Protein Alignment PTPRR and Ptpmeg

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_612031.3
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Alignment Length: 787
• Identity: 176/787 - (22%)
• Similarity: 280/787 - (35%)
• Gaps: 261/787 - (33%)

Human    27 DHFLAINQKKS-------GKPVFIYKHSQDIEKS-------------------LDIAPQKIYRHS 65
            |.|:.:.::.|       |..:..:||::.:.||                   |:|:....:.:|
  Fly   277 DFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYS 341

Human    66 YHSSSEA-QVSKRHQIVNSAFPRPAYDPSLNLLAMDG-------------------QDLEVENLP 110
            ..:..:| |.||:...::..|.|   .||..||...|                   :.....|..
  Fly   342 GRTELQAVQESKQRGRIHKVFVR---SPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNG 403

Human   111 IPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTG 175
            .||....::|:..                        ..:.|.|::..|:
  Fly   404 KPAGAGTILTITK------------------------TSRPHDNKVTSKE--------------- 429

Human   176 ISDALP-------SEEVLRSLNINVLHQSLSQFGITEVSPEKNVL-QGQHEADKIWSKEGFYAVV 232
             :|::|       |:|....|::..:.|...:|.....||..... .|||..
  Fly   430 -ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSP------------- 480

Human   233 IFLSIFVIIVTCL--------------MILYRLKE----RFQLSLRQDKEKNQEIHLSPIT---- 275
                  :::.|.:              :|..||:.    |:..:::...:.:..:.:|.:.
  Fly   481 ------ILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTP 539

Human   276 ---LQPALSE--------AKTVHSMVQPEQAPKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMK 329
               ..|.:.|        .:.||.: :.||   |:.::.|.:.:.:.|:..|.      .|.:..
  Fly   540 ADRCTPRVCEGDEVLMINGRDVHGL-RHEQ---VVAMIRDCRHQASGELLLTV------RPQRSA 594

Human   330 PIGLQERRGSNVSLTLDMSSLGNIEP-FVSIPTPREKVAMEYLQSASRILTRS--QLRDVVASSH 391
            |:.|:|                  || :..:|...|..:...|.....:.|:|  .|.|.:||..
  Fly   595 PLLLEE------------------EPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGA 641

Human   392 LL-QSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGY 455
            || |.|.|......:...|...|.:..||||:.|.|...:||.|    |......||||||:...
  Fly   642 LLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL----VNSLTGDYINANYVNME 702

Human   456 --SGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-NEKCVLYWPEKRGIYGK--- 514
              .|....:||||||:.:|..|||:||.||.|.::||:|.:.|. .:||..|||    :.|:
  Fly   703 IPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWP----VTGEELQ 763

Human   515 ------VEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQ------- 566
                  |..|....:|..::..|..|||.....:|:.|..|.:||||..|......|:
  Fly   764 LAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRA 828

Human   567 -----LMLDVEED----RL--------------------ASQG--------------------RG 582
                 |:.::||.    ||                    ||.|                    ..
  Fly   829 ARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANP 893

Human   583 PVVVHCSAGIGRTGCFIA--TSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALC 645
            ||:|||||||||||..|.  |::...:.:|.  |..|.||..:|..|..|||...||.||...:|
  Fly   894 PVIVHCSAGIGRTGVLILMDTALALMEAREP--VYPLDIVRTMRDQRACMVQNVSQYRFVCECIC 956

Human   646 LYESRLS 652
            ....::|
  Fly   957 AAYMKIS 963

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	95/294 (32%)
Ptpmeg	NP_612031.3	B41	35..232	CDD:214604
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	8/42 (19%)
		FA	333..369	CDD:462582	9/38 (24%)
		PDZ_PTPN3-4-like	500..589	CDD:467190	15/98 (15%)
		PTPc-N3_4	692..961	CDD:350389	86/274 (31%)