	36/94 (38%)
		Ig	<241..308	CDD:325142	31/66 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X243
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000