Protein Alignment PTPRO and Ptpmeg2

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_572576.1
• Gene: Ptpmeg2 / 31907
• FlyBaseID: FBgn0028341
• Length: 827
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 147/507 - (28%)
• Similarity: 225/507 - (44%)
• Gaps: 111/507 - (21%)

Human   728 SLFAVNKTQT--SVTLLWVEEGVADFFEVFCQQVGSSQKTKLQEPVAVSSHVVTISS-LLPATAY 789
            ::.:.|.|:|  :.|...:...|        .|:|.:..|           |||:|: :.||.:.
  Fly   358 AIVSTNGTETEAATTAATIISAV--------HQLGDNNTT-----------VVTVSNGVGPAGSA 403

Human   790 NCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIGLLLVTLIILRKKHLQMAR- 853
            :...|:             .::..||.|.|                   :|:..|...|.|.|.
  Fly   404 SGGATT-------------AASAATEPNEN-------------------ITINGLSPSHRQAANN 436

Human   854 ----ECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSC--------------LWTDYLLAFY 900
                ...|.|..|...|...|....|   |.....|.....              .|::
  Fly   437 SSSSSSSAATVANPLKLNTSGSADNN---STITNATTAAGAAGAAAGTTTNGGGEFWSE------ 492

Human   901 INP-------WSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAAD 958
             ||       :|.:.....:..:|..:|.....:|...:....|   ::.:::....:.....|.
  Fly   493 -NPPSSASSGFSDDDSLAGQEGDPKPIDQIVQMVKQRGRHGLIK---EYADIRNRAPEGTFLHAR 553

Human   959 LPLNRCKNRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWK 1023
            :..|..|||||::|.||.|||.|...:.:|.:||||||::.||.....||:||||||:|..|||:
  Fly   554 MRANLTKNRYTDVLCYDHSRVVLAHEDGDEPSDYINANFVDGYKQKNAYISTQGPLPKTSQDFWR 618

Human  1024 MVLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEE-PIAYGDITVEMISEEEQDDW--ACRHFRINY 1085
            |:.:|...:|||.|:..|:.||||..||..||| .:.:||..|..||.|..:|:  |....|...
  Fly   619 MIWEQHCLVIVMTTRVMERGRVKCGQYWEPTEESSLEFGDYHVRTISVECNEDYMVASLELRNIK 683

Human  1086 ADEMQDVMHFNYTAWPDHGVPTANAAESILQFVHMVRQ-QATKSKG------------PMIIHCS 1137
            .||:::|.|:.:|:|||:|||  ::|.::|.|:..||: ||...:|            |:::|||
  Fly   684 TDEIRNVSHWQFTSWPDYGVP--SSAMAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCS 746

Human  1138 AGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIH 1189
            ||:|||||||.||..:..:.|....||.|.|.::||.|...:|..:||:|.|
  Fly   747 AGIGRTGTFITLDICISRLEDVGTADIRGTVEKIRSQRAYSIQMPDQYVFCH 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996
		FN3	530..630	CDD:238020
		fn3	725..805	CDD:394996	15/79 (19%)
		R-PTPc-O	951..1195	CDD:350462	107/255 (42%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:469559
		PTPc-N9	529..799	CDD:350391	108/275 (39%)