DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fgfr3 and btl

DIOPT Version :9

Sequence 1:	XP_021336328.1	Gene:	fgfr3 / 58129	ZFINID:	ZDB-GENE-000816-1	Length:	821	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	306/817 - (37%)
Similarity:	425/817 - (52%)	Gaps:	129/817 - (15%)

- Green bases have known domain annotations that are detailed below.

Zfish    66 VGDTVVLSCTPQDFLL--PIVWQKDGDAVSSSNR------------------TRVGQ-KALRIIN 109
            :||.|.:.|..:|..|  .|.|...|:|.:..:.                  ||:.: :.||:.|
  Fly   254 LGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGN 318

Zfish   110 VSYEDSGVYSCRHAHK--SMLLSNY----------TVKV---------IDSLSSGDDEDYDEDED 153
            |..||.|.|.|...::  ..:.::|          ||:.         |.:.|:|:|.|.|.:..
  Fly   319 VLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENP 383

Zfish   154 EA-GNGNAEAPYWTRS-DRMEKKLLAVPAANTVKFRCPAAGNPTPSIHWLKNGKEFKGEQRMGGI 216
            .| .:|....|.:.:. .|::..|    :.|||...||..|.  .:|.|.|:.|....|.   |:
  Fly   384 AAEASGGVGPPVFRKELKRLQHSL----SGNTVNLACPVYGK--ANITWTKDKKPLNREL---GV 439

Zfish   217 KLRDQQWSLVMESAVPSDRGNYTCVVQNKYGTIKHTYQLDVLERSPHRPILQAGLPANQTVVVGS 281
            .:: :.|:|....|...|.|.|.|.|.|.:|.|:..:.:.:.:|:...||:.  :|.||||.|..
  Fly   440 YVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIV--VPQNQTVKVNG 501

Zfish   282 DVEFHCKVYSDAQPHIQWLKHIEVNGSQYGPNGAPYVNVLKTAGIN----TTDKELEILYLTNVS 342
            .:...|.||||..|.:.|.:.:..|.|..|         ||:..|.    |...:..:|.|.||:
  Fly   502 SLVMKCTVYSDLHPTVSWKRVVLKNASLDG---------LKSVEIQNLNFTVTNDSVVLTLRNVT 557

Zfish   343 FEDAGQYTCLAGNSIGYNHHSAWLTV---LPAVEMEREDDYADI--------LIYVTSCVLFILT 396
            |:..|.|||||.:.:|.::.|.:|.|   ||.:|:     ||.:        |..:|...||:|.
  Fly   558 FDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEI-----YALLHAHPLGFTLAAITIVALFLLG 617

Zfish   397 MVIIILCRMWINTQKTLPAPPVQKLSKFPLKRQVTVSL-------ESNSSMNS---NTPLVRIAR 451
            ...|......:..:|.|      || :.....|.|..:       |..|..:|   ..|::||.:
  Fly   618 SAFITFMLRRLRREKLL------KL-RIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEK 675

Zfish   452 -----LSSSDGPMLP--NVSELELPSDPKWEFTRTKLTLGKPLGEGCFGQVVMAEAIGIDKEKPN 509
                 .::..|...|  ..:|.|.|.|..||..|.:|:||..||||.||:||||||.|:.:....
  Fly   676 QRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQL 740

Zfish   510 KPLTVAVKMLKDDGTDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLRE 574
            ....|||||:|::.||.|::.||.|||:|||||||.|||||||.|:|.|||:|:||||..|||::
  Fly   741 AETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKD 805

Zfish   575 YLRARRPPGMD-------YSFDTCKIPNETLTFKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 632
            :|:..||....       |..|...|..:.|..|:|...|:|:|||||||||::|||||||||||
  Fly   806 FLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNV 870

Zfish   633 LVTEDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSYGVLLWEIF 697
            ||::..||||||||||||:.:.:||:|.||||||:||||||:|.::.|..||||||||||||||.
  Fly   871 LVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIM 935

Zfish   698 TLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPTFRQLVEDHDRVL 761
            |.|..|||.| ..|||:..|..|.||:|||.|:..:|::||:|||.....||||.:|||..|.:|
  Fly   936 TYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000

Zfish   762 SMTST---DEYLDLSVPFEQYSPTCPDSNSTCSSGDD 795
            ...|:   |.|||||:|..:..|         ||||:
  Fly  1001 QQASSNPNDAYLDLSMPMLETPP---------SSGDE 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fgfr3	XP_021336328.1	IGc2	67..121	CDD:197706	20/74 (27%)
		Ig2_FGFR	173..257	CDD:143265	24/83 (29%)
		Ig3_FGFR-2	280..369	CDD:143266	29/95 (31%)
		PTKc_FGFR3	468..801	CDD:173652	183/339 (54%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	21/81 (26%)
		Ig	258..340	CDD:143165	19/81 (23%)
		I-set	394..479	CDD:254352	26/94 (28%)
		IGc2	408..469	CDD:197706	21/66 (32%)
		IG_like	492..583	CDD:214653	34/99 (34%)
		Ig	507..583	CDD:299845	28/84 (33%)
		PKc_like	700..1000	CDD:304357	169/299 (57%)
		TyrKc	712..996	CDD:197581	163/283 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760