DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRZ1 and Lar

DIOPT Version :9

Sequence 1:NP_002842.2 Gene:PTPRZ1 / 5803 HGNCID:9685 Length:2315 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:2373 Identity:533/2373 - (22%)
Similarity:876/2373 - (36%) Gaps:689/2373 - (29%)


- Green bases have known domain annotations that are detailed below.


Human   135 MSSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGTEENLDFKAIIDG 199
            :|:|.:....||.|.|             :.|....:|.|     :.:.|||....:..|||   
  Fly   121 VSADATLTIYEGDKTP-------------AGFPVITQGPG-----TRVIEVGHTVLMTCKAI--- 164

Human   200 VESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFKDTVSISESQLAVFC 264
                   |           |..||      ||              ||..:..|.:|..:.::  
  Fly   165 -------G-----------NPTPN------IY--------------WIKNQTKVDMSNPRYSL-- 189

Human   265 EVLTMQQSGYVMLMDYLQNNFREQQYKFSRQVFSSYTGKEEIHEAVCSSEPENVQADPENYTSLL 329
                  :.|::.    ::|:..|.|.|:.                 |.:| .::..:....|:|.
  Fly   190 ------KDGFLQ----IENSREEDQGKYE-----------------CVAE-NSMGTEHSKATNLY 226

Human   330 V-------TWER-PRVVYDTMIEKFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVL 386
            |       |:.| |..:.:.|:.....|.....|... .|.....|.:||..  .|.:|....||
  Fly   227 VKVRRVPPTFSRPPETISEVMLGSNLNLSCIAVGSPM-PHVKWMKGSEDLTP--ENEMPIGRNVL 288

Human   387 QI-----------VAICTNGLYGKYSDQLIVDMPTDNPELDLFPELIGTEEIIKEEEEG-KDIEE 439
            |:           :|..|.|.....|...:..:||...::.: .|:..|...::...:| :|::.
  Fly   289 QLINIQESANYTCIAASTLGQIDSVSVVKVQSLPTAPTDVQI-SEVTATSVRLEWSYKGPEDLQY 352

Human   440 GAIVNPGRDSATNQIRKKEPQISTTTHYNRIGTKYNE------AKTN--RSPTRGSEFSGKGDVP 496
            ..|....:::  ||...:...|.|..:..|..:.|.|      |..|  |.|.........||..
  Fly   353 YVIQYKPKNA--NQAFSEISGIITMYYVVRALSPYTEYEFYVIAVNNIGRGPPSAPATCTTGDFS 415

Human   497 --NTSLNSTSQPVTKLATEKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAES 559
              .|.:.|..:.|    ..:.:|.::..:|..||.|..|..........|....|  ..|..::.
  Fly   416 FGGTKMESAPRNV----QVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQP--EASWNSQM 474

Human   560 LNTVSITEYEEESLLTSFKLDTGAEDSSGSSP--------ATSAIP-----FISENISQGYI--- 608
            ::...:|...|.:....:.:...|..|.|:.|        |...:|     |.:.:|.:..:   
  Fly   475 VDNSELTTVSELTPHAIYTVRVQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQ 539

Human   609 -----FSSENPETITYDVLIPESARNASEDSTSSGSEESLKD---PSMEGNVWFPSSTDITAQPD 665
                 .||||  .:.|::...::..|.:.....|.||....|   |.....:|      :.|:..
  Fly   540 WTKPTHSSEN--IVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIW------LAARSQ 596

Human   666 VGSGRESFLQTNYTEIRVDESEKTTKSFSAGPVMSQGPSVTDLEMP---------HYSTFAYFPT 721
            .|.|    ..|....:|..:.....::.:|....|...|::.|..|         :|..|     
  Fly   597 RGEG----ATTPPIPVRTKQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVF----- 652

Human   722 EVTPHAFTPSSRQQDLVSTVNVVYSQTTQPVYNGETPLQPSYSSEVF--------PLVTPLLL-- 776
                  |....|:.|..:|:.:  :.|:  :...|......|...|.        |...|::|  
  Fly   653 ------FVEVGREDDEATTMTL--NMTS--IVLDELKRWTEYKIWVLAGTSVGDGPRSHPIILRT 707

Human   777 ------DNQILNTTPAASSSDSALHATPVFPSVDVSFESILSSYD-GAPLLPFSSASFSSELFRH 834
                  |.|.:..||..|:|   :|.: ..|.::.....|:..|. .|..|......|.:|.|:.
  Fly   708 QEDVPGDPQDVKATPLNSTS---IHVS-WKPPLEKDRNGIIRGYHIHAQELRDEGKGFLNEPFKF 768

Human   835 ------LHTVSQILP------QVTSAT---ESDK-----------VPLHASL--------PVAGG 865
                  ...|:.:.|      ||.:.|   :.|:           ||:..::        |:...
  Fly   769 DVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMEREPIVSI 833

Human   866 DLLLEPSLAQYSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDAMMHARSSGPEPSYAL 930
            :|..|.....|.::      ....|.:|.:...|.:.::                 |||:.:...
  Fly   834 ELEWERPAQTYGEL------RGYRLRWGVKDQALKEEML-----------------SGPQMTKKR 875

Human   931 SDN--EGSQHIFTVSYSSAIPV-HDSVGV--TYQGSLFSGPSHIPIPKSSLITPTASLLQPTHAL 990
            .||  .|.::.|.|:.|:.|.: .::|.:  |.:|:....||:|.|                   
  Fly   876 FDNLERGVEYEFRVAGSNHIGIGQETVKIFQTPEGTPGGPPSNITI------------------- 921

Human   991 SGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGDDNKALSKSEIIYGNETELQ 1055
                         .|..||              |...|:........|..:::.::.:..:.:..
  Fly   922 -------------RFQTPD--------------VLCVTWDPPTREHRNGIITRYDVQFHKKIDHG 959

Human  1056 IPSFNEMVYPSESTVMPNMYDN---VNKLNASLQETSVSISSTKGMFPGSLAHTTTKVFDHEISQ 1117
            :.|...|..  ...|..|:.:|   :.::.|..::.:       |.|...|...|    :.::.:
  Fly   960 LGSERNMTL--RKAVFTNLEENTEYIFRVRAYTKQGA-------GPFSDKLIVET----ERDMGR 1011

Human  1118 VPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSDPASSEMLSPSTQLLFYETSASFSTEVLL 1182
            .|   .|:|...| |:.:.:...:||.|           ..::|.   ..:||..:|        
  Fly  1012 AP---MSLQAEAT-SEQTAEIWWEPVTS-----------RGKLLG---YKIFYTMTA-------- 1050

Human  1183 QPSFQASDVDT-LLKTVLPAVPSDPILVETPKVDKISSTMLHLIVSNSASSENMLHSTSVPVF-- 1244
                 ..|:|. ..|||.....:|  ||...|..:.:       |:.:|..:|.|...|..|.  
  Fly  1051 -----VEDLDDWQTKTVGLTESAD--LVNLEKFAQYA-------VAIAARFKNGLGRLSEKVTVR 1101

Human  1245 ----DVSPTSHMHSASLQGLTISYASE-KYEPVLLKSE-------------SSHQVVP------- 1284
                ||......|..|...:|:|::.. :..||..|..             |..|:||       
  Fly  1102 IKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILK 1166

Human  1285 ---SLYSNDEL--FQTANLEIN------QAHPPKGRHVFATPVLSIDEPL-NTLINKLIHSDEIL 1337
               ..::.:||  |.|.|:.::      ...||  ..:..|..::..:|: ......:::.:|||
  Fly  1167 HYVKTHTINELSPFTTYNVNVSAIPSDYSYRPP--TKITVTTQMAAPQPMVKPDFYGVVNGEEIL 1229

Human  1338 ------TSTKSSVTGKVFAGIPTVAS------DTFVSTDHSVPIGNGHVAITAVSPHR-DGSVTS 1389
                  :.....::......:|...|      |.|: ||..:|..|        .|.| :....:
  Fly  1230 VILPQASEEYGPISHYYLVVVPEDKSNLHKIPDQFL-TDDLLPGRN--------KPERPNAPYIA 1285

Human  1390 TKLLFPSKATSELSHSAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEK 1454
            .|  ||.::.....|        :|.|:|                    .|...:....||.:.:
  Fly  1286 AK--FPQRSIPFTFH--------LGSGDD--------------------YHNFTNRKLEREKRYR 1320

Human  1455 VMNDS--DTHENSLMDQNNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHND 1517
            :...:  ||.:..|. .::|.|..||.:..|                ..||:.|        |. 
  Fly  1321 IFVRAVVDTPQKHLY-TSSPFSEFLSLDMRE----------------APPGERP--------HR- 1359

Human  1518 GKEENDIQTGSALLPLSPESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGIL 1582
                             |:                                              
  Fly  1360 -----------------PD---------------------------------------------- 1361

Human  1583 AAGDSEITPGFPQSPTSSV--TSENSEVFHVSEAEASNSSHESRIGLAEGLESEKKAVIPLVIVS 1645
                    |.:|..|..||  ..:..|:..|                          |:||::.:
  Fly  1362 --------PNWPAEPEVSVNRNKDEPEILWV--------------------------VLPLMVST 1392

Human  1646 ALTFICLVVLVGILIYWRKC---------------------------------FQTAHFYLEDST 1677
            .:....|:||..:....:.|                                 |||         
  Fly  1393 FIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQT--------- 1448

Human  1678 SPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFETLKEFYQEVQSCTVDLGI 1740
             |.:||.||            |||..|..|:..|.::..  |::|:|:::...|          .
  Fly  1449 -PGMISHPP------------IPISEFANHIERLKSNDNQKFSQEYESIEPGQQ----------F 1490

Human  1741 TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLK 1805
            |.|:||...||.||||.|:.|||||||:|..:....|  :|||||||.|||.:..||:|.||||:
  Fly  1491 TWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG--SDYINANYCDGYRKHNAYVATQGPLQ 1553

Human  1806 STAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNF 1870
            .|..|||||.||.....|||:|.|.|:.|.|||||||..|:|.||...||....|.||.|::|.|
  Fly  1554 ETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTF 1618

Human  1871 TLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSA 1935
            .|        .::|....|.:.|..:|.|||.|||::..|.|.|:|:.........|||:|||||
  Fly  1619 QL--------CRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSA 1675

Human  1936 GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000
            ||||||.|||:||||::::||..::|:|.:..:|:||||:||||:||:||||.::|||:...|||
  Fly  1676 GVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV 1740

Human  2001 LDSHIHAYVNALLIPGPAGKT--KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERS 2063
            ...::|.::..|||..| |:|  .:|.:|:.||...:..|.:..|...||:.|||...|:|.|.|
  Fly  1741 PARNLHTHLQKLLITEP-GETISGMEVEFKKLSNVKMDSSKFVTANLPCNKHKNRLVHILPYESS 1804

Human  2064 RVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM 2127
            ||.::.:.| ||:||:|||:|.||...:.:|..|.|:....:|||||:|:||:.:|||:...:.|
  Fly  1805 RVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVMLTKLKEM 1869

Human  2128 AEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKW 2191
            ..:: |.|||: :..:..:.:.|..:||     .|..:..:::|.:...:|.....||.||...|
  Fly  1870 GREKCFQYWPH-ERSVRYQYYVVDPIAE-----YNMPQYKLREFKVTDARDGSSRTVRQFQFIDW 1928

Human  2192 PNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVY 2252
            |....|.|..  .:.|..:  .:|...:|||:.||...|...:|.|..|:.::.:::.|..:||:
  Fly  1929 PEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRSGVFITLSIVLERMQYEGVLDVF 1993

Human  2253 QVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285
            |..:::...||.:....:||.|.|:..|..:.:
  Fly  1994 QTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRZ1NP_002842.2 PARM 1089..>1255 CDD:293666 34/172 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1123..1160 7/36 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1397..1523 19/127 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1572 0/28 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1621 7/38 (18%)
PTPc 1716..1991 CDD:214550 130/276 (47%)
PTPc 1752..1991 CDD:238006 120/238 (50%)
Substrate binding. /evidence=ECO:0000250 1933..1939 5/5 (100%)
PTPc 2022..2280 CDD:214550 82/263 (31%)
PTPc 2050..2280 CDD:238006 74/235 (31%)
alpha_CARP_receptor_like 45..298 CDD:239396 30/162 (19%)
fn3 313..401 CDD:278470 22/106 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..462 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650 6/24 (25%)
MFMR 684..>763 CDD:285072 13/87 (15%)
LarNP_001260594.1 Ig 35..129 CDD:299845 2/7 (29%)
I-set 36..129 CDD:254352 2/7 (29%)
IG_like 146..227 CDD:214653 26/156 (17%)
Ig 159..228 CDD:299845 22/139 (16%)
I-set 234..318 CDD:254352 19/86 (22%)
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216 15/70 (21%)
fn3 324..404 CDD:278470 16/82 (20%)
FN3 423..514 CDD:238020 17/96 (18%)
FN3 520..610 CDD:238020 19/101 (19%)
FN3 616..707 CDD:238020 18/105 (17%)
FN3 712..810 CDD:238020 21/101 (21%)
FN3 832..907 CDD:238020 17/97 (18%)
FN3 914..1005 CDD:238020 19/145 (13%)
FN3 1012..1101 CDD:238020 27/128 (21%)
fn3 1106..1198 CDD:278470 18/91 (20%)
PTPc 1476..1731 CDD:214550 130/274 (47%)
PTPc 1503..1731 CDD:238006 120/237 (51%)
PTPc 1763..2022 CDD:214550 82/264 (31%)
PTPc 1791..2022 CDD:238006 74/236 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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