Protein Alignment PTPRR and Ptp69D

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 658
• Identity: 165/658 - (25%)
• Similarity: 274/658 - (41%)
• Gaps: 131/658 - (19%)

Human    25 NNDHFLAINQKKSGKPVFIYKHSQDIEKS----LDIAPQKIYRHSYHSSSEAQVSKRHQIV---- 81
            |||:....:.:|.....:...||.::.:|    .::...|.:|.......|.:.|:.:.|:
  Fly   589 NNDNKELPDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEKRFSENNDIIRDND 653

Human    82 --------NSAF---PRPAYDPSLNLLAMDGQDL----EVENLPIPAANVIVVTLQMDVNKLNIT 131
                    .:.|   |...:.|....|:....:|    |.:|| |..||:....|::..:|
  Fly   654 EICRKCLEGTPFLRKPEIIHIPPQGSLSNSDSELPILSEKDNL-IKGANLTEHALKILESK---- 713

Human   132 LLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGISDALPSEEVLRSLNINVLHQ 196
             ||..|..|.:....:...|:.|..: ..:|.::|...|:..:..:..|  |.::|..| |.|..
  Fly   714 -LRDKRNAVTSDENPILSAVNPNVPL-HDSSRDVFDGEIDINSNYTGFL--EIIVRDRN-NALMA 773

Human   197 SLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVIIVTCLMILYRLKERFQLSLRQ 261
            ....|.|...:.|...:|..:..| .:...|..|..:.|.:.::.:...:..::
  Fly   774 YSKYFDIITPATEAEPIQSLNNMD-YYLSIGVKAGAVLLGVILVFIVLWVFHHK----------- 826

Human   262 DKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPF 326
             |.||:......:||:.:||.|
  Fly   827 -KTKNELQGEDTLTLRDSLSRA------------------------------------------- 847

Human   327 KMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAMEYLQSASRILTRSQLRDVVASSH 391
                  |..||..|.|   ...:.||.:.|.:.|..|..:...|         :::.:|   :.:
  Fly   848 ------LFGRRNHNHS---HFITSGNHKGFDAGPIHRLDLENAY---------KNRHKD---TDY 891

Human   392 LLQSEFMEIPMNFVD--PKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLST--YINANYI 452
            ....|:..:|..|.|  .|..|:..:..||||..|.....:||.|.   |.:.|.|  |||||::
  Fly   892 GFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLA---VINGLQTTDYINANFV 953

Human   453 RGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEK---RGIYG 513
            .||..::| ||..||||.:|:||||:|:|::...:|||:|.|:|.|: ||..|||||   ...:|
  Fly   954 IGYKERKK-FICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFG 1017

Human   514 KVEVLVISVNECDNYTIRNL-VLKQGSHT------QHVKHYWYTSWPDHKTPDSAQPLLQLMLDV 571
            .:.|......:..:|..|.| |.|..::.      :.:..|.|.:|.|...|:....:::.:..:
  Fly  1018 DILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQI 1082

Human   572 EEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQ 636
              :.:.|..|||::||||||:||||..:|.....|||:||..|...:.||.||..|..:||:.:|
  Fly  1083 --NSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQ 1145

Human   637 YEFVHHAL 644
            |.|::.||
  Fly  1146 YIFLYRAL 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	89/237 (38%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046
		fn3	237..321	CDD:394996
		FN3	<300..>524	CDD:442628
		PTPc	892..1155	CDD:214550	97/268 (36%)
		PTPc	1186..1449	CDD:214550