Protein Alignment ACTA1 and ACT1

DIOPT Version :10

• Sequence 1: NP_001091.1
• Gene: ACTA1 / 58
• HGNCID: 129
• Length: 377
• Species: Homo sapiens
• Sequence 2: NP_116614.1
• Gene: ACT1 / 850504
• SGDID: S000001855
• Length: 375
• Species: Saccharomyces cerevisiae
• Alignment Length: 374
• Identity: 325/374 - (86%)
• Similarity: 353/374 - (94%)
• Gaps: 0/374 - (0%)

Human     4 EDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILT 68
            :.|..|||.|||||:.|||||||||||||||||||||||||:|||||||||||||||||||||||
Yeast     2 DSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILT 66

Human    69 LKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPA 133
            |:|||||||:||||||||||||||||||||||||||.||||||:|||:|||||||||||||||||
Yeast    67 LRYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMFETFNVPA 131

Human   134 MYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTER 198
            .||:||||||||:|||||||||||||||||.||||.|::|||||:|:|||||||||||||||:||
Yeast   132 FYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAILRIDLAGRDLTDYLMKILSER 196

Human   199 GYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETL 263
            ||||.|||||||||||||||||||||||.||.|||.|||:||||||||||||||||||||.||.|
Yeast   197 GYSFSTTAEREIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIGNERFRAPEAL 261

Human   264 FQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMK 328
            |.||.:|:|||||.:||||||||||:|:||:||.|.||||||||:||||:||||||||||||:||
Yeast   262 FHPSVLGLESAGIDQTTYNSIMKCDVDVRKELYGNIVMSGGTTMFPGIAERMQKEITALAPSSMK 326

Human   329 IKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF 377
            :||||||||||||||||||||||:|||||||:||||||:||||||.|||
Yeast   327 VKIIAPPERKYSVWIGGSILASLTTFQQMWISKQEYDESGPSIVHHKCF 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ACTA1	NP_001091.1	ASKHA_NBD_actin	8..372	CDD:466823	318/363 (88%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	112..125		10/12 (83%)
		Interaction with alpha-actinin. /evidence=ECO:0000250|UniProtKB:P68135	360..372		9/11 (82%)
ACT1	NP_116614.1	ASKHA_NBD_actin	6..370	CDD:466823	318/363 (88%)