DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRO and Ptp4E

DIOPT Version :9

Sequence 1:NP_109592.1 Gene:PTPRO / 5800 HGNCID:9678 Length:1216 Species:Homo sapiens
Sequence 2:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1332 Identity:332/1332 - (24%)
Similarity:535/1332 - (40%) Gaps:370/1332 - (27%)


- Green bases have known domain annotations that are detailed below.


Human    36 DD--NNIVVSLEASDVISPASVYVVKITGESKNYFFEFEEFNSTLPPPVIFKASYH--------- 89
            ||  |.:.:|.|.::            ||...:|...:.|..:....|..|..:..         
  Fly   445 DDRSNALHISWEPAE------------TGRQDSYRISYHEQTNASEVPAPFPVAAESQITTNLTE 497

Human    90 --------GLYYIITLVVVNGNVVTKPSRSITVLTKPLPVTSVSIYDYKPSPETGVL-------- 138
                    |..|:|.:..::..|.:..| .||..|:|    :..:.....|.:.|::        
  Fly   498 YTLDSLLAGRRYLIAVQALSKGVASNAS-DITRYTRP----AAPLIQELRSIDQGLMLSWRSDVN 557

Human   139 -----FEIHYPEKYNVFTRVNISYWEGKDFRTMLYKDFFKGKTVFNHWL-PGMCYSNITFQLVSE 197
                 :|:||.....            ::.|||...:    .::..|:| ||..| .:....:|.
  Fly   558 SRQDRYEVHYQRNGT------------REERTMATNE----TSLTIHYLHPGSGY-EVKVHAISH 605

Human   198 ATFNKSTLVEYSGVSHEPKQHRTA--PYPPQNISVRIV--NLNKNNWEEQSGNFPEESFMRSQDT 258
                        ||..||..:..|  |.||||::::.|  ||...:|:...|:...|..:|    
  Fly   606 ------------GVRSEPHSYFQAVFPKPPQNLTLQTVHTNLVVLHWQAPEGSDFSEYVVR---- 654

Human   259 IGKEKLFHFTEETPEIPSGNISSGWPDFNSSDYETTSQPYWWDSASAAPESEDEFVSVLPMEYEN 323
                                            |.|.:.|  |...|...|:|   ..:..|.| .
  Fly   655 --------------------------------YRTDASP--WQRISGLHENE---ARIKDMHY-G 681

Human   324 NSTLSETEKSTSGSFSFFPVQMILTWLPPKPPT----AFDGFHIHIE--REENFTEYLMV----- 377
            ...|.:....:.|..|..|:::.:| :||:|.:    ..|..::.:|  |.:...::..:     
  Fly   682 ERYLVQVNTVSFGVESPHPLELNVT-MPPQPVSNVVPLVDSRNLTLEWPRPDGHVDFYTLKWWPT 745

Human   378 -DEEAHEF--VAELKE--------------PGK-YKLSVTTFSS---SGS--CETRKSQSAKSLS 419
             :|:..||  |.:|::              ||: |:..|...|:   ||:  ..||.....:| .
  Fly   746 DEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRFEVQASSNGIRSGTTHLSTRTMPLIQS-D 809

Human   420 FYISPSGEWIEELTEKPQHVSVHVLSSTTALMSWTSSQENYNSTIVSVVSLTCQKQKESQRLEKQ 484
            .:|:.:|.      |:.|        ..|..:|:|.:..:.....:...|:.....|:.::|...
  Fly   810 VFIANAGH------EQGQ--------DETITLSYTPTPADSTRFDIYRFSMGDPTIKDKEKLAND 860

Human   485 YCTQVNSSKPIIENLVPGAQYQVVIYLRKGPLIGPPSDPV--TFAIVPTGIKDLMLYPLGPTAVV 547
                 ...|.....|.||..|.|.::...|   |..|.||  .:.:.|..|.||....:....:.
  Fly   861 -----TERKLSFSGLTPGKLYNVTVWTVSG---GVASLPVQRLYRLHPLPISDLKAIQVAAREIT 917

Human   548 LSWTRPYLGVFRKYVVEMFYFNPATMTSEWTTYYEIAATVSLTASVRIANLLPAWYYNFRVTMVT 612
            |.||.| .|.:..:  |:.|.:......      ::...|:....:.:..|.|  |:|:..|:|.
  Fly   918 LHWTAP-AGEYTDF--ELQYLSADEEAP------QLLQNVTKNTEITLQGLRP--YHNYTFTVVV 971

Human   613 ---------WGDPELSCC--DSSTIS----FITAP-----------VAP-EIT------------ 638
                     :.|..:|..  .|:.||    .:|||           |.| |:|            
  Fly   972 RSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPGKVDYFQPSDVQPGEVTFEWSLEPAEQHG 1036

Human   639 SVEYFNSLLYISWTYGDDTTDLSHSRMLHWMVVAEGKKKIKKSVTRNVMTAILSLPPGDIYNLSV 703
            .::||.    |:....||..|:|.....  :...:||              |..|.||:.|...:
  Fly  1037 PIDYFR----ITCQNADDAADVSSYEFP--VNATQGK--------------IDGLVPGNHYIFRI 1081

Human   704 TACTERGSNTSMLRL----VKLEPAPPKSLFAVNKTQTSVTL-LWVEEG--------VADFFEVF 755
            .|.:..|.......:    :...|.|..|:..:..::||.|: :...:|        |..:..:.
  Fly  1082 QAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFSNAHGMVRSYTIII 1146

Human   756 CQQVG------------------------------------SSQKTKLQEPVAVSSHVVTISS-- 782
            .:.||                                    .|:|:.|:     :.| .||.:  
  Fly  1147 AEDVGKNASGLEMPSWQDVQAYTVWLPYQAIEPYNPFLTSNGSRKSSLE-----AEH-FTIGTAN 1205

Human   783 ------------LLPATAYNCSVTSFSHDSPSVPTFIAVSTMVTEMNPNVVVISVLAILSTLLIG 835
                        |...|.|...:.:|:.:.....| :..|.:.||.:..|:|.:.::  :.||:.
  Fly  1206 CDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDT-VYSSPITTERSDTVIVAATVS--AVLLVA 1267

Human   836 LLLVTLIILRKKHLQMARECGAGTFVNFASLERDGKLPYNWRRSIFAFLTLLPSCLWTDYLLAFY 900
            ::||  ::..:...|:.|...     ..|.::.:              |..||.         .|
  Fly  1268 MVLV--VVYCQHRCQLIRRAS-----KLARMQDE--------------LAALPE---------GY 1302

Human   901 INPWSKNGLKKRKLTNPVQLDDFDAYIKDMAKDSDYKFSLQFEELKLIGLDIPHFAADLPLNRCK 965
            |.|           ..||.:.||..:.:.|:.|||::||.:|||||.:|.|.....|:||.||.|
  Fly  1303 ITP-----------NRPVHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPK 1356

Human   966 NRYTNILPYDFSRVRLVSMNEEEGADYINANYIPGYNSPQEYIATQGPLPETRNDFWKMVLQQKS 1030
            ||:|||||||.||.:|..:::::|:|||||||:||:|||:|:|.|||||..||.:||:|..:..|
  Fly  1357 NRFTNILPYDHSRFKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNS 1421

Human  1031 QIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHF 1095
            :.|||||:|.||.|.|||.|||.....:.||||.|::|.:....||:...|.::...|.:.:.||
  Fly  1422 RAIVMLTRCFEKGREKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVSRNCESRIMRHF 1486

Human  1096 NYTAWPDHGVPTANAAESILQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHE 1160
            ::|.|||.|||  ...:|:::||...|........|:|:||||||||:||||||||:||||...:
  Fly  1487 HFTTWPDFGVP--EPPQSLVRFVRAFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSD 1549

Human  1161 FVDILGLVSEMRSYRMSMVQTEEQYIFIHQCV 1192
            :|||.|:|..||..|:.|||||:||:.||||:
  Fly  1550 YVDIFGIVFAMRKERVFMVQTEQQYVCIHQCL 1581

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRONP_109592.1 fn3 435..521 CDD:306538 15/85 (18%)
FN3 530..630 CDD:238020 23/114 (20%)
fn3 725..805 CDD:306538 19/138 (14%)
PTPc 965..1193 CDD:238006 118/228 (52%)
Substrate binding. /evidence=ECO:0000250 1136..1142 5/5 (100%)
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020
fn3 247..328 CDD:278470
fn3 343..417 CDD:278470
fn3 443..525 CDD:278470 15/91 (16%)
FN3 548..611 CDD:238020 14/91 (15%)
FN3 620..706 CDD:238020 25/127 (20%)
fn3 708..796 CDD:278470 18/87 (21%)
fn3 824..886 CDD:278470 13/69 (19%)
fn3 902..978 CDD:278470 17/86 (20%)
fn3 1013..1092 CDD:278470 20/98 (20%)
UP_III_II 1106..>1248 CDD:297589 21/148 (14%)
PTPc 1329..1582 CDD:214550 132/255 (52%)
PTPc 1355..1582 CDD:238006 118/229 (52%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165146162
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0791
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.710

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