Protein Alignment PTPRR and PTP-ER

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 1004
• Identity: 215/1004 - (21%)
• Similarity: 299/1004 - (29%)
• Gaps: 498/1004 - (49%)

Human    56 IAPQKIYRHS--YHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEVENLPIPA--ANV 116
            :||:..::|:  .||||....:....:....|......|..:.......|     ||:|.  |..
  Fly   462 LAPRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGGPKESPFKQKSMD-----LPMPTLQAKT 521

Human   117 IVVTLQMDV-----NKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPINRKTGI 176
            .|.|..|::     :..::||......|.....||......:..::..|:|..|.....::..
  Fly   522 TVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSNYSLGSILNSKSSCNLDAGTASQIR-- 584

Human   177 SDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFVII 241
            :|.||...:|.|                        .||        |::|.:
  Fly   585 ADQLPQSHLLGS------------------------SQG--------SRQGLF------------ 605

Human   242 VTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVH---------SMVQPEQAPK 297
                               :.:..|..|.|            ||.|         ||.|.:|...
  Fly   606 -------------------RRRGSNHSITL------------KTGHTTTSCGDLNSMQQLQQQQA 639

Human   298 V--------LNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSS-LGN- 352
            :        ||:..:..|.|      :.:.|..|:|.:    ||.||||||.||||:|.| ||.
  Fly   640 MLSAEKYNRLNMRTNSTGSG------SGSGSNVPTPKR----GLLERRGSNQSLTLNMGSILGGA 694

Human   353 ----------IEPFVSI--------------------------------------------PTPR 363
                      ::|.|::                                            |.|:
  Fly   695 AGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKFFGQVCFGSASDLQPNPQ 759

Human   364 EK---------------------------------------VAMEYLQSASRILTRSQL------ 383
            :.                                       .:::.|||||..|.:..|
  Fly   760 QDSVREDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYV 824

Human   384 --------RDVVASSHLLQSEF--MEIPMNFVDP------------------------------- 407
                    |:::....:|.|..  :|.|.:.|.|
  Fly   825 FDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLASYQTVVSRMAQPIPELKENEQK 889

Human   408 -------KEI-DIPRH----------GTKNRYKTILPNPLSRVCL---------------RPKNV 439
                   ||. |:|.:          .|||||||||||..|||.|               |..:|
  Fly   890 RIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSV 954

Human   440 TDSLS-TYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQ--------------EDSP--- 486
            |.|.. .|||||||:|.....|.::|||||:.||:.:||.|::|              ..||
  Fly   955 TASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVD 1019

Human   487 ----------VIVMITKLKEKN-EKCVLYWP----EKRGIYGKVEVLVISVNECD---------- 526
                      .|||:|...|.| :||.:|:|    |...:..|.||..:|....|
  Fly  1020 REQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTF 1084

Human   527 --------------------------------------------------------NYTIRNLVL 535
                                                                    .|::|.|||
  Fly  1085 VPDTVVASSDAIDYEISGRHIGVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVL 1149

Human   536 --------KQGSHTQHV--KHYWYTSWPDHKTPDSAQPLLQLML------------DVEED---- 574
                    ....|.|.:  .||||..||||.:|.....||...|            |:.:|
  Fly  1150 LYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSE 1214

Human   575 ---RLASQ-----------GRGPV-VVHCSAGIGRTGCFIATSIGCQQLKE-------------- 610
               .||:|           ...|: |:||||||||||||.|.....:||::
  Fly  1215 RNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSL 1279

Human   611 -----------------------------------EGV----------------VDALSIVCQLR 624
                                               |.|                ||.|.|||.||
  Fly  1280 TSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLR 1344

Human   625 MDRGGMVQTSEQYEFVHHALCLYESRLSA 653
            :.||||||.|||||.:|.|:|||..|..|
  Fly  1345 LQRGGMVQNSEQYELIHRAICLYLKRTLA 1373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	119/444 (27%)
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	117/442 (26%)