DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRO and Lar

DIOPT Version :10

Sequence 1:NP_109592.1 Gene:PTPRO / 5800 HGNCID:9678 Length:1216 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1273 Identity:285/1273 - (22%)
Similarity:478/1273 - (37%) Gaps:373/1273 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    26 NATAFHVT----VQDDNNIVVSLEASDVISPASVYVVKITGESKNYF---FEFE-----EFNST- 77
            |:|:.||:    ::.|.|        .:|....::..::..|.|.:.   |:|:     |||.| 
  Fly   724 NSTSIHVSWKPPLEKDRN--------GIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTG 780

Human    78 LPPPVIFKASYHGL-------YYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPET 135
            |.|...:......|       .....:|...|.|..:|:.|:.::.:. |:.|:.:...:|:...
  Fly   781 LQPDTKYSIQVAALTRKGDGDRSAAIVVKTPGGVPVRPTVSLKIMERE-PIVSIELEWERPAQTY 844

Human   136 GVLFEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWLPGMCYSNITFQLVSEATF 200
            |.|      ..|.:       .|..||  ..|.::...|.                 |:..:...
  Fly   845 GEL------RGYRL-------RWGVKD--QALKEEMLSGP-----------------QMTKKRFD 877

Human   201 NKSTLVEY----SGVSHEPKQHRTAPYPPQNISVRIVNLNKNNWEEQSGNFPEESFMRSQDTIGK 261
            |....|||    :|.:|              |.:                        .|:|:  
  Fly   878 NLERGVEYEFRVAGSNH--------------IGI------------------------GQETV-- 902

Human   262 EKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYENNST 326
             |:|...|.||..|..||:.   .|.:.|....:    ||                         
  Fly   903 -KIFQTPEGTPGGPPSNITI---RFQTPDVLCVT----WD------------------------- 934

Human   327 LSETEKSTSGSFSFFPVQMILTWLPPKPPTAFDGFHIHIER----EENFTEYLMVDEEAHEFVAE 387
             ..|.:..:|..:.:.||                ||..|:.    |.|.|....|       ...
  Fly   935 -PPTREHRNGIITRYDVQ----------------FHKKIDHGLGSERNMTLRKAV-------FTN 975

Human   388 LKEPGKYKLSVTTFSSSGS--------CETRKSQSAKSLSFYISPSGE-----WIEELTEKPQHV 439
            |:|..:|...|..::..|:        .||.:......:|.....:.|     |.|.:|.:.:.:
  Fly   976 LEENTEYIFRVRAYTKQGAGPFSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLL 1040

Human   440 SVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQYCTQVNSSKPIIENLVPGAQ 504
            ...:..:.||:       |:.:......|.||     ||..|               .||...||
  Fly  1041 GYKIFYTMTAV-------EDLDDWQTKTVGLT-----ESADL---------------VNLEKFAQ 1078

Human   505 YQVVIYLRKGPLIGPPSDPVTFAIVPTGIK-DLMLYPLGPTAVVLSWTRPY-------------L 555
            |.|.|..|....:|..|:.||..|.|..:. :|..:.:...::.|||:.|.             :
  Fly  1079 YAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIRLTPVNYKISFDAM 1143

Human   556 GVF-------------RKYVVEMFYFNPATMT--SEWTTYYEIAATVSLTASVRIANLLPAWYYN 605
            .||             ::.::...|....|:.  |.:|||     .|:::|       :|: .|:
  Fly  1144 KVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTY-----NVNVSA-------IPS-DYS 1195

Human   606 FR----VTMVTWGDPELSCCDSSTISFITAP---VAPEITSVEYFNSLLYISWTYGDDTTDLSHS 663
            :|    :|:.|.               :.||   |.|:...|.....:|.|.....::...:|| 
  Fly  1196 YRPPTKITVTTQ---------------MAAPQPMVKPDFYGVVNGEEILVILPQASEEYGPISH- 1244

Human   664 RMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSVTACTERGSNTSMLRLVKLEPAPPKS 728
              .:.:||.|.|..:.|...:.:...:|   ||                       :.:|..|.:
  Fly  1245 --YYLVVVPEDKSNLHKIPDQFLTDDLL---PG-----------------------RNKPERPNA 1281

Human   729 LFAVNK-TQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAV---------SSHVVT---I 780
            .:...| .|.|:...: ..|..|.:..|     :::|.:.::...:         ..|:.|   .
  Fly  1282 PYIAAKFPQRSIPFTF-HLGSGDDYHNF-----TNRKLEREKRYRIFVRAVVDTPQKHLYTSSPF 1340

Human   781 SSLLPATAYNCSVTSFSH-DSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIIL 844
            |..|.............| ..|:.|....||....:..|.::.:.:..::||.::...|:.|.::
  Fly  1341 SEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVV 1405

Human   845 RKKHLQ-------------MARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYL 896
            :::...             ||.:.|||...:.         |.:.||..|.          |..:
  Fly  1406 KRRRQPCKTPDQAAVTRPLMAADLGAGPTPSD---------PVDMRRLNFQ----------TPGM 1451

Human   897 LAFYINPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPL 961
            ::   :|             |:.:.:|..:|:.:..:.:.|||.::|.:: .|.......::|..
  Fly  1452 IS---HP-------------PIPISEFANHIERLKSNDNQKFSQEYESIE-PGQQFTWDNSNLEH 1499

Human   962 NRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVL 1026
            |:.||||.|:..||.|||:|.::....|:|||||||..||.....|:||||||.||..|||:|..
  Fly  1500 NKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCW 1564

Human  1027 QQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRI--NYADEM 1089
            :.|:..|||:|:..|:.|:|||.||| |.....||.|.|.:...:|...::.|.|::  ...::.
  Fly  1565 ELKTATIVMMTRLEERTRIKCDQYWP-TRGTETYGQIFVTITETQELATYSIRTFQLCRQGFNDR 1628

Human  1090 QDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQ 1154
            :::....:|||||||||...|  ..|||:...|.......||:|:||||||||||.:|.:|.:|:
  Fly  1629 REIKQLQFTAWPDHGVPDHPA--PFLQFLRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLE 1691

Human  1155 HIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192
            .::..:.:||.|.|:.:|:.|..|||||:||||||..:
  Fly  1692 RMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAI 1729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRONP_109592.1 fn3 435..521 CDD:394996 18/85 (21%)
FN3 530..630 CDD:238020 21/132 (16%)
fn3 725..805 CDD:394996 14/93 (15%)
R-PTPc-O 951..1195 CDD:350462 104/244 (43%)
LarNP_001260594.1 I-set 36..129 CDD:400151
Ig strand B 53..57 CDD:409353
Ig strand C 66..70 CDD:409353
Ig strand E 93..97 CDD:409353
Ig strand F 108..113 CDD:409353
Ig strand G 122..125 CDD:409353
Ig 141..228 CDD:472250
Ig strand B 157..161 CDD:409353
Ig strand C 170..174 CDD:409353
Ig strand E 192..196 CDD:409353
Ig strand F 206..211 CDD:409353
Ig strand G 218..221 CDD:409353
IgI_3_RPTP_IIa_LAR_like 237..319 CDD:409401
Ig strand A 237..239 CDD:409401
Ig strand A' 244..248 CDD:409401
Ig strand B 251..259 CDD:409401
Ig strand C 264..270 CDD:409401
Ig strand C' 272..274 CDD:409401
Ig strand D 277..281 CDD:409401
Ig strand E 286..291 CDD:409401
Ig strand F 298..305 CDD:409401
Ig strand G 309..318 CDD:409401
FN3 322..411 CDD:238020
FN3 <382..747 CDD:442628 7/30 (23%)
FN3 712..810 CDD:238020 19/93 (20%)
FN3 832..898 CDD:214495 18/135 (13%)
FN3 <867..1269 CDD:442628 103/573 (18%)
fn3 914..998 CDD:394996 23/139 (17%)
R-PTPc-LAR-1 1498..1735 CDD:350401 103/235 (44%)
R-PTP-LAR-2 1784..2021 CDD:350402
Blue background indicates that the domain is not in the aligned region.

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