Protein Alignment PTPRO and csw

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 633
• Identity: 151/633 - (23%)
• Similarity: 229/633 - (36%)
• Gaps: 240/633 - (37%)

Human   769 EPVAVSSHVVTISSL-----LPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAI 828
            :|.|.:|...:..||     .|..:|..:.||::...|..|.....::...         |.|::
  Fly   143 QPSAAASASTSTESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGASCSN---------STLSL 198

Human   829 LSTLLIGLLLVT-------------LIILRKKH---LQMARECGAGTFVNFASLERDGKLPYNWR 877
            |:|:.:.|...|             ||:.|.|:   |....:...|.||  .|:..|.|:.:...
  Fly   199 LATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKPGDFV--LSVRTDDKVTHVMI 261

Human   878 RSIFAFLTLLPSCLWTDY-----------LLAFYINPWSKNGLKK--------RKLTNPVQLD-- 921
            |             |.|.           .|:..|:.:.:|.:.:        |:..|..::.
  Fly   262 R-------------WQDKKYDVGGGESFGTLSELIDHYKRNPMVETCGTVVHLRQPFNATRITAA 313

Human   922 DFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAAD---LPLNRCKNRYTNILPYDFSRVRLVS 983
            ..:|.::.:.|..   |..:||.|:....|.  |:.:   ...||.||||.||||||.:||:|:.
  Fly   314 GINARVEQLVKGG---FWEEFESLQQDSRDT--FSRNEGYKQENRLKNRYRNILPYDHTRVKLLD 373

Human   984 MNEE-EGADYINANYI------------------------------------------------- 998
            :... .||:|||||||
  Fly   374 VEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQLQNKTCVQ 438

Human   999 --------------------------------------------PG---------YNSP------ 1004
                                                        ||         .|.|
  Fly   439 CAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGVSSVNGPGTPTNL 503

Human  1005 ---------------------------------------QEYIATQGPL----PETRNDFWKMVL 1026
                                                   :.||||||.|    ..|..|||.||.
  Fly   504 TSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQVNTVTDFWNMVW 568

Human  1027 QQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADE-MQ 1090
            |:.:::|||.|:..|:.:.||..|||.......:|...::.:||....|:..|.|.:::.|: .:
  Fly   569 QENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENSTSDYTLREFLVSWRDQPAR 633

Human  1091 DVMHFNYTAWPDHGVPTANAAESILQFVHMV--RQ----QATKSKGPMIIHCSAGVGRTGTFIAL 1149
            .:.|:::..|||||||.....  :|.|:..|  ||    ||.:..||:.:|||||:|||||||.:
  Fly   634 RIFHYHFQVWPDHGVPADPGC--VLNFLQDVNTRQSHLAQAGEKPGPICVHCSAGIGRTGTFIVI 696

Human  1150 DRLLQHI----RDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQ 1193
            |.:|..|    .|.| :||...:..:||.|..:||||.||.|::..||
  Fly   697 DMILDQIVRNGLDTE-IDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQ 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996
		FN3	530..630	CDD:238020
		fn3	725..805	CDD:394996	10/40 (25%)
		R-PTPc-O	951..1195	CDD:350462	109/409 (27%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	18/110 (16%)
		PTPc-N11_6	352..748	CDD:350392	107/395 (27%)