DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRZ1 and Ptp10D

DIOPT Version :9

Sequence 1:NP_002842.2 Gene:PTPRZ1 / 5803 HGNCID:9685 Length:2315 Species:Homo sapiens
Sequence 2:NP_996413.2 Gene:Ptp10D / 32115 FlyBaseID:FBgn0004370 Length:1990 Species:Drosophila melanogaster


Alignment Length:2156 Identity:457/2156 - (21%)
Similarity:725/2156 - (33%) Gaps:743/2156 - (34%)


- Green bases have known domain annotations that are detailed below.


Human   186 GTEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNSTDKYYIYNGSLTSPPCTDTVDWIVFK 250
            |....||:.......|..:....:...|.......||.:...:::|..:.|..      ||:.:.
  Fly    58 GASYRLDYSPPFGYPEPNTTIASREIGDEIQFSRALPGTKYNFWLYYTNFTHH------DWLTWT 116

Human   251 DTVSISE--------------------------SQLAVFCEVLTMQQ--SGYVMLMDYLQNNFRE 287
            .|::.:.                          |..|...:||.:.:  |.|........|.|:.
  Fly   117 VTITTAPDPPSNLSVQVRSGKNAIILWSPPTQGSYTAFKIKVLGLSEASSSYNRTFQVNDNTFQH 181

Human   288 QQYK------FSRQVFSSYTGKEEIHEAVCSSEPENVQADP----------ENYTSLLVTWERPR 336
            ...:      :..|.::.|.|||.:     :....|....|          .|.|:|||.|:.|.
  Fly   182 SVKELTPGATYQVQAYTIYDGKESV-----AYTSRNFTTKPNTPGKFIVWFRNETTLLVLWQPPY 241

Human   337 VV-----YDTMIE----KFAVLYQQLDGEDQTKHEFLTDGYQDLGAILNNLLPNMSYVLQIVAIC 392
            ..     |...||    ..:|||.:.:||.....:          |....|:|..:|.:.:..:.
  Fly   242 PAGIYTHYKVSIEPPDANDSVLYVEKEGEPPGPAQ----------AAFKGLVPGRAYNISVQTMS 296

Human   393 TNGLYGKYSDQLIVDMPTDNPELDLFP-------ELIGTEEIIKEEEEGKDIEEGAIVNPGRDSA 450
                    .|::.:........:.|.|       :.|.:.......|..|.|.|           
  Fly   297 --------EDEISLPTTAQYRTVPLRPLNVTFDRDFITSNSFRVLWEAPKGISE----------- 342

Human   451 TNQIRKKEPQISTTTHYNRIGTKYNEAKTNRSPTRGSEF---SGKGDVPNTSLNSTSQPVTKLAT 512
               ..|.:..::||...:.: .:.||      |....:|   :..|...|..:.:.|..||....
  Fly   343 ---FDKYQVSVATTRRQSTV-PRSNE------PVAFFDFRDIAEPGKTFNVIVKTVSGKVTSWPA 397

Human   513 EKDISLTSQTVTELPPHTVEGTSASLNDGSKTVLRSPHMNLSGTAESLNTVSIT------EYEEE 571
            ..|::|....|..|         .|:||                 :..||:.||      ..::|
  Fly   398 TGDVTLRPLPVRNL---------RSIND-----------------DKTNTMIITWEADPASTQDE 436

Human   572 SLLTSFKLDTGAEDSSGSSPATSAIPFISENISQGYIFS---------SENPETITYDVLIPESA 627
            ..:...:|:|...|:  |:..|....|..|::..|..:|         .|:.||..:.|..|   
  Fly   437 YRIVYHELETFNGDT--STLTTDRTRFTLESLLPGRNYSLSVQAVSKKMESNETSIFVVTRP--- 496

Human   628 RNASEDSTSSGSEESLKDPSMEGNVWFPSSTDITAQPDVGSGRESF-----------LQTNYTEI 681
                    ||...|.||...|..|:.:.|        ||.|.:|.:           |:|..|: 
  Fly   497 --------SSPIIEDLKSIRMGLNISWKS--------DVNSKQEQYEVLYSRNGTSDLRTQKTK- 544

Human   682 RVDESEKTTKSFSAGPVMSQGPSVTDLEMPHYSTFAYFPTEVTPHAFTPSSRQQDLVSTVNVVYS 746
               ||....|:...|         ...|:..::......:|  |||                   
  Fly   545 ---ESRLVIKNLQPG---------AGYELKVFAVSHDLRSE--PHA------------------- 576

Human   747 QTTQPVYNGETPLQPSYSSEVFPLVTPLLLDNQILNTTPAASSSDSAL-HATPVFPSVDVSFESI 810
                            |...|:|        |...|.|.....|:|.| |.:|. .|.:.:..||
  Fly   577 ----------------YFQAVYP--------NPPRNMTIETVRSNSVLVHWSPP-ESGEFTEYSI 616

Human   811 LSSYDGAPLLPFSSASFSSELFRHLHTVSQILPQVTSATESDKVPLHASLPVAGGDLLLEPSLAQ 875
            ....|            |.:.:..|.:|......:|..|:.:|..:..:                
  Fly   617 RYRTD------------SEQQWVRLPSVRSTEADITDMTKGEKYTIQVN---------------- 653

Human   876 YSDVLSTTHAASETLEFGSESGVLYKTLMFSQVEPPSSDA----MMHARS---SGPEP-----SY 928
                         |:.||.||.|..:.   :...||:..:    ::.:|:   ..|:|     ||
  Fly   654 -------------TVSFGVESPVPQEV---NTTVPPNPVSNIIQLVDSRNITLEWPKPEGRVESY 702

Human   929 AL----SDNEGSQHIFTVSYSSAIPVHDSV---------GVTYQGSLFSGPSHIPIPKSSLITPT 980
            .|    |||.|......||.:.:.....:|         ||.|:..:.:....|....:||...|
  Fly   703 ILKWWPSDNPGRVQTKNVSENKSADDLSTVRVLIGELMPGVQYKFDIQTTSYGILSGITSLYPRT 767

Human   981 ASLLQPTHALSGDGEWSGASSDSEFLLPDTDGLTALNISSPVSVAEFTYTTSVFGD----DNKAL 1041
            ..|:|....::     :|...|      :.|.:|.....:|.|.::|.......||    |.:.|
  Fly   768 MPLIQSDVVVA-----NGEKED------ERDTITLSYTPTPQSSSKFDIYRFSLGDAEIRDKEKL 821

Human  1042 SKSEIIYGNETELQIPSFNEMVYPSESTVMPNMYDNVNKLNASLQETSVSISSTKGMFPGSLAHT 1106
            :       |:|:.:: :|..:|        |....|:.....|....|:.|.....::|..:...
  Fly   822 A-------NDTDRKV-TFTGLV--------PGRLYNITVWTVSGGVASLPIQRQDRLYPEPITQL 870

Human  1107 -TTKVFDHEIS---QVPENNFSVQPTHTVSQASGDTSLKPVLSANSEPASSD------------- 1154
             .|.:.|.|||   .:|:..::   ...::..:.|..|...::..:|...||             
  Fly   871 HATNITDTEISLRWDLPKGEYN---DFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVV 932

Human  1155 --PASSEMLSPSTQLLFYETSASFSTEVLLQPSFQASDVDTLLKTVLPAVPSDPILVETPKVDKI 1217
              ...|.:|..|:.|     ||||:|.                    .|||.        :|::.
  Fly   933 RSGTESSVLRSSSPL-----SASFTTN--------------------EAVPG--------RVERF 964

Human  1218 SSTMLHLIVSNSASSENMLHSTSVPVFDVSPTSHMHSASLQGLTISYASEKYEPVLLKSESSHQV 1282
            ..|                        ||.|:......||                         
  Fly   965 HPT------------------------DVQPSEINFEWSL------------------------- 980

Human  1283 VPSLYSNDEL--FQTANLEINQAHPPKGRHVFATPVLSIDEPLNTLINKLIHSDEILTSTKSSVT 1345
             ||..:|..:  |..|...||.                                  ||.      
  Fly   981 -PSSEANGVIRQFSIAYTNINN----------------------------------LTD------ 1004

Human  1346 GKVFAGIPTVASDTFVSTDHSVPIGNGHV----AITAV--SPHRDGSVTSTKLLFPSKATSELSH 1404
                ||:....|:.......::..|..:|    |.||:  .|.|:...|...|..|..||     
  Fly  1005 ----AGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPAT----- 1060

Human  1405 SAKSDAGLVGGGEDGDTDDDGDDDDDDRGSDGLSIHKCMSCSSYRESQEKVMNDSDTHENSLMDQ 1469
                                                :.:....||.|....:.   ..:|...||
  Fly  1061 ------------------------------------QVVPTEVYRSSSTIQIR---FRKNYFSDQ 1086

Human  1470 NNPISYSLSENSEEDNRVTSVSSDSQTGMDRSPGKSPSANGLSQKHNDGKEENDIQTGSALLPLS 1534
            |..:.......:|:|                    :.:|:||..     ....|:|:.|..||..
  Fly  1087 NGQVRMYTIIVAEDD--------------------AKNASGLEM-----PSWLDVQSYSVWLPYQ 1126

Human  1535 PESKAWAVLTSDEESGSGQGTSDSLNENETSTDFSFADTNEKDADGILAAGDSEITPGFPQSPTS 1599
            .....:..                  ||.:..||:....|         ..:.:|  |:...|..
  Fly  1127 AIDPYYPF------------------ENRSVEDFTIGTEN---------CDNHKI--GYCNGPLK 1162

Human  1600 SVTSENSEVFHVSEAEA-SNSSHESRIGLAEGLESEKKAV-IPLVIVSALTFICLVVLVGILIYW 1662
            |.|:...:|...:.|:. :::::...|...:...|...|: :||.|:       ||:||.:|.|.
  Fly  1163 SGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDNTSLIVAITVPLTII-------LVLLVTLLFYK 1220

Human  1663 RK---CFQTAHFYLEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASSG--FTEEFE 1722
            |:   |.:|.    :||.:...:|.|.:.|    :....|.||:|.:|...:.|.|.  |:||||
  Fly  1221 RRRNNCRKTT----KDSRANDNMSLPDSVI----EQNRPILIKNFAEHYRLMSADSDFRFSEEFE 1277

Human  1723 TLKEFYQEVQSCT-VDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINAN 1786
            .||...:: |.|| .||         |.|:.|||:.||:.|||||.||..:.:.:|  :||||||
  Fly  1278 ELKHVGRD-QPCTFADL---------PCNRPKNRFTNILPYDHSRFKLQPVDDDEG--SDYINAN 1330

Human  1787 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEE-YG 1850
            ||.|:|.|:.:|..||||.||.:|||||.||.|...|||:|...||||.|||||||.|.... ||
  Fly  1331 YVPGHNSPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCDQYWPNDTVPVFYG 1395

Human  1851 NFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV 1915
            :.     .||:|......::.:....:.:||::     |::..:|:|.|||.|||.....::.||
  Fly  1396 DI-----KVQILNDSHYADWVMTEFMLCRGSEQ-----RILRHFHFTTWPDFGVPNPPQTLVRFV 1450

Human  1916 RKAAYAKRHAVG----PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLV 1976
            |    |.|..:|    |:||||||||||:||:|.||.:||||.....|:|||.:..:|.:|.::|
  Fly  1451 R----AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKERVWMV 1511

Human  1977 QTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPAGKTKLE-----KQFQL------- 2029
            |||:||:.||..|:..:..||.               |.|||.:....     :|.||       
  Fly  1512 QTEQQYICIHQCLLAVLEGKEN---------------IVGPAREMHDNEGYEGQQVQLDENGDVV 1561

Human  2030 ------LSQSNIQQS------DYSAALKQCNREKNRTSSIIPVERSRVG----------ISSLSG 2072
                  ||..::||:      |.:||:...:::        |:..|..|          :||..|
  Fly  1562 ATIEGHLSHHDLQQAEAEAIDDENAAILHDDQQ--------PLTSSFTGHHTHMPPTTSMSSFGG 1618

Human  2073 EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPN 2137
            .|..:.|    :........::.|.              |:|..:|:::.|             |
  Fly  1619 GGGGHTN----VDAPDRXHSVVNQS--------------DNNNSVVIVLVD-------------N 1652

Human  2138 KDEPINCESFK 2148
            |...:.|:..|
  Fly  1653 KPSSMICKDSK 1663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRZ1NP_002842.2 PARM 1089..>1255 CDD:293666 31/184 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1123..1160 6/51 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1397..1523 14/125 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1543..1572 4/28 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1584..1621 7/37 (19%)
PTPc 1716..1991 CDD:214550 126/282 (45%)
PTPc 1752..1991 CDD:238006 112/243 (46%)
Substrate binding. /evidence=ECO:0000250 1933..1939 5/5 (100%)
PTPc 2022..2280 CDD:214550 27/161 (17%)
PTPc 2050..2280 CDD:238006 17/109 (16%)
alpha_CARP_receptor_like 45..298 CDD:239396 21/145 (14%)
fn3 313..401 CDD:278470 21/106 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 442..462 1/19 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 477..507 5/32 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 628..650 6/21 (29%)
MFMR 684..>763 CDD:285072 9/78 (12%)
Ptp10DNP_996413.2 fn3 124..205 CDD:278470 12/80 (15%)
fn3 220..304 CDD:278470 20/101 (20%)
fn3 315..391 CDD:278470 16/96 (17%)
FN3 405..494 CDD:238020 22/116 (19%)
FN3 511..574 CDD:238020 15/85 (18%)
FN3 583..671 CDD:238020 25/140 (18%)
fn3 683..753 CDD:278470 16/69 (23%)
fn3 787..850 CDD:278470 16/78 (21%)
fn3 866..935 CDD:278470 11/71 (15%)
fn3 961..1043 CDD:278470 24/175 (14%)
PTPc 1272..1525 CDD:214550 125/278 (45%)
PTPc 1298..1525 CDD:238006 111/242 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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