Protein Alignment PTPRO and IA-2

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Alignment Length: 1008
• Identity: 218/1008 - (21%)
• Similarity: 355/1008 - (35%)
• Gaps: 305/1008 - (30%)

Human   292 ETTSQPYWWDSASAAPESEDEFVSVLPMEYENNSTLSETEKSTSGSFSFFPVQMILTWLPPKPPT 356
            |...|||....| |.|.:.|:..::  :|.:....|.|.::....     ||     ::||
  Fly   409 EPDPQPYQRKPA-AQPNAMDQLEAI--VEQQQQRELKEQQEQAKA-----PV-----YVPP---- 456

Human   357 AFDGFHIHIEREENFTEYLMVDEEAHEFVAELKEPGKYKLSVTTF------SSSGSCETRKSQSA 415
                                  ||.:| .:||..|..:    ..|      |..|..|..:.:..
  Fly   457 ----------------------EEVNE-SSELYFPDNF----APFKRARGRSRGGLAEEVEDEQP 494

Human   416 KSLSFYISPSGEWIEELTEKP----QHVSVHVLSSTTALMSWTSSQ----ENYNSTIVSVVSLTC 472
            |. ||:...:||  :.|.::|    :||...| .:|..|:....:.    :.|:      |||..
  Fly   495 KR-SFFRELAGE--QGLVQEPPLRFRHVETEV-DATPELVKRRPASFKQLDPYD------VSLQQ 549

Human   473 QKQKESQRLEKQYCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPVT---FAIVPTGIK 534
            |:......|.:...|.:.....:..|..|.......:|...|.|:.|..:..|   .|..|..:|
  Fly   550 QEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVK 614

Human   535 DLMLYPLGPTAVVLSWTR----------PYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSL 589
            ..:|      |.:|.:.|          |.||            .|:..::|.:...|   |...
  Fly   615 QSLL------ANMLGFARHERLDVKKPGPLLG------------PPSLGSAELSNQLE---TEKA 658

Human   590 TASVRIAN--LLPAWYYNFRVTMVTWGDPELSCCDSSTI---SFITAPVAPEITSVEYFNSLLYI 649
            .......|  :|||...         |:.|........:   .......||.....||.:  :::
  Fly   659 HKQKGHGNKEVLPAHIK---------GNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVH--VFV 712

Human   650 -----SWTYGD----DTTDLSHSR-MLHWMVVAEGKKKIK-KSVTRNVMTAILSLPPGDIYNLSV 703
                 ||..|.    :...:.|.: ...::.|.:.:...: .|......||      ||:   :.
  Fly   713 KNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTA------GDV---AR 768

Human   704 TACTERGSNTSMLRLVKLEPAPPKSLFAVNKTQTSVTLLWVEEGVADFFEVFCQQVGSSQKTKLQ 768
            |....||        ||            |..|..|....:..||.|..:            .||
  Fly   769 TINENRG--------VK------------NNIQRRVGFYVLHAGVGDVIK------------DLQ 801

Human   769 EPVAVSSHVVTISSLLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNV--VVISVLAILST 831
            :|...||.:                                  .:.|..|:|  ::..:.|....
  Fly   802 DPSVSSSRI----------------------------------ELAEQGPDVTHIMAYMFAGAGA 832

Human   832 LLIGLLLVTLIILRKKH-----------------------------LQMARECGAG--------- 858
            ..:.::.||||:: |:|                             .:||.:.|.|
  Fly   833 AAVIVIFVTLILI-KRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAG 896

Human   859 ---------TFVNFASLERDGKLPYNWRRSIFAFLTLLPSC----LWTDYLLAFYINPWSKNGLK 910
                     ..:...|.|.:|:.|.:  ||..:..:..|:.    :.|.:::..|:....:|
  Fly   897 GGSNEPAPSGRITSLSKENEGRPPSS--RSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRN--- 956

Human   911 KRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCKNRYTNILPYD 975
            |.:|..     :::|..:..|:.|..:                  ||..|.....||....||||
  Fly   957 KGRLQR-----EWEALCRYEAEPSARE------------------AASQPQCAGLNRPGAPLPYD 998

Human   976 FSRVRLVSMNEEEGADYINANYIPGYNSPQ--EYIATQGPLPETRNDFWKMVLQQKSQIIVMLTQ 1038
            .|||.|..:...||.||:||:.|..:: |:  .|:|.|||||.|...||:|:.:|.:.:||.|.:
  Fly   999 HSRVVLNHLANAEGLDYVNASTITDHD-PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR 1062

Human  1039 CNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQ-DDWACRHFRIN--YADEMQDVMHFNYTAW 1100
            ..|...|.|..||| .|....|....|.::||... ||:..|.|.:.  ...|.:.|..|::.:|
  Fly  1063 LQENGEVACARYWP-EEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSW 1126

Human  1101 PDHGVPTANAAESILQFVHMVRQQATKS-KG----PMIIHCSAGVGRTGTFIALDRLLQHI-RDH 1159
            |..|||.  .|:::|.|    |::..|| :|    |:::|.|||.||||.:|.||.:|:.: :..
  Fly  1127 PHMGVPA--QAKALLDF----RRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGA 1185

Human  1160 EFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192
            ..:||...:..:|..|..:|.|.:|:.|:...|
  Fly  1186 REIDIAATLEHLRDQRAGVVATRQQFEFVLMAV 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996	19/93 (20%)
		FN3	530..630	CDD:238020	19/114 (17%)
		fn3	725..805	CDD:394996	11/79 (14%)
		R-PTPc-O	951..1195	CDD:350462	88/253 (35%)
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	22/120 (18%)
		PTP_DSP_cys	942..1225	CDD:475123	96/311 (31%)