Protein Alignment PTBP2 and sm

DIOPT Version :10

• Sequence 1: NP_001287916.1
• Gene: PTBP2 / 58155
• HGNCID: 17662
• Length: 548
• Species: Homo sapiens
• Sequence 2: NP_001246428.1
• Gene: sm / 37254
• FlyBaseID: FBgn0003435
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 521
• Identity: 129/521 - (24%)
• Similarity: 203/521 - (38%)
• Gaps: 128/521 - (24%)

Human    94 GKVTNILMLKGKNQAFLELATEEAAITMVNYYSAVTPHLRNQPIYIQYSNHKELKTDNTLNQRAQ 158
            |....|::.:|.....:....::.....|:.::..||....|...:..||      |:...:|.:
  Fly    17 GGGATIVVTEGPQNKKIRTGVQQPGENDVHMHARSTPQQNQQQALMNKSN------DDLRRKRPE 75

Human   159 AVLQAVTAVQTANTPLSGTTVSESAVTPAQSPVLRIIIDNMYYPVTLDVLHQIFSKFGAVLKIIT 223
                                      |...:.:|...|.|.:||:|:||||:|....|.||:|:.
  Fly    76 --------------------------TTRPNHILLFTIINPFYPITVDVLHKICHPHGQVLRIVI 114

Human   224 FTKNNQFQALLQYGDPVNAQQAKLALDGQNIYNACCTLRIDFSKLVNLNVKYNN--DKSRDYTRP 286
            |.||. .||::::.:...|.:|:..|:|.:||..||||:||::|...||| |.|  |.|.|||..
  Fly   115 FKKNG-VQAMVEFDNLDAATRARENLNGADIYAGCCTLKIDYAKPEKLNV-YKNEPDTSWDYTLS 177

Human   287 DLPS-GDGQPAL--DPAIAAAFA------------------------------------------ 306
            .:.. |:|:..|  :|...|..:
  Fly   178 TVKEIGNGRSPLLQEPLYVATLSTPQQHVSHQHHHHLRQQQQQQHQQQAPQQQPHPQHLHHQQQL 242

Human   307 ------------KETSLLGLPVAAVPGALSP---LAIPNAAAAAAAAAAGRVGMP-GVSAGGN-- 353
                        ||..||| |.||.|...:|   ...|.....||....|.:..| ||..|.|
  Fly   243 VAPAQSHNLYQFKEPPLLG-PGAAFPPFGAPEYHTTTPENWKGAAIHPTGLMKEPAGVVPGRNAP 306

Human   354 -----------TVLLVSNLNEEMVTPQSLFTLFGVYGDVQRVKILYNKKDSALIQMADGNQSQLA 407
                       .|::|..|:.:......||.|..:||:|.|:|.|..|:.:|::||.|....:..
  Fly   307 VAFTPQGQAQGAVMMVYGLDHDTSNTDKLFNLVCLYGNVARIKFLKTKEGTAMVQMGDAVAVERC 371

Human   408 MNHLNGQKM-YGKIIRVTLSKHQTVQ-------LPREGLDDQGLTKDFGNSPLHRFKKPGSKNFQ 464
            :.|||...: .|..|::..||...:.       ||    |.....|::..|..:||..|...:..
  Fly   372 VQHLNNIPVGTGGKIQIAFSKQNFLSEVINPFLLP----DHSPSFKEYTGSKNNRFLSPAQASKN 432

Human   465 NIFPPSATLHLSNIPPSVAEEDLRTLFAN----TGGTVKAFKFFQRDHKMALLQMATVEEAIQAL 525
            .|.|||..||..|.||.:.|:.|..:| |    ...:|:.|..........|::.:.:.:|:.|:
  Fly   433 RIQPPSKILHFFNTPPGLTEDQLIGIF-NIKDVPATSVRLFPLKTERSSSGLIEFSNISQAVLAI 496

Human   526 I 526
            :
  Fly   497 M 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTBP2	NP_001287916.1	hnRNP-L_PTB	68..548	CDD:273733	129/521 (25%)
sm	NP_001246428.1	hnRNP-L_PTB	45..522	CDD:273733	126/493 (26%)