Protein Alignment PTPRR and Ptp99A

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_651691.4
• Gene: Ptp99A / 43469
• FlyBaseID: FBgn0004369
• Length: 1397
• Species: Drosophila melanogaster
• Alignment Length: 759
• Identity: 185/759 - (24%)
• Similarity: 307/759 - (40%)
• Gaps: 194/759 - (25%)

Human    28 HFLAINQKKSGKPVFIYKHSQDIEKSLDIA-----PQKI------YRHSY--------------- 66
            :.:.:.:..:|||:....|:.. ..|:.|:     |..|      ||.:|
  Fly   233 YIVTLREAPTGKPIPTTAHNTS-STSVYISWKAPPPDTILGEFLGYRITYRPRDRDPNDTKEIYI 296

Human    67 -------HSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAM--DGQDLEVENLPI--PAANVIVVT 120
                   |.....|...::::....|......|...:|.|  :|...:.:||.|  .:||.|.::
  Fly   297 RDNTVESHEIQNLQTYTQYKVTVQVFNPEGLGPETTILVMTDEGVPSKPQNLTILDVSANSITMS 361

Human   121 LQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINR-----LIGKKNSIELFV-------SP---- 169
            .....|          :.|..|...:.  .:|.|:     :...:||:|..:       .|
  Fly   362 WHPPKN----------QNGAIAGYHVF--HIHDNQTGVEIVKNSRNSVETLIHFELQNLRPYTDY 414

Human   170 ---INRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQ--HEADKI---WSKE 226
               :...|..::..||:::.:..::.              .|....:...  |..:.|   |.:.
  Fly   415 RVIVKAFTTKNEGEPSDQIAQRTDVG--------------GPSAPAIVNLTCHSQESITIRWRRP 465

Human   227 -GFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPA-LSEAKTVHSM 289
             .||..:.|              |.:|.|.   ..||..::..|:.|...|:.| :.:..|.:|.
  Fly   466 YEFYNTIDF--------------YIIKTRL---AGQDTHRDIRINASAKELETAMILQNLTTNSY 513

Human   290 VQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDM--SSLGN 352
            .:.:.|....: |::|:.....:...:....:.|:..|::|:..|.....|:::.:.:  |..|.
  Fly   514 YEVKVAAATFS-VINPKKIVLGKFSESRIIQLQPNCEKLQPLLRQSHNDYNLAVLVGIIFSCFGI 577

Human   353 I-----------------------------EPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVA 388
            |                             .|.|....| .|:..| :::|..:   ::....||
  Fly   578 ILIIMAFFLWSRKCFHAAYYYLDDPPHHPNAPQVDWEVP-VKIGDE-IRAAVPV---NEFAKHVA 637

Human   389 SSH------------LLQSEFM--EIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRP--- 436
            |.|            .:|:|.:  ::|.     :....|.:..||||..|.....|||.|.|
  Fly   638 SLHADGDIGFSREYEAIQNECISDDLPC-----EHSQHPENKRKNRYLNITAYDHSRVHLHPTPG 697

Human   437 --KNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-N 498
              ||:     .|||||:|.||. |..|||.||||:.:|.|.||:|:|::...:|||||.|.|: .
  Fly   698 QKKNL-----DYINANFIDGYQ-KGHAFIGTQGPLPDTFDCFWRMIWEQRVAIIVMITNLVERGR 756

Human   499 EKCVLYWPEKRGI--YGKVEVLVISVNECDNYTIRNLVL--------KQGSHTQHVKHYWYTSWP 553
            .||.:||| |.|:  ||.::|.:|.......||:|.|.:        ||.:..:.|..|.||:||
  Fly   757 RKCDMYWP-KDGVETYGVIQVKLIEEEVMSTYTVRTLQIKHLKLKKKKQCNTEKLVYQYHYTNWP 820

Human   554 DHKTPDSAQPLLQLMLDVEEDRLASQGR-GPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDAL 617
            ||.|||...|:|..   |::...|:... ||:|||||||:||||.:|......:|::::.:|:..
  Fly   821 DHGTPDHPLPVLNF---VKKSSAANPAEAGPIVVHCSAGVGRTGTYIVLDAMLKQIQQKNIVNVF 882

Human   618 SIVCQLRMDRGGMVQTSEQYEFVHHAL----CLYESRLSAETVQ 657
            ..:..:|..|..:|||.|||.|:|.||    ...|:.|.||.|:
  Fly   883 GFLRHIRAQRNFLVQTEEQYIFLHDALVEAIASGETNLMAEQVE 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	98/241 (41%)
Ptp99A	NP_651691.4	FN3	140..236	CDD:238020	0/2 (0%)
		FN3	243..337	CDD:238020	16/94 (17%)
		fn3	343..430	CDD:394996	16/98 (16%)
		FN3	442..520	CDD:238020	18/94 (19%)
		R5-PTPc-1	704..907	CDD:350397	86/207 (42%)
		R5-PTP-2	989..1182	CDD:350398