Protein Alignment PTPRR and Ptp10D

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_996413.2
• Gene: Ptp10D / 32115
• FlyBaseID: FBgn0004370
• Length: 1990
• Species: Drosophila melanogaster
• Alignment Length: 733
• Identity: 181/733 - (24%)
• Similarity: 297/733 - (40%)
• Gaps: 161/733 - (21%)

Human    45 KHSQDIEKSL---DIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEV 106
            |.:.|.::.:   .:.|.::|..:..:.|....|...|..:..:|    :|...|.|.:..|.|:
  Fly   820 KLANDTDRKVTFTGLVPGRLYNITVWTVSGGVASLPIQRQDRLYP----EPITQLHATNITDTEI 880

Human   107 E---NLP-----------IPAANVIVVTL----QMDVNKL----NITLLRIFRQGVAAAL----G 145
            .   :||           :.|.|::...:    ::.::.|    |.|...:.|.|..:::    .
  Fly   881 SLRWDLPKGEYNDFDIAYLTADNLLAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSS 945

Human   146 LLPQQVHINRLIGKKNSIELF----VSPINRKTGISDALPSEE---VLRSLNI---NVLHQSLSQ 200
            .|......|..:  ...:|.|    |.|  .:.....:|||.|   |:|..:|   |:  .:|:.
  Fly   946 PLSASFTTNEAV--PGRVERFHPTDVQP--SEINFEWSLPSSEANGVIRQFSIAYTNI--NNLTD 1004

Human   201 FGITEVSPE------KNVLQGQHEADKIWSKE--GFYAVVIFLSIFVIIV-------TCLMILYR 250
            .|:.:...|      ||:..|:....||.:|.  ||.....:.....|:.       .....:||
  Fly  1005 AGMQDFESEEAFGVIKNLKPGETYVFKIQAKTAIGFGPEREYRQTMPILAPPRPATQVVPTEVYR 1069

Human   251 LKERFQLSLRQDKEKNQEIHLSPITLQPALSEAKTVHSMVQPEQAPKVLNV----------VVDP 305
            .....|:..|::...:|...:...|:..|..:||....:    :.|..|:|          .:||
  Fly  1070 SSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDDAKNASGL----EMPSWLDVQSYSVWLPYQAIDP 1130

Human   306 ----QGRGAPEIKATTAT------SVCPSPFKMKP---IGLQERRGSN----------VSLTLDM 347
                :.|...:....|..      ..|..|.|...   :.::...|::          :....|.
  Fly  1131 YYPFENRSVEDFTIGTENCDNHKIGYCNGPLKSGTTYRVKVRAFTGADKFTDTAYSFPIQTDQDN 1195

Human   348 SSLGNIEPFVSIPTP---------------REKVAMEYLQSASRILTRSQLRDVV---------- 387
            :||     .|:|..|               |.:.........||......|.|.|
  Fly  1196 TSL-----IVAITVPLTIILVLLVTLLFYKRRRNNCRKTTKDSRANDNMSLPDSVIEQNRPILIK 1255

Human   388 --ASSHLLQS---------EFMEI-------PMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCL 434
              |..:.|.|         ||.|:       |..|.     |:|.:..|||:..|||...||..|
  Fly  1256 NFAEHYRLMSADSDFRFSEEFEELKHVGRDQPCTFA-----DLPCNRPKNRFTNILPYDHSRFKL 1315

Human   435 RPKNVTDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEK-N 498
            :|.: .|..|.||||||:.|:: ..:.||.||||:.:|.||||:|.|:.:|..|||:|:..|| .
  Fly  1316 QPVD-DDEGSDYINANYVPGHN-SPREFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGR 1378

Human   499 EKCVLYWPEKR--GIYGKVEVLVISVNECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSA 561
            |||..|||...  ..||.::|.:::.:...::.:...:|.:||..:.::|:.:|:|||...|:..
  Fly  1379 EKCDQYWPNDTVPVFYGDIKVQILNDSHYADWVMTEFMLCRGSEQRILRHFHFTTWPDFGVPNPP 1443

Human   562 QPLLQLMLDVEEDRLASQGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRMD 626
            |.|:: .:....||:.::.| |:|||||||:||:|.||......||:.....||...||..:|.:
  Fly  1444 QTLVR-FVRAFRDRIGAEQR-PIVVHCSAGVGRSGTFITLDRILQQINTSDYVDIFGIVYAMRKE 1506

Human   627 RGGMVQTSEQYEFVHHAL 644
            |..||||.:||..:|..|
  Fly  1507 RVWMVQTEQQYICIHQCL 1524

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	89/227 (39%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:394996
		fn3	220..304	CDD:394996
		FN3	278..>734	CDD:442628
		FN3	583..671	CDD:238020
		fn3	787..850	CDD:394996	5/29 (17%)
		fn3	866..935	CDD:394996	13/68 (19%)
		fn3	959..1043	CDD:394996	23/87 (26%)
		PTP_tm	1083..1187	CDD:465889	16/107 (15%)
		R3-PTPc	1301..1522	CDD:350396	87/224 (39%)