Protein Alignment PURA and Pur-alpha

DIOPT Version :10

• Sequence 1: NP_005850.1
• Gene: PURA / 5813
• HGNCID: 9701
• Length: 322
• Species: Homo sapiens
• Sequence 2: NP_524624.1
• Gene: Pur-alpha / 43797
• FlyBaseID: FBgn0022361
• Length: 275
• Species: Drosophila melanogaster
• Alignment Length: 266
• Identity: 126/266 - (47%)
• Similarity: 168/266 - (63%)
• Gaps: 22/266 - (8%)

Human    26 SGSGSGGGGGGGG--------GGGGSGGGGGGAPGGLQHETQELASKRVDIQNKRFYLDVKQNAK 82
            |..|||..|..|.        |..........|.||...| ||||:|.:.||:||||||||||.:
  Fly     2 SDLGSGDDGISGSKYNVANMEGSSSRNDFDSSAKGGSGVE-QELATKMLQIQSKRFYLDVKQNRR 65

Human    83 GRFLKIAEVGAGGNKSRLTLSMSVAVEFRDYLGDFIEHYAQLGPSQPPDLAQAQDEPRRALKSEF 147
            |||:|:||:||.|.:|::.|::|.|.||||:|..|.::||.|||....:|.:     ...||||.
  Fly    66 GRFIKVAEIGADGRRSQIYLALSTAAEFRDHLSSFSDYYASLGPPNTDNLPE-----DGKLKSEM 125

Human   148 LVRENRKYYMDLKENQRGRFLRIRQTVNRGPGLGSTQGQTIALPAQGLIEFRDALAKLIDDYGVE 212
            ::::.|:||:|||||.||||||:.||:.|    |..:.| |||||||:|||||||..|::::|..
  Fly   126 MIKDYRRYYLDLKENARGRFLRVSQTITR----GGPRSQ-IALPAQGMIEFRDALTDLLEEFGAN 185

Human   213 EE---PAELPEGTSLTVDNKRFFFDVGSNKYGVFMRVSEVKPTYRNSITVPYKVWAKFGHTFCKY 274
            :.   ..:|||...:.||||.|:||:|.|..||:||:||||..:|.|||:|.|.|.:|...|..|
  Fly   186 DGGRFKGDLPEERHMKVDNKNFYFDIGQNNRGVYMRISEVKNNFRTSITIPEKCWIRFRDIFNDY 250

Human   275 SEEMKK 280
            .|:|||
  Fly   251 CEKMKK 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PURA	NP_005850.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		10/36 (28%)
		PurA	58..278	CDD:282672	112/222 (50%)
		PUR repeat I. /evidence=ECO:0000305|PubMed:20976240	60..125		37/64 (58%)
		PUR repeat II. /evidence=ECO:0000305|PubMed:20976240	142..213		39/70 (56%)
		PUR repeat III. /evidence=ECO:0000305|PubMed:20976240	215..281		34/66 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..322
Pur-alpha	NP_524624.1	PurA	41..254	CDD:282672	113/223 (51%)