Protein Alignment PVR and Fas3

DIOPT Version :9

• Sequence 1: NP_006496.4
• Gene: PVR / 5817
• HGNCID: 9705
• Length: 417
• Species: Homo sapiens
• Sequence 2: NP_001097174.1
• Gene: Fas3 / 35097
• FlyBaseID: FBgn0000636
• Length: 577
• Species: Drosophila melanogaster
• Alignment Length: 381
• Identity: 84/381 - (22%)
• Similarity: 137/381 - (35%)
• Gaps: 116/381 - (30%)

Human    64 LTWA---------------------RHGES---------GSMAVFHQTQGPSYSESKRLEFVAAR 98
            ||||                     |:|.|         |...|.:.:  |.:|::....:..|.
  Fly    17 LTWAQVNVEPNTALLNEGDRTELLCRYGRSINYCRIEIPGEQKVLNLS--PEWSKTPGFTYFGAG 79

Human    99 LGAELRNASLRMFGLRVEDEGNYTC-LFVTFPQGSRSVDIWLRVLAKPQNTAEVQKVQLTGEPVP 162
            |.|.....|:..  ::..:.|...| |.|...:.|.::|  |.|..:||...    ::|...|..
  Fly    80 LTAGQCGVSIER--VKASNNGQVKCSLGVEGEELSGTID--LVVALRPQQPI----IELLSRPNR 136

Human   163 ----------MARCVSTGGRPPAQITWHSDLGGMP-NTSQVP-GFLSGTVTVTSL--------WI 207
                      .|||....|||||.|:|:.|  .|| |....| ..:|.|.....|        |.
  Fly   137 EGYFNEGTEFRARCSVRDGRPPANISWYID--NMPANKRTTPLEVMSSTNDNVELSTSVQEIQWH 199

Human   208 LVPSSQVDGKNVTCKVEHESFEK---PQ----LLTVNLTVYYPPEVSISGYDNNWYLGQNEATLT 265
            |.|..  ..:.:.|:..|::..:   ||    ::.|.....:.|:.::.|.    || ::.|.:.
  Fly   200 LSPED--SNRKLVCRSHHQTDRESVPPQEAAYIINVRYAPVHQPDAAVYGL----YL-EHTAIVN 257

Human   266 CDARSNPEPTGYNWSTTMGPLPPFAVAQG-------------------------AQLLIRPVDKP 305
            ...|::|:|. ..| |..|.:    |.||                         |.|.:.
  Fly   258 ITIRASPQPK-IEW-TIDGAI----VGQGRTDGRYSAYEPQYLGNDEYNVTLAIAGLTLE----- 311

Human   306 INTTLICNV--TNALGARQAELTVQVKEGPPSEHSGMSRNAIIFLVLGILVFLILL 359
             :||.|.|:  :|.||....::.:.....|||....::....|.:.:.:||.::||
  Fly   312 -DTTKIYNLRASNELGLTDYQVRISSSSKPPSSSLDVAAIVGIVVAVAVLVLVVLL 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PVR	NP_006496.4	Ig1_PVR_like	43..142	CDD:319295	22/108 (20%)
		Ig2_Nectin-2_like	145..240	CDD:319328	30/121 (25%)
		DYNLT1 binding	368..372
		ITIM motif	396..401
Fas3	NP_001097174.1	C2-set_2	141..221	CDD:285423	23/83 (28%)
		Ig_TrkABC_d4	235..>333	CDD:143173	23/114 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28Q44
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740