DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PTPRM and Y71G12B.31

DIOPT Version :9

Sequence 1:	XP_011524010.1	Gene:	PTPRM / 5797	HGNCID:	9675	Length:	1507	Species:	Homo sapiens
Sequence 2:	NP_001293450.1	Gene:	Y71G12B.31 / 3565511	WormBaseID:	WBGene00044348	Length:	423	Species:	Caenorhabditis elegans

Alignment Length:	378	Identity:	109/378 - (28%)
Similarity:	163/378 - (43%)	Gaps:	85/378 - (22%)

- Green bases have known domain annotations that are detailed below.

Human   900 KKREPADVPYQT-----------------GQLH-------PAIRVADLLQHITQMKC--AEGYGF 938
            |..|||..|.:.                 .|::       ||.:..|.|:..|...|  ......
Worm    53 KVEEPAPPPVEVTTKEIAVIAAAAAADGKNQINGFQKISTPAAKRPDKLRIDTNKVCPAQSAIAM 117

Human   939 KEEY--ESFFEGQSAPWDSAKKDENRMK------------------------------NRYGNII 971
            :.:|  :||....:      |:..||.:                              |||.:|:
Worm   118 ETDYSADSFLASMT------KESTNRRRLLQDEFLVLSRTEARRLTRSTDRATRHAAANRYSDIV 176

Human   972 AYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPM-------QETIYDFWRMVWHENT 1029
            .|||:.|.|.|      .||||.:::.|......:||||||:       :||:.|||||:...:.
Worm   177 PYDHTLVELDT------GDYINASFVQGESDATRWIATQGPIDSGECIGKETVSDFWRMIVQYDV 235

Human  1030 ASIIMVTNLVEVGRVKCCKYWPD---DTEIYKDIKVTLIETELLAE-YVIRTFAVEKGGAGGEAN 1090
            |.|:|:....|....||.:|||.   .||.|.::.|.|: .||..: :|.|.|.|....:...:.
Worm   236 ACIVMLGQHQEDFVQKCGEYWPSAMGKTERYGEVDVKLV-CELEEKTWVHREFDVSPTSSYSSST 299

Human  1091 CSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAG 1155
            .|..:..:.|....:: :.|:.:..|.|.|........|.|:.||:.:...|  |:|||||||.|
Worm   300 KSSRKSRASRQQSHMK-VSQWQYKEWKDTGGAPRIANFLEFLLQVRGRQYTS--PIVVHCSAGIG 361

Human  1156 RTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILE 1208
            |||.||..|.::...|.||::||::.|...|.:|.:||.|.:||..|:|.|.|
Worm   362 RTGVFICTDNVISRFESEGIIDIFSEVNRSRQQRPSMVYTVKQYECIYDIIGE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRM	XP_011524010.1	MAM	22..182	CDD:214533
		MAM	27..182	CDD:99706
		IG_like	192..278	CDD:214653
		ig	192..274	CDD:278476
		FN3	282..361	CDD:214495
		FN3	383..477	CDD:238020
		FN3	499..581	CDD:238020
		PTPc	937..1208	CDD:214550	96/313 (31%)
		PTPc	964..1208	CDD:238006	90/284 (32%)
		PTPc	1240..1502	CDD:214550
		PTPc	1270..1502	CDD:238006
Y71G12B.31	NP_001293450.1	PTPc	170..414	CDD:238006	90/253 (36%)
Y71G12B.31	NP_001293450.1	Y_phosphatase	170..412	CDD:278528	89/251 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4228
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810