DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRM and Dscam1

DIOPT Version :9

Sequence 1:XP_011524010.1 Gene:PTPRM / 5797 HGNCID:9675 Length:1507 Species:Homo sapiens
Sequence 2:NP_001246162.1 Gene:Dscam1 / 35652 FlyBaseID:FBgn0033159 Length:2038 Species:Drosophila melanogaster


Alignment Length:1448 Identity:275/1448 - (18%)
Similarity:428/1448 - (29%) Gaps:492/1448 - (33%)


- Green bases have known domain annotations that are detailed below.


Human    30 DEPYSTCGYSQSEGDDFNWEQV------NTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQ 88
            |.|.......:....|:.::||      |.:::.||...:||.|                   |.
  Fly   649 DRPIKVHWSFERSAGDYGFDQVQPQMRTNRISEKTSMISIPSAS-------------------PA 694

Human    89 LKENDTHCIDFH------YFVSSKSNSPPGLL--------------NVYVKVNNGPLGNPIWNIS 133
            ....|| ||..:      |.|....|.||..:              .|..|.:..|         
  Fly   695 HTGRDT-CIASNKAGTTTYSVDLTVNVPPRWILEPTDKAFAQGSDAKVECKADGFP--------- 749

Human   134 GDPTRTWNRAELAISTFWPNFYQVI--------------FEVITSGHQGYLAIDEVKVLGHPCTR 184
             .|..||.:|  ...|  |..|:.:              .:.|...::||...:.:..:|...:.
  Fly   750 -KPQVTWKKA--VGDT--PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSA 809

Human   185 T--------PHFL-RIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVT---- 236
            .        |.|. :::|.....|:.|..||.|.|....| .||... ::|..|..:.:.|    
  Fly   810 VIMISVQAPPEFTEKLRNQTARRGEPAVLQCEAKGEKPIG-ILWNMN-NMRLDPKNDNRYTIREE 872

Human   237 -SSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWI 300
             .|...::|.::..|.:.|:..:.|:.....|...::...:|.:.|.:|.|...|...|.:   :
  Fly   873 ILSTGVMSSLSIKRTERSDSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---V 934

Human   301 QLN-ANSINGDGPIVAREVEYCTASGSWN--DR--QPVDSTSYKIGHLDPDTEYEISVLLTRPGE 360
            ||: |...:|:.|:....:|:..:..||:  ||  .|..:|..::..|.|.|.|.|.::    .|
  Fly   935 QLSWAQPYDGNSPLDRYIIEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV----AE 995

Human   361 G--GTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP--------------FGYNVTR 409
            .  ||.....|:...|....|...|:.::|..|....:.:.|:|              .||.::.
  Fly   996 NAIGTSQSSEAVTIITAEEAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSN 1060

Human   410 CHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHT--ITNLSPYTNVSVKLILMN-----PEGR 467
            .:|              ..|.|.:::.||.. .:|.  :.||..||..||.:...|     |...
  Fly  1061 TNS--------------SYVFETINFITEEG-KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSE 1110

Human   468 KESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREP--TQTYGVITLYEITYKAVSSFDPEI 530
            :|.|    .|.|..|...|:::...:...:.|.:.|..|  ....|||..|::.|.      |..
  Fly  1111 EEKQ----FTAEGTPSQPPSDTACTTLTSQTIRVGWVSPPLESANGVIKTYKVVYA------PSD 1165

Human   531 DLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAY---E 592
            :..:::.|..|....:..:..||...|.|:..:.|:||.|.|            ..|:|.:   |
  Fly  1166 EWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG------------VRSVPIHCQTE 1218

Human   593 LETPLNQTDNTVTVM---------LKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIH 648
            .:.|...||....||         ..||...|. ::.|.:..:.|......||.:      || |
  Fly  1219 PDVPEAPTDVKALVMGNAAILVSWRPPAQPNGI-ITQYTVYSKAEGAETETKTQK------VP-H 1275

Human   649 FQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGE-- 711
            :|            ..|.|..|:..:|:.         :|.|              ||...||  
  Fly  1276 YQ------------MSFEATELEKNKPYE---------FWVT--------------ASTTIGEGQ 1305

Human   712 -----TKIDCVQVATKAAIIVTQLTTPYIRIAPAAGDGQLTGAATPKPVPEPEKQTDHTVKIAGV 771
                 ..:...||..|.|......|..:      ..|.::...|...|.||      .|.||.||
  Fly  1306 QSKSIVAMPSDQVPAKIASFDDTFTATF------KEDAKMPCLAVGAPQPE------ITWKIKGV 1358

Human   772 IAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDT 836
                                          ..|....|.|:   .|.|...:..|..:|..:   
  Fly  1359 ------------------------------EFSANDRMRVL---PDGSLLIKSVNRQDAGDY--- 1387

Human   837 HNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILVPINDETHTMASDTSSLVQSHTYKK 901
                                 |....||...|......|::......|...|.|::...:...|.
  Fly  1388 ---------------------SCHAENSIAKDSITHKLIVLAPPQSPHVTLSATTTDALTVKLKP 1431

Human   902 REPADVPYQTGQLH----------PAIRVADLLQHITQMKCAEGY-----GFKE----------- 940
            .|....|.....||          ..:.|.....:|..:.|...|     ||..           
  Fly  1432 HEGDTAPLHGYTLHYKPEFGEWETSEVSVDSQKHNIEGLLCGSRYQVYATGFNNIGAGEASDILN 1496

Human   941 -----------EYESFFEGQS-------APW------------DSAKKDE---NRMKNRY---GN 969
                       |...|.|..|       ..|            :|.|:|:   |::.|..   .|
  Fly  1497 TRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHFVVESKKRDQIEWNQISNNVKPDNN 1561

Human   970 IIAYD-------HSRVRLQTIEGDTNSDY------INGNYI----DGYHRPNHYIATQGPMQETI 1017
            .:..|       :.|:......|.|.::|      :.|..|    ||....|.:...:.|.    
  Fly  1562 YVVLDLEPATWYNLRITAHNSAGFTVAEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPA---- 1622

Human  1018 YDFWRMVWHENTASIIMVTN--LVEVGRVKCC----KYWPDD-----TEIYKDI--------KVT 1063
               |...|.:....:.::..  :|.||....|    :...||     .::|.|:        ..|
  Fly  1623 ---WMPEWLDLNFMVPLIATVVVVAVGICVVCVALSRRRADDMRGGQKDVYYDVVYNQTMGPGAT 1684

Human  1064 L------IETELLAEYV--------------IRTFAVEKGGAGG----EANCSPSRE-------- 1096
            |      :..||  .|:              ..|....|.|.||    .:...|.|.        
  Fly  1685 LDKRRPDLRDEL--GYIAPPNRKLPPVPGSNYNTCDRIKRGRGGLRSNHSTWDPRRNPNLYEELK 1747

Human  1097 ---VSQRGVH-------------------EIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKS 1139
               |...|.|                   ||.....||..|:.:...|..|.....|..|.....
  Fly  1748 APPVPMHGNHYGHAHGNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFPHQNGHAG 1812

Human  1140 P---------PSAGPLVVHCSAGAGRTGCFIVIDIMLDMAER-------EGVVDIY--------- 1179
            |         |...|..||..:|:.          .:..|.|       .|...||         
  Fly  1813 PVPGHAGTMLPPGHPGHVHSRSGSQ----------SMPRANRYQRKNSQGGQSSIYTPAPEYDDP 1867

Human  1180 -NCVRELRSRRVNMVQTE 1196
             ||..|.:.||...|.::
  Fly  1868 ANCAEEDQYRRYTRVNSQ 1885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRMXP_011524010.1 MAM 22..182 CDD:214533 35/191 (18%)
MAM 27..182 CDD:99706 35/191 (18%)
IG_like 192..278 CDD:214653 19/90 (21%)
ig 192..274 CDD:278476 19/86 (22%)
FN3 282..361 CDD:214495 21/83 (25%)
FN3 383..477 CDD:238020 23/114 (20%)
FN3 499..581 CDD:238020 20/83 (24%)
PTPc 937..1208 CDD:214550 75/423 (18%)
PTPc 964..1208 CDD:238006 64/352 (18%)
PTPc 1240..1502 CDD:214550
PTPc 1270..1502 CDD:238006
Dscam1NP_001246162.1 Ig 38..130 CDD:299845
IG 57..133 CDD:214652
IG_like 267..343 CDD:214653
Ig 269..340 CDD:143165
IG_like 353..425 CDD:214653
IGc2 361..413 CDD:197706
I-set 433..527 CDD:254352
IGc2 446..517 CDD:197706
I-set 533..618 CDD:254352
IGc2 544..607 CDD:197706
Ig 641..714 CDD:143165 17/84 (20%)
IGc2 735..804 CDD:197706 13/82 (16%)
I-set 819..914 CDD:254352 21/96 (22%)
Ig 833..921 CDD:299845 20/89 (22%)
FN3 918..1011 CDD:238020 26/99 (26%)
FN3 1018..1116 CDD:238020 23/116 (20%)
FN3 1124..1217 CDD:238020 23/110 (21%)
FN3 1222..1312 CDD:238020 26/132 (20%)
Ig 1339..1406 CDD:299845 20/129 (16%)
FN3 1409..1499 CDD:238020 14/89 (16%)
FN3 1504..1584 CDD:238020 13/79 (16%)
Dscam_C 1890..2008 CDD:289151
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.