Protein Alignment PTBP2 and heph

DIOPT Version :10

• Sequence 1: NP_001287916.1
• Gene: PTBP2 / 58155
• HGNCID: 17662
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_001247399.1
• Gene: heph / 48571
• FlyBaseID: FBgn0011224
• Length: 898
• Species: Drosophila melanogaster
• Alignment Length: 609
• Identity: 301/609 - (49%)
• Similarity: 382/609 - (62%)
• Gaps: 100/609 - (16%)

Human    17 KKYVTVNN--RGSDELLSGSVLSSPNSNMSSMVVTANGND---SKKFKGE--DKMDGA---PSRV 71
            ::|:...|  ||||||||.:.:.:|.|:        |.|.   :||.|.|  ..:.|.   .|:|
  Fly   313 EQYIYKLNYLRGSDELLSQAAVMAPASD--------NNNQDLATKKAKLEPGTVLAGGIAKASKV 369

Human    72 LHIRKLPGEVTETEVIALGLPFGKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQP 136
            :|:|.:|.|..|.:|||||:|||:|||:|:||||||||:|:|.|.:|.:||:.|:...|.:|.:.
  Fly   370 IHLRNIPNESGEADVIALGIPFGRVTNVLVLKGKNQAFIEMADEISATSMVSCYTVTPPQMRGRM 434

Human   137 IYIQYSNHKELKTD---------------------------------NTLN-----QRAQAVLQA 163
            :|:|:|||:|||||                                 |..|     ..|..:||.
  Fly   435 VYVQFSNHRELKTDQGHNNSTAHSDYSVQSPASGSPLPLSAAANATSNNANSSSDSNSAMGILQN 499

Human   164 VTAVQT-ANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIITFTKN 227
            .:||.. .||..:|          ..:.|||:|::::.|||:||:|||||.::|.||||:|||||
  Fly   500 TSAVNAGGNTNAAG----------GPNTVLRVIVESLMYPVSLDILHQIFQRYGKVLKIVTFTKN 554

Human   228 NQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNNDKSRDYTRPDLPSGD 292
            |.||||:||.|..:||.||..||||||||.|||||||.|||..||||||||||||:|.|.||  .
  Fly   555 NSFQALIQYPDANSAQHAKSLLDGQNIYNGCCTLRIDNSKLTALNVKYNNDKSRDFTNPALP--P 617

Human   293 GQPALD--PA------------IAAAFAKETSLLGLPVAAVPGALSPL--------------AIP 329
            |:|.:|  |.            |||......|:.||   ..||.|.|.              |:|
  Fly   618 GEPGVDIMPTAGGLMNTNDLLLIAARQRPSLSVNGL---GAPGVLPPFALGLGTPLTGGYNNALP 679

Human   330 NAAAAAAAAAAGRVGMPGVSAGGNTVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSA 394
            |.||.:.|.:...........|.:.||||||||||||||.:||||||||||||||||||||||||
  Fly   680 NLAAFSLANSGALQTTAPAMRGYSNVLLVSNLNEEMVTPDALFTLFGVYGDVQRVKILYNKKDSA 744

Human   395 LIQMADGNQSQLAMNHLNGQKMYGKIIRVTLSKHQTVQLPREGLDDQGLTKDFGNSPLHRFKKPG 459
            |||||:..|:.|||:||:..:::||.|||..||||.||||:||..|.|||:|:..:|||||||||
  Fly   745 LIQMAEPQQAYLAMSHLDKLRLWGKPIRVMASKHQAVQLPKEGQPDAGLTRDYSQNPLHRFKKPG 809

Human   460 SKNFQNIFPPSATLHLSNIPPSVAEEDLRTLFANTGGTVKAFKFFQRDHKMALLQMATVEEAIQA 524
            |||:|||:||||||||||||.|.:|:|::..|.:....|||||||.:|.||||||:.:||||:.|
  Fly   810 SKNYQNIYPPSATLHLSNIPSSCSEDDIKEAFTSNSFEVKAFKFFPKDRKMALLQLLSVEEAVLA 874

Human   525 LIDLHNYNLGENHHLRVSFSKSTI 548
            ||.:||:.|.|::|||||||||.|
  Fly   875 LIKMHNHQLSESNHLRVSFSKSNI 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTBP2	NP_001287916.1	hnRNP-L_PTB	68..548	CDD:273733	281/546 (51%)
heph	NP_001247399.1	hnRNP-L_PTB	366..898	CDD:273733	281/546 (51%)