Protein Alignment PTPRR and Pez

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Alignment Length: 710
• Identity: 144/710 - (20%)
• Similarity: 243/710 - (34%)
• Gaps: 207/710 - (29%)

Human    18 AAGCFSGNNDHFLAINQKKSGKPVFIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVN 82
            ||...:|:     .:.|.....|...|:.|.....|..: |..:...|:.|::.|.:.:  .:||
  Fly   669 AAAAAAGS-----VVTQSSPTLPPSGYRSSVPPPASSPL-PPPVVASSHKSATPAPLQR--SLVN 725

Human    83 SAFPRPAYD-------------PSLNLLAMDGQDLEVEN----LPIPAA------NVIVVTLQMD 124
            .:. .|.|:             .:.|..||..:...:::    :|:|||      ||:.||:...
  Fly   726 GSI-EPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSP 789

Human   125 VNKLNITLLRIFRQGVAAALGLL-------------------------PQQVHINRLIGKKNSIE 164
            .:..||   :.:....||:..||                         |:|......:.|.::::
  Fly   790 PDDGNI---KKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVD 851

Human   165 LFVSPINRKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNVLQGQHEADKIWSKEGFY 229
            :.       |...|.|..:....:|:.|....:.|.|..|..:...:......:..|.|:
  Fly   852 MI-------TPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWN----- 904

Human   230 AVVIFLSIFVIIVTCLMILYRLKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQ 294
                |||                    .|...||:|:..:
  Fly   905 ----FLS--------------------RSKTPDKQKSATL------------------------- 920

Human   295 APKVLNVVVDPQGRGAPEIKATTATSVCPSPFKMKPIGLQERRGSNVSLTLDMSSLGN-IEPFVS 358
                        ||.    |||||             |...:..:.:.|..|..:|.| ....|:
  Fly   921 ------------GRE----KATTA-------------GQHSKLAAKLKLAQDDLNLPNRWSTGVN 956

Human   359 IPTPREKVAMEYLQSASRILTRSQLRDVVASSHLLQSEFMEIPMN---------FVDPKEIDIPR 414
            .|.|   ::..|  |..::   .|:.|...|...|..||..||..         .::..|
  Fly   957 KPQP---ISGRY--SKDKL---CQILDQKLSDSQLFMEFERIPKRREHALYECALLEENE----- 1008

Human   415 HGTKNRYKTILPNPLSRVCLRPKNVTDSLSTYINANYIRGYSG-KEKAFIATQGPMIN-TVDDFW 477
              .||.....||...:||.|.|  ..|:...|:||:.|....| |::.:|..|.|... |:..||
  Fly  1009 --PKNHDPNFLPYDDNRVRLTP--CRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFW 1069

Human   478 QMVWQEDSPVIVMITKLKEKNEKCVLYWP---EKRGIYGKVEVLVISVNECDNYTIRNLVLKQGS 539
            |.||:.|..::|.:|       :.:.|.|   .:|..:|:.:|    ..|....|.|...:|...
  Fly  1070 QCVWEADVYLVVQLT-------EDMSYIPRNSHQRLEFGQFQV----YQEFSQTTDRCTTIKLRL 1123

Human   540 H---TQHVKHYW---YTSWPDHKTPDSAQPLLQLMLDVEEDRLAS--------QGRGPVVVHCSA 590
            :   ::..:..|   |..|.:...|......|..:.::...||||        ....||::||..
  Fly  1124 YHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLE 1188

Human   591 GIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMDRGGMVQTSEQYEFVHHALCLYESR 650
            |.||:|..:...:....|.....:|...::.|||..|..::.:..||:|:::.|..|..|
  Fly  1189 GGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKR 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	62/243 (26%)
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	54/220 (25%)