Protein Alignment PTPRO and Ptp4E

DIOPT Version :10

• Sequence 1: NP_109592.1
• Gene: PTPRO / 5800
• HGNCID: 9678
• Length: 1216
• Species: Homo sapiens
• Sequence 2: NP_525076.2
• Gene: Ptp4E / 31425
• FlyBaseID: FBgn0004368
• Length: 1767
• Species: Drosophila melanogaster
• Alignment Length: 1332
• Identity: 333/1332 - (25%)
• Similarity: 534/1332 - (40%)
• Gaps: 370/1332 - (27%)

Human    36 DD--NNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKASYH--------- 89
            ||  |.:.:|.|.::            ||...:|...:.|..:....|..|..:..
  Fly   445 DDRSNALHISWEPAE------------TGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTE 497

Human    90 --------GLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVL-------- 138
                    |..|:|.:..::..|.:..| .||..|:|    :..:.....|.:.|::
  Fly   498 YTLDSLLAGRRYLIAVQALSKGVASNAS-DITRYTRP----AAPLIQELRSIDQGLMLSWRSDVN 557

Human   139 -----FEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWL-PGMCYSNITFQLVSE 197
                 :|:||.....            ::.|||...:    .::..|:| ||..| .:....:|.
  Fly   558 SRQDRYEVHYQRNGT------------REERTMATNE----TSLTIHYLHPGSGY-EVKVHAISH 605

Human   198 ATFNKSTLVEYSGVSHEPKQHRTA--PYPPQNISVRIV--NLNKNNWEEQSGNFPEESFMRSQDT 258
                        ||..||..:..|  |.||||::::.|  ||...:|:...|:...|..:|
  Fly   606 ------------GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVR---- 654

Human   259 IGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYEN 323
                                            |.|.:.|  |...|...|:|   ..:..|.| .
  Fly   655 --------------------------------YRTDASP--WQRISGLHENE---ARIKDMHY-G 681

Human   324 NSTLSETEKSTSGSFSFFPVQMILTWLPPKPPT----AFDGFHIHIE--REENFTEYLMV----- 377
            ...|.:....:.|..|..|:::.:| :||:|.:    ..|..::.:|  |.:...::..:
  Fly   682 ERYLVQVNTVSFGVESPHPLELNVT-MPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPT 745

Human   378 -DEEAHEF--VAELKE--------------PGK-YKLSVTTFSSSG--SCETRKSQSAKSL---S 419
             :|:..||  |.:|::              ||: |:..|.. ||:|  |..|..|.....|   .
  Fly   746 DEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQA-SSNGIRSGTTHLSTRTMPLIQSD 809

Human   420 FYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQ 484
            .:|:.:|.      |:.|        ..|..:|:|.:..:.....:...|:.....|:.::|...
  Fly   810 VFIANAGH------EQGQ--------DETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLAND 860

Human   485 YCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV--TFAIVPTGIKDLMLYPLGPTAVV 547
                 ...|.....|.||..|.|.::...|   |..|.||  .:.:.|..|.||....:....:.
  Fly   861 -----TERKLSFSGLTPGKLYNVTVWTVSG---GVASLPVQRLYRLHPLPISDLKAIQVAAREIT 917

Human   548 LSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT 612
            |.||.| .|.:..:  |:.|.:......      ::...|:....:.:..|.|  |:|:..|:|.
  Fly   918 LHWTAP-AGEYTDF--ELQYLSADEEAP------QLLQNVTKNTEITLQGLRP--YHNYTFTVVV 971

Human   613 ---------WGDPELSCC--DSSTIS----FITAP-----------VAP-EIT------------ 638
                     :.|..:|..  .|:.||    .:|||           |.| |:|
  Fly   972 RSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHG 1036

Human   639 SVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSV 703
            .::||.    |:....||..|:|.....  :...:||              |..|.||:.|...:
  Fly  1037 PIDYFR----ITCQNADDAADVSSYEFP--VNATQGK--------------IDGLVPGNHYIFRI 1081

Human   704 TACTERGSNTSMLRL----VKLEPAPPKSLFAVNKTQTSVTL-LWVEEG--------VADFFEVF 755
            .|.:..|.......:    :...|.|..|:..:..::||.|: :...:|        |..:..:.
  Fly  1082 QAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIII 1146

Human   756 CQQVG------------------------------------SSQKTKLQEPVAVSSHVVTISS-- 782
            .:.||                                    .|:|:.|:     :.| .||.:
  Fly  1147 AEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLE-----AEH-FTIGTAN 1205

Human   783 ------------LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIG 835
                        |...|.|...:.:|:.:.....| :..|.:.||.:..|:|.:.::  :.||:.
  Fly  1206 CDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT-VYSSPITTERSDTVIVAATVS--AVLLVA 1267

Human   836 LLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY 900
            ::||  ::..:...|:.|...     ..|.::.:              |..||.         .|
  Fly  1268 MVLV--VVYCQHRCQLIRRAS-----KLARMQDE--------------LAALPE---------GY 1302

Human   901 INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCK 965
            |.|           ..||.:.||..:.:.|:.|||::||.:|||||.:|.|.....|:||.||.|
  Fly  1303 ITP-----------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPK 1356

Human   966 NRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 1030
            ||:|||||||.||.:|..:::::|:|||||||:||:|||:|:|.|||||..||.:||:|..:..|
  Fly  1357 NRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNS 1421

Human  1031 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHF 1095
            :.|||||:|.||.|.|||.|||.....:.||||.|::|.:....||:...|.::...|.:.:.||
  Fly  1422 RAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHF 1486

Human  1096 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE 1160
            ::|.|||.|||  ...:|:::||...|........|:|:||||||||:||||||||:||||...:
  Fly  1487 HFTTWPDFGVP--EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSD 1549

Human  1161 FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192
            :|||.|:|..||..|:.|||||:||:.||||:
  Fly  1550 YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRO	NP_109592.1	fn3	435..521	CDD:394996	15/85 (18%)
		FN3	530..630	CDD:238020	23/114 (20%)
		fn3	725..805	CDD:394996	19/138 (14%)
		R-PTPc-O	951..1195	CDD:350462	124/242 (51%)
Ptp4E	NP_525076.2	FN3	<94..>334	CDD:442628
		fn3	247..328	CDD:394996
		FN3	319..>749	CDD:442628	71/392 (18%)
		fn3	708..796	CDD:394996	19/88 (22%)
		fn3	902..978	CDD:394996	17/86 (20%)
		fn3	1013..1092	CDD:394996	20/98 (20%)
		PTP_tm	1127..1247	CDD:465889	16/126 (13%)
		R3-PTPc	1358..1579	CDD:350396	113/222 (51%)