Protein Alignment PTPRO and Ptp69D

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1381
• Identity: 290/1381 - (20%)
• Similarity: 492/1381 - (35%)
• Gaps: 451/1381 - (32%)

Human    21 FVLFKNATA-FHVTVQDDNNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIF 84
            |:.:||..| ..|.::|..|...:.:               ||::.:..|:...:   ||..|:
  Fly    90 FIKYKNVLALLDVNIKDSGNYTCTAQ---------------TGQNHSTEFQVRPY---LPSKVL- 135

Human    85 KASYHGLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVLFEIHYPEKYNV 149
                                .:.|.|     .|......|.:|         .|.|: ||:  |.
  Fly   136 --------------------QSTPDR-----IKRKIKQDVMLY---------CLIEM-YPQ--NE 163

Human   150 FTRVNISYW--EGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLV-----SEATFNKSTLVE 207
            .|..|:. |  :|..|.   :.|.|...:..|.     .:.|.|.:..     ...|: |.|:.:
  Fly   164 TTNRNLK-WLKDGSQFE---FLDTFSSISKLND-----THLNFTLEFTEVYKKENGTY-KCTVFD 218

Human   208 YSGVSHEPKQHRTAPYPPQNISV---RIVNLNK--NNWEEQSGNFPEESFMRSQDTIGKEK---- 263
            .:|:....|:..........:|:   :.|..||  .||....||.|.:.|..:....|...
  Fly   219 DTGLEITSKEITLFVMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPIQKFFITLQEAGTPTFTYH 283

Human   264 ------------LFHFTEETPE----IPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDE 312
                        |.||...|..    :...:|.:|.|         |..|
  Fly   284 KDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQP---------TQYP--------------- 324

Human   313 FVSVLPMEYENNSTLS---------ETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIERE 368
                     :..:|||         ||..||:.:.:       :.|.|| ||...|
  Fly   325 ---------QGITTLSYDPIFIPKVETTGSTASTIT-------IGWNPP-PPDLID--------- 363

Human   369 ENFTEY--LMVDEEAHEFVAELKEPGKY------------KLSVTTFSSSGSCETRKSQSAKSLS 419
              :.:|  |:|.|...  |.::.|...|            ||...|     ..|.|    .::.|
  Fly   364 --YIQYYELIVSESGE--VPKVIEEAIYQQNSRNLPYMFDKLKTAT-----DYEFR----VRACS 415

Human   420 FYISPSGEWIEE--------LTEKPQHVSV-----HVLSSTTALMSWTSSQENYNSTIVSVVSL- 470
            ......|.|.|.        :..||.::|:     :|....:..::|...:......:..::.|
  Fly   416 DLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYLIHLL 480

Human   471 -----TCQKQ---KESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVI-----YLRKGPLIGPPSD 522
                 |..::   .:.:|:::.:      .|.:.|::.|...|.|.:     :.:.|       :
  Fly   481 GNPMSTVDREMWGPKIRRIDEPH------HKTLYESVSPNTNYTVTVSAITRHKKNG-------E 532

Human   523 PVT-FAIVPTGIKDLMLYPLGPTAVVLSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTY--YEIA 584
            |.| ..::|....|    .:|.|    .|::  :.:..|||::::....:........|  |
  Fly   533 PATGSCLMPVSTPD----AIGRT----MWSK--VNLDSKYVLKLYLPKISERNGPICCYRLY--- 584

Human   585 ATVSLTASVRIAN---LLPAWYYNFRVTMVTWGDPE-LSCC-----DSSTISFITAPVAPEITSV 640
                   .|||.|   .||              ||| |:..     .|..::..:|.:| |:.|.
  Fly   585 -------LVRINNDNKELP--------------DPEKLNIATYQEVHSDNVTRSSAYIA-EMISS 627

Human   641 EYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTA 705
            :||...:::    ||:                       |..:.|          .||...:...
  Fly   628 KYFRPEIFL----GDE-----------------------KRFSEN----------NDIIRDNDEI 655

Human   706 CTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEP 770
            |.:....|..||..::...||:.  :::.:.:.:.:|                   |:|..|.:.
  Fly   656 CRKCLEGTPFLRKPEIIHIPPQG--SLSNSDSELPIL-------------------SEKDNLIKG 699

Human   771 VAVSSHVVTISSLLPATAYNCSVTS-----FSHDSPSVP-------------------------- 804
            ..::.|.:.|.........| :|||     .|..:|:||
  Fly   700 ANLTEHALKILESKLRDKRN-AVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEII 763

Human   805 ------------TFIAVSTMVTEMNP-----NV-VVISVLAILSTLLIGLLLVTLIILRKKHLQM 851
                        .:..:.|..||..|     |: ..:|:......:|:|::||.:::....|.:.
  Fly   764 VRDRNNALMAYSKYFDIITPATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKT 828

Human   852 AREC-GAGTFVNFASLERD--GKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRK 913
            ..|. |..|.....||.|.  |:..:|...    |:|                     :|..|..
  Fly   829 KNELQGEDTLTLRDSLSRALFGRRNHNHSH----FIT---------------------SGNHKGF 868

Human   914 LTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSR 978
            ...|:...|.:...|:..||:||.|..::|.|.....|.....:||..|.|||||.:|..||.:|
  Fly   869 DAGPIHRLDLENAYKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTR 933

Human   979 VRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKR 1043
            |:|..:|..:..||||||::.||...:::|..|||:..|.:|||:|:.:|..:||||||...|..
  Fly   934 VKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYN 998

Human  1044 RVKCDHYWPFTEEPI----AYGDITVEMISEEEQDDWACRHFRI--NYA-----DEMQDVMHFNY 1097
            :.||..|||   |.:    .:|||.|:...|.:..|:..|...:  |.|     ::.:.:..::|
  Fly   999 KAKCAKYWP---EKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHY 1060

Human  1098 TAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFV 1162
            ..|.|...|  .....|::|:..:....:..:||:::|||||||||||.:|||.|:|.:.:.:.|
  Fly  1061 LTWKDFMAP--EHPHGIIKFIRQINSVYSLQRGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSV 1123

Human  1163 DILGLVSEMRSYRMSMVQTEEQYIFIHQ-------------CVQLM-----WMKKK--QQFCISD 1207
            .|...|.::|..|..:||:.:||||:::             |:..|     .:|:|  :..|..:
  Fly  1124 SIYNTVCDLRHQRNFLVQSLKQYIFLYRALLDTGTFGNTDICIDTMASAIESLKRKPNEGKCKLE 1188

Human  1208 VIYE-------NVSKS 1216
            |.:|       .:|||
  Fly  1189 VEFEKLLATADEISKS 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996	14/104 (13%)
		FN3	530..630	CDD:238020	21/110 (19%)
		fn3	725..805	CDD:394996	16/122 (13%)
		R-PTPc-O	951..1195	CDD:350462	92/267 (34%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046	7/23 (30%)
		Ig_3	134..216	CDD:464046	23/129 (18%)
		fn3	237..321	CDD:394996	18/92 (20%)
		FN3	<300..>524	CDD:442628	48/292 (16%)
		PTPc	892..1155	CDD:214550	94/267 (35%)
		PTPc	1186..1449	CDD:214550	5/19 (26%)