Protein Alignment PTPRO and Ptp52F

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_611093.2
• Gene: Ptp52F / 36790
• FlyBaseID: FBgn0034085
• Length: 1433
• Species: Drosophila melanogaster
• Alignment Length: 1505
• Identity: 330/1505 - (21%)
• Similarity: 543/1505 - (36%)
• Gaps: 493/1505 - (32%)

Human     8 IHGARRLLPLLWLFVLFKNATAFHVTVQDDNNIVVSLEASDVISPASVYVV--KITGES------ 64
            ||.   |:.:||:..:........|.|.:...:...:|.:.|   ::||.:  .|:.|:
  Fly    13 IHA---LILILWIAGVQGQTVGSLVAVSESQELAEKVEVTVV---STVYTLGFSISNEADYSIDK 71

Human    65 ------------KNYFFEFEEFNSTLPPPVIFKASYHGLYYIITLVVVNGNVVTKPSRSITVLTK 117
                        .|.....|..|     |..|..|         :|....||..||
  Fly    72 VICRNGSGSETEANAAHVCENLN-----PCTFYTS---------VVSFRSNVSGKP--------- 113

Human   118 PLPVTSVSIY---DYKPSPETGVLFEIHYPEKYNVFTRVNISYWEGKDFR-------TMLYKDFF 172
              |.:..:||   :|| .|:|.|...:.......|       .|:..|..       |....|:.
  Fly   114 --PPSDQTIYAYTEYK-QPKTTVTSVVATANTIKV-------TWQTNDRACVESFGITAKATDYT 168

Human   173 KGKTVFNHWLPGMCYSNITFQLVSEATF----NKSTLVEYSGVSHEPKQHRTAPYPPQNISVRIV 233
            |...:.|. .....:.|::..|....|.    |.|.:|:......:     |....|.::.:.:.
  Fly   169 KSFQLLND-KSSQTFVNLSACLTHTITLDTRNNASVVVDTDATDVD-----TQYAEPGDLVMNVT 227

Human   234 NLNKN----NWEEQSGNFPEESFM-----------RSQDTIGKEKLFHFTEE-----------TP 272
            ||...    .|.:.|......:::           ::|||.........|.|           ||
  Fly   228 NLASGITMITWGDPSEKNCISNYVFKWQRNDCGTDQNQDTTTDVPSTETTNEIDYVTTTPMETTP 292

Human   273 EIPSGNISSGWPDFNSS----DYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNS-----TLS 328
            :.||..:...|.|.:|.    :|..|      |.......:...|::      ||::     |.:
  Fly   293 DTPSDEVKCEWTDVSSDGKLREYLLT------DLQGCDLYTFQVFIN------ENSTAKASQTFT 345

Human   329 ETEKSTSGSF----SFFPVQMILTWLPPK-PPTAFDGFHI----HIEREENFTEYLMVDEEAHEF 384
            ..||..|..:    :.:|.|:..||..|: .|.....:.:    .|:|.||.| ..::.||....
  Fly   346 SAEKLVSAVYEPSPTAYPTQLHWTWFSPQNHPKCVANYSVTLTGPIQRSENKT-MNVITEETFAI 409

Human   385 VAELKEPGKYKLSVTTFSSSGSCETR-KSQS----------------AKSLSFYIS---P----- 424
            ..:|...|.|.:.:.....:||..|: :.||                |::.|..:|   |
  Fly   410 FDDLDPCGIYLVEIVPNQLNGSAGTKYQEQSTVGEDQPSVIQDPVVEAEAYSMEVSWKTPEYADL 474

Human   425 -------SGEWIEELTEKPQHVSVHVLSSTT---------------------------------- 448
                   || |:|:    .:.|.|..||.||
  Fly   475 CIDGYRLSG-WMED----DKLVEVEALSITTQNTTVVFDKNLLACQVYIIQIIPYTKENLDGQLR 534

Human   449 --------ALMSWT-----------------SSQENYNSTIVSVVSL-TCQ-----KQKESQRLE 482
                    |::.:|                 :...:||::..::.:| ||.     :...::|..
  Fly   535 QVGVETKAAIVDYTKVKLEMKNAGSEFIDLIAFNADYNNSCPTIFALFTCNATTQVRNPYAERYV 599

Human   483 KQYCTQ-VNSSKPIIENLVPGAQY--QVVIYLRKGPLIGPPSDPVTFAIVPTGIKDLMLYPLGPT 544
            :.:..| .|:|   :..|.|.|.|  :|::|...|     ||:||..|.:.|    ...:|..|.
  Fly   600 EGHSKQGFNAS---LSPLSPYATYVCKVILYNVAG-----PSEPVVDADMHT----TTYFPEQPE 652

Human   545 AVVLSWTRPYLGVFRKYVVEMFYFN--PATMTSEWTTYYE-----------IAATVSLT------ 590
            :|:|          .|..|....||  |.|.|:....||:           :.|..::.
  Fly   653 SVML----------EKSTVSSLLFNWQPPTYTNGPIKYYQAFLMRHEASYFVPADCAIVEQDTKS 707

Human   591 -----ASVRIANLLPAWYYNFRVT------MVTWGDPELSCCDSSTISFITAP-VAPEITSVEYF 643
                 .||....|.||..|..:|.      |..:.:|.:.         ||.| |:..:|.:...
  Fly   708 ETKGDPSVNFTGLAPAVRYMMQVAAQNDFGMGVYTEPVIG---------ITLPAVSDSVTQLTVL 763

Human   644 ------NSLLY-----ISW-----TYGD-------------DTTDLSHSRMLHWMVVAEGKKKIK 679
                  |:.:|     |:|     :.||             :...:|..|.:.   :..|.|:.:
  Fly   764 TQGPVNNNAVYEANVTITWKVPCKSNGDIEYFQLAFNGTRNNFAPVSFERRVE---LDTGNKQGR 825

Human   680 KSVTRNVM------TAILSLPPGDIYNLS------------------------VTACTERGSNTS 714
            .|.|...|      |..:|:...|:..||                        :.|..|..||.:
  Fly   826 MSYTETEMQPQFDYTVEVSVKNRDVEQLSSSVPGSWQSPAGLPTIPSDELIKQMRANVEETSNPT 890

Human   715 MLRLVKLEPAPPKSLFAVNKTQTSVTLLWVE--------EGV--------ADFFEVFC-QQVGSS 762
            ...:|:|    |..:.    |..|..:.|:.        .||        :|:.:|.. |:.|:.
  Fly   891 KTAIVRL----PADIM----TSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGAD 947

Human   763 ---------QKTKLQ---EPV-------AVSSH---VVTI--------------SSLLPATAYNC 791
                     |.|:.:   |||       .|:|.   |.||              ..|||.|.||.
  Fly   948 GTGDCSLEYQTTEERWHPEPVQRQRRDGEVTSDEEIVFTIGLDKCSEVQKTYCNGPLLPDTDYNV 1012

Human   792 SVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMARECG 856
            .|..|:....|   ..||....|:....|.:| ::::.|.||:..:|...::..:|.|...|:.|
  Fly  1013 VVRLFTASGYS---DAAVLNFKTKAAIKVTLI-LVSVCSCLLLAFVLGLTVLWVRKRLAWKRDSG 1073

Human   857 AGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFYINPWSKNGLKKRKLTNPVQLD 921
            .|....|.                                     |..:||
  Fly  1074 QGIEDPFG-------------------------------------NVIAKN-------------- 1087

Human   922 DFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYDFSRVRLVSMNE 986
             |..:..::||..  |.:.:|:|:.::.|::.:.|::|..:  ||||.:|.|||.:||.|..  :
  Fly  1088 -FAIFYTEVAKPE--KLAREFKEITVVALELSYSASELGCH--KNRYADIFPYDKNRVILDI--D 1145

Human   987 EEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQCNEKRRVKCDHYW 1051
            .||:|||||::|.|:...:||||||||.||:..|||:|:||...::||.:||..|...:||..|:
  Fly  1146 AEGSDYINASFIDGHTRKKEYIATQGPKPESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYY 1210

Human  1052 PFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESILQ 1116
            |:....:.....:.|::...::.:....|.:....::   |:|:.:..|||||||  .....::.
  Fly  1211 PYNVRGLTVTIKSKEVLELYDRTELTVVHDKYGLKEK---VIHYYFKKWPDHGVP--EDPMHLIM 1270

Human  1117 FVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQT 1181
            ||..|:.:...|..|:::|||||||||||||.||.::|.::....::|...|.::|..||.||||
  Fly  1271 FVKKVKAEKRPSYSPIVVHCSAGVGRTGTFIGLDLIMQRLKSESKINIFETVKKLRFQRMKMVQT 1335

Human  1182 EEQYIFIHQC 1191
            ::||.|::.|
  Fly  1336 QQQYTFLYAC 1345

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996	24/153 (16%)
		FN3	530..630	CDD:238020	24/129 (19%)
		fn3	725..805	CDD:394996	29/132 (22%)
		R-PTPc-O	951..1195	CDD:350462	92/241 (38%)
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020	23/119 (19%)
		PTPc	1100..1345	CDD:214550	95/253 (38%)