DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment psen2 and Psn

DIOPT Version :9

Sequence 1:	NP_571589.2	Gene:	psen2 / 58026	ZFINID:	ZDB-GENE-000330-9	Length:	441	Species:	Danio rerio
Sequence 2:	NP_001262111.1	Gene:	Psn / 40260	FlyBaseID:	FBgn0284421	Length:	541	Species:	Drosophila melanogaster

Alignment Length:	536	Identity:	251/536 - (46%)
Similarity:	326/536 - (60%)	Gaps:	109/536 - (20%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 SEEDSYN-----------ERSALVQSESPTVPSYNQDN----AMSLPQDTDSKRSGAVRSR-SAS 54
            :.||..|           ||....|.:.....|.|||.    .:::|.....:..|:..|| :..
  Fly    15 ASEDDANVGSQIGAAERLERPPRRQQQRNNYGSSNQDQPDAAILAVPNVVMREPCGSRPSRLTGG 79

Zfish    55 GSGDAGPVDRERADTPDGEEEELTLKYGAKHVIMLFIPVTLCMVVVVATIKSVSFYTEKSGQRLI 119
            |.|..||...|.       |||..|||||:|||.||:||:|||:||||||.|:||| ..:...|:
  Fly    80 GGGSGGPPTNEM-------EEEQGLKYGAQHVIKLFVPVSLCMLVVVATINSISFY-NSTDVYLL 136

Zfish   120 YTPFEEDPNSVGQRLLNSVLNTLVMISVIVFMTIILVLLYKYRCYKFIHGWLILSSLMLLFWFSF 184
            ||||.|.......:..:::.|:|:::||:|.||.:|::|||.|||:.|||||||||.||||.|::
  Fly   137 YTPFHEQSPEPSVKFWSALANSLILMSVVVVMTFLLIVLYKKRCYRIIHGWLILSSFMLLFIFTY 201

Zfish   185 MYLGEVFKTYNVAMDYPTLVMIIWNFGVVGMICIHWKGPLRLQQAYLIVISALMALIFIKYLPEW 249
            :||.|:.:.||:.|||||.::|:||||||||:.|||:|||||||.|||.::|||||:||||||||
  Fly   202 LYLEELLRAYNIPMDYPTALLIMWNFGVVGMMSIHWQGPLRLQQGYLIFVAALMALVFIKYLPEW 266

Zfish   250 SAWVILGAISIYDLIAVLCPKGPLRMLVETAQERNEPIFPALIYSSAMVWMV------------- 301
            :||.:|.||||:||||||.|:||||:||||||||||.|||||||||.:|:.:
  Fly   267 TAWAVLAAISIWDLIAVLSPRGPLRILVETAQERNEQIFPALIYSSTVVYALVNTVTPQQSQATA 331

Zfish   302 --GMADSN-------------NPDSA---GER---------RRSGGGVRTQEGV----------- 328
              ..:.||             :|::|   |:|         :|..|.|...||:
  Fly   332 SSSPSSSNSTTTTRATQNSLASPEAAAASGQRTGNSHPRQNQRDDGSVLATEGMPLVTFKSNLRG 396

Zfish   329 ----------------------ESEDDAPQAGRRQYSAE-----------EDLEEDRGVKLGLGD 360
                                  :.|..:.|:|..|.|.|           .|.:|:||:||||||
  Fly   397 NAEAAGFTQEWSANLSERVARRQIEVQSTQSGNAQRSNEYRTVTAPDQNHPDGQEERGIKLGLGD 461

Zfish   361 FIFYSVLVGKAAATGGDWNTTLACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFSTDN 425
            |||||||||||::. |||.||:|||||||||||||||||||::||||||||||||||:|.|:|..
  Fly   462 FIFYSVLVGKASSY-GDWTTTIACFVAILIGLCLTLLLLAIWRKALPALPISITFGLIFCFATSA 525

Zfish   426 LVRPFMDSLAAHQYYI 441
            :|:|||:.|:|.|.:|
  Fly   526 VVKPFMEDLSAKQVFI 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
psen2	NP_571589.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..74		19/83 (23%)
		Presenilin	80..431	CDD:279427	222/434 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..346		15/93 (16%)
		PAL	407..409		1/1 (100%)
Psn	NP_001262111.1	Presenilin	98..531	CDD:279427	222/434 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588190
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2736
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H386
Inparanoid	1	1.050	431	1.000	Inparanoid score	I1692
OMA	1	1.010	-	-		QHG54370
OrthoDB	1	1.010	-	-		D357270at33208
OrthoFinder	1	1.000	-	-		FOG0002393
OrthoInspector	1	1.000	-	-		otm24389
orthoMCL	1	0.900	-	-		OOG6_101989
Panther	1	1.100	-	-	LDO	PTHR10202
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2736
SonicParanoid	1	1.000	-	-		X1815
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800