Protein Alignment PTPRR and Ptpmeg2

DIOPT Version :10

• Sequence 1: NP_002840.2
• Gene: PTPRR / 5801
• HGNCID: 9680
• Length: 657
• Species: Homo sapiens
• Sequence 2: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 756
• Identity: 182/756 - (24%)
• Similarity: 283/756 - (37%)
• Gaps: 208/756 - (27%)

Human    42 FIYKHSQDIEKSLDIAPQKIYRHSYHSSSEAQVSKRHQIVNSAFPRPAYDPSLNLLAMDGQDLEV 106
            |:|....||.:::.:..|           ..|:..:..:.|       .||.:..|..:.|..:.
  Fly   126 FLYARKFDIPRAVSLYEQ-----------HEQIRLKEYLYN-------IDPDVEPLRSELQTGKF 172

Human   107 ENLPIPAANVIVVTLQMDVNKLNITLLRIFRQGVAAALGLLPQQVHINRLIGKKNSIELFVSPIN 171
            ..||.                         |....||:.|.....|....:....:::..|..::
  Fly   173 TILPA-------------------------RTSSGAAIALFTANRHSPLSVSHTTTLQGIVYQLD 212

Human   172 RKTGISDALPSEEVLRSLNINVLHQSLSQFGITEVSPEKNV---LQGQHEA---------DKIWS 224
                  .||...|..|:..:.:...|.|::...:....:.:   |:|.:.|         ..:|.
  Fly   213 ------SALQDSETQRAGLVFIYDMSGSKYSNFDYDLSQKILTLLKGGYPARLKKVLIVTAPLWF 271

Human   225 KEGFYAVVIFL------SIFVIIVTCLMILYRLK--------------ERFQLSLRQDKEKNQEI 269
            |..|..:.:|:      .:|.:.|..|.:....|              ..:.||.||.....::.
  Fly   272 KAPFKILRLFVREKLRERVFTVSVPQLALHVPRKALPIHLGGTLEVDHATWLLSCRQSMTNREDE 336

Human   270 HLSPI-----------------------TLQPALSEAKTVHSMVQP--EQAPKVLNVV--VDPQG 307
            .|:.|                       |...|.:.|.|:.|.|..  :....|:.|.  |.|.|
  Fly   337 LLANIVGVGGGSGSGSAAGSAAIVSTNGTETEAATTAATIISAVHQLGDNNTTVVTVSNGVGPAG 401

Human   308 RGAPEIKATTATSVCPSP---FKMKPIGLQERRGSNVSLTLDMSSLGNIEPFVSIPTPREKVAME 369
            ..:.  .||||.|....|   ..:..:....|:.:|.|.:...|:       .::..|.:
  Fly   402 SASG--GATTAASAATEPNENITINGLSPSHRQAANNSSSSSSSA-------ATVANPLK----- 452

Human   370 YLQSASRILTRSQLRDVVASSHLLQS----------EF-MEIPMNFV---------------DPK 408
             |.::......|.:.:...::....:          || .|.|.:..               |||
  Fly   453 -LNTSGSADNNSTITNATTAAGAAGAAAGTTTNGGGEFWSENPPSSASSGFSDDDSLAGQEGDPK 516

Human   409 EID--------IPRHG--------------------------TKNRYKTILPNPLSRVCLRPKNV 439
            .||        ..|||                          |||||..:|....|||.|..::
  Fly   517 PIDQIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTKNRYTDVLCYDHSRVVLAHED- 580

Human   440 TDSLSTYINANYIRGYSGKEKAFIATQGPMINTVDDFWQMVWQEDSPVIVMITKLKEKNE-KCVL 503
            .|..|.|||||::.||..| .|:|:||||:..|..|||:|:|::...||||.|::.|:.. ||..
  Fly   581 GDEPSDYINANFVDGYKQK-NAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQ 644

Human   504 YW--PEKRGI-YGKVEVLVISVNEC-DNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQ 562
            ||  .|:..: :|...|..||| || ::|.:.:|.|:  :....::|.|:.:|||||:..|.||.
  Fly   645 YWEPTEESSLEFGDYHVRTISV-ECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSAM 708

Human   563 PLLQLMLDVEE----------DRLASQGRG-PVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDA 616
            .:|..:..|.|          |..|...|| |:||||||||||||.||...|...:|::.|..|.
  Fly   709 AMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRLEDVGTADI 773

Human   617 LSIVCQLRMDRGGMVQTSEQYEFVHHALCLYE-SRLSAETV 656
            ...|.::|..|...:|..:||.|.|.||..|. ||...:||
  Fly   774 RGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTV 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRR	NP_002840.2	R-PTPc-R	417..642	CDD:350459	96/242 (40%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024	5/28 (18%)
		SEC14	170..314	CDD:469559	25/174 (14%)
		PTPc-N9	529..799	CDD:350391	99/272 (36%)