DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRM and Lar

DIOPT Version :9

Sequence 1:XP_011524010.1 Gene:PTPRM / 5797 HGNCID:9675 Length:1507 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1729 Identity:488/1729 - (28%)
Similarity:731/1729 - (42%) Gaps:403/1729 - (23%)


- Green bases have known domain annotations that are detailed below.


Human    50 QVNTLTKPT-----SDPWMPSGS------FMLVNASGRPEGQ-RAHLL----LPQLKENDTHCID 98
            ||.||:..|     ..|..|:|.      :...| |.:||.. .:.::    |..:.|...|.| 
  Fly   429 QVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTN-SNQPEASWNSQMVDNSELTTVSELTPHAI- 491

Human    99 FHYFVSSKSNSPPGLLNVYVKVNNGPLGNPI-----WNISGDPT--RTWNRAELAISTFWPN--- 153
              |.|.         :..|..:..||:..|:     ..:...|:  |..:..|.|::..|..   
  Fly   492 --YTVR---------VQAYTSMGAGPMSTPVQVKAQQGVPSQPSNFRATDIGETAVTLQWTKPTH 545

Human   154 ------FYQVIFE--VITSGHQGYLAIDEVKVL-------------------GHPCTRTPHFLRI 191
                  .|::.:.  .....|...::..|...|                   |...|..|..:|.
  Fly   546 SSENIVHYELYWNDTYANQAHHKRISNSEAYTLDGLYPDTLYYIWLAARSQRGEGATTPPIPVRT 610

Human   192 -------QNVEVNAGQFATFQCSAI--------GRTVAGDRLWLQ-GIDVRDAPLKEIKVTSSRR 240
                   :|:...|....|...|.:        ||.:.....::: |.:..:|....:.:||.  
  Fly   611 KQYGAPPRNITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSI-- 673

Human   241 FIASFNVVNTTKRDAGKYRCMI--RTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYL----- 298
                  |::..||.. :|:..:  .|..|.|..::..::..:..|| ..||  .|.||.|     
  Fly   674 ------VLDELKRWT-EYKIWVLAGTSVGDGPRSHPIILRTQEDVP-GDPQ--DVKATPLNSTSI 728

Human   299 ---W---IQLNANSINGDGPIVAREVEYCTASGSWNDR---QPVDSTSYKIGHLDPDTEYEISV- 353
               |   ::.:.|.|.....|.|:|:. ....|..|:.   ..||:..:.:..|.|||:|.|.| 
  Fly   729 HVSWKPPLEKDRNGIIRGYHIHAQELR-DEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVA 792

Human   354 LLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQ----ITIRWEPFGYNVTRCHSYN 414
            .|||.|:|...:   |:..:|....|:|....|:::|   |:    |.:.||...........|.
  Fly   793 ALTRKGDGDRSA---AIVVKTPGGVPVRPTVSLKIME---REPIVSIELEWERPAQTYGELRGYR 851

Human   415 LTVHYCYQVGGQEQ-VREEVSWDTENSHPQHT---ITNLSPYTNVSVKLILMNPEGRKESQELIV 475
            |      :.|.::| ::||:.     |.||.|   ..||........::...|..|..:....|.
  Fly   852 L------RWGVKDQALKEEML-----SGPQMTKKRFDNLERGVEYEFRVAGSNHIGIGQETVKIF 905

Human   476 QTDEDLPGAVPTE-SIQGSTFEEKIFLQWREPTQTY--GVITLYEITYKAVSSFDPEIDLSNQSG 537
            ||.|..||..|:. :|:..| .:.:.:.|..||:.:  |:||.|::      .|..:||      
  Fly   906 QTPEGTPGGPPSNITIRFQT-PDVLCVTWDPPTREHRNGIITRYDV------QFHKKID------ 957

Human   538 RVSKLGNETHF-----LFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPL 597
              ..||:|.:.     :|..|...|.|.|.:||.|.:|.||     |:.|:      ..|.|..:
  Fly   958 --HGLGSERNMTLRKAVFTNLEENTEYIFRVRAYTKQGAGP-----FSDKL------IVETERDM 1009

Human   598 NQ----------TDNTVTVMLKPAHSRGAPVS---VYQIVVEEERPRRTKKTTEILKCYPVPIHF 649
            .:          ::.|..:..:|..|||..:.   .|.:...|:......||..:.         
  Fly  1010 GRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVEDLDDWQTKTVGLT--------- 1065

Human   650 QNASLLN----SQY--YFAAEFPADSLQAAQPFTI-------------GDNKTYNG--YWNTPL- 692
            ::|.|:|    :||  ..||.|.....:.::..|:             .|..|::.  .|:.|: 
  Fly  1066 ESADLVNLEKFAQYAVAIAARFKNGLGRLSEKVTVRIKPEDVPLNLRAHDVSTHSMTLSWSPPIR 1130

Human   693 LPYKSYRIYFQAASRANGETKIDCVQVATKAAII------------VTQLTTPYIRIAPAAGDGQ 745
            |...:|:|.|.|.............|:..|..||            ::..||..:.::....|..
  Fly  1131 LTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTHTINELSPFTTYNVNVSAIPSDYS 1195

Human   746 ---------LTGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKET 801
                     .|..|.|:|:.:|:        ..||:.|..:.||:              .:..|.
  Fly  1196 YRPPTKITVTTQMAAPQPMVKPD--------FYGVVNGEEILVIL--------------PQASEE 1238

Human   802 MSSTRQEMTVMVNSMDKSYAEQ------------GTNCDE----------------AFSFM---- 834
            .........|:|.. |||...:            |.|..|                .|:|.    
  Fly  1239 YGPISHYYLVVVPE-DKSNLHKIPDQFLTDDLLPGRNKPERPNAPYIAAKFPQRSIPFTFHLGSG 1302

Human   835 -DTHNLNGRSVSSPSSFTMKTNT--------LSTSVPNSYY----------------PDPFVPTA 874
             |.||...|.:.....:.:....        |.||.|.|.:                |||..|..
  Fly  1303 DDYHNFTNRKLEREKRYRIFVRAVVDTPQKHLYTSSPFSEFLSLDMREAPPGERPHRPDPNWPAE 1367

Human   875 ILVPIN---DE-----------THTMASDTSSLVQSHTYKKREPADVP----------------- 908
            ..|.:|   ||           ..|....|:.:|.....::|:|...|                 
  Fly  1368 PEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLCVVKRRRQPCKTPDQAAVTRPLMAADLGAG 1432

Human   909 -------------YQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKK 958
                         :|| |.: ||.|.:::...||.::|..:...|.:||||...||...||::..
  Fly  1433 PTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIERLKSNDNQKFSQEYESIEPGQQFTWDNSNL 1497

Human   959 DENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRM 1023
            :.|:.||||.|:.|||||||:|..:||...|||||.||.|||.:.|.|:|||||:|||..|||||
  Fly  1498 EHNKSKNRYANVTAYDHSRVQLPAVEGVVGSDYINANYCDGYRKHNAYVATQGPLQETFVDFWRM 1562

Human  1024 VWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGG 1087
            .|...||:|:|:|.|.|..|:||.:|||. .||.|..|.||:.||:.||.|.||||         
  Fly  1563 CWELKTATIVMMTRLEERTRIKCDQYWPTRGTETYGQIFVTITETQELATYSIRTF--------- 1618

Human  1088 EANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSA 1152
                    ::.::|.::.|||:|..||.|||||||.|....|.|:|:.::.:||.:||::|||||
  Fly  1619 --------QLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQFLRRCRALTPPESGPVIVHCSA 1675

Human  1153 GAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSV 1217
            |.|||||:||||.||:..:.|.::|||..|..||::|..|||||:||:|||||||||.:||.|.|
  Fly  1676 GVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTEDQYIFIHDAILEAIICGVTEV 1740

Human  1218 PASQVRSLYYDMNKL---DPQTNSSQIKEEFRTLNMVTPTLRVEDCS---IALLPRNHEKNRCMD 1276
            ||   |:|:..:.||   :|....|.::.||:.|:.|.     .|.|   .|.||.|..|||.:.
  Fly  1741 PA---RNLHTHLQKLLITEPGETISGMEVEFKKLSNVK-----MDSSKFVTANLPCNKHKNRLVH 1797

Human  1277 ILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVM 1340
            |||.:....:|..|.| |.|:|:||:.:|.|:..||:|..|.|:.:..:||||::.:::.|.|||
  Fly  1798 ILPYESSRVYLTPIHGIEGSDYVNASFIDGYRYRSAYIAAQGPVQDAAEDFWRMLWEHNSTIVVM 1862

Human  1341 LNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDG-YRMVQQFQ 1402
            |..:..  .:.|.||||.....|:   |...|....|.::.....|.:.....:|| .|.|:|||
  Fly  1863 LTKLKEMGREKCFQYWPHERSVRY---QYYVVDPIAEYNMPQYKLREFKVTDARDGSSRTVRQFQ 1924

Human  1403 FLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQ 1467
            |:.|| .:..|.|...|:..|.||.|.:|:: |.:|...|||..|.||||.|..:|||.|.::::
  Fly  1925 FIDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQDGPITVHCSAGVGRSGVFITLSIVLERMQYE 1987

Human  1468 RTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNS 1506
            ..:|||..|:.||:.:|.||...|||.|||..|||||.|
  Fly  1988 GVLDVFQTVRILRSQRPAMVQTEDQYHFCYRAALEYLGS 2026

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRMXP_011524010.1 MAM 22..182 CDD:214533 32/184 (17%)
MAM 27..182 CDD:99706 32/184 (17%)
IG_like 192..278 CDD:214653 17/96 (18%)
ig 192..274 CDD:278476 17/92 (18%)
FN3 282..361 CDD:214495 29/93 (31%)
FN3 383..477 CDD:238020 21/101 (21%)
FN3 499..581 CDD:238020 25/88 (28%)
PTPc 937..1208 CDD:214550 139/271 (51%)
PTPc 964..1208 CDD:238006 129/244 (53%)
PTPc 1240..1502 CDD:214550 99/268 (37%)
PTPc 1270..1502 CDD:238006 89/235 (38%)
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470
FN3 423..514 CDD:238020 22/97 (23%)
FN3 520..610 CDD:238020 12/89 (13%)
FN3 616..707 CDD:238020 17/99 (17%)
FN3 712..810 CDD:238020 30/104 (29%)
FN3 832..907 CDD:238020 18/85 (21%)
FN3 914..1005 CDD:238020 29/116 (25%)
FN3 1012..1101 CDD:238020 18/97 (19%)
fn3 1106..1198 CDD:278470 16/91 (18%)
PTPc 1476..1731 CDD:214550 139/271 (51%)
PTPc 1503..1731 CDD:238006 129/244 (53%)
PTPc 1763..2022 CDD:214550 99/268 (37%)
PTPc 1791..2022 CDD:238006 89/235 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4228
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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