DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRK and Dscam1

DIOPT Version :9

Sequence 1:	NP_001278910.1	Gene:	PTPRK / 5796	HGNCID:	9674	Length:	1462	Species:	Homo sapiens
Sequence 2:	NP_001246162.1	Gene:	Dscam1 / 35652	FlyBaseID:	FBgn0033159	Length:	2038	Species:	Drosophila melanogaster

Alignment Length:	1278	Identity:	241/1278 - (18%)
Similarity:	400/1278 - (31%)	Gaps:	442/1278 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   161 PNEYQVIFEAEVSGGRSGYIAIDDIQVLS---YPCD------------------KSPHFL-RLGD 203
            |.||:.:.:::......|.:.:|:||..:   |.|:                  ..|.|. :|.:
  Fly   763 PGEYKDLKKSDNIRVEEGTLHVDNIQKTNEGYYLCEAINGIGSGLSAVIMISVQAPPEFTEKLRN 827

Human   204 VEVNAGQNATFQCIATGRDAV-----HNKLWLQRRNGEDIPVAQTKNINHRRFAASFRLQEVTKT 263
            .....|:.|..||.|.|...:     .|.:.|..:|.....:.:  .|......:|..::...::
  Fly   828 QTARRGEPAVLQCEAKGEKPIGILWNMNNMRLDPKNDNRYTIRE--EILSTGVMSSLSIKRTERS 890

Human   264 DQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLN-ANSIIGDGPIILKE 327
            |..|:.||..:..||..::...::...|..|.|...|...|.:   :||: |....|:.|:....
  Fly   891 DSALFTCVATNAFGSDDASINMIVQEVPEMPYALKVLDKSGRS---VQLSWAQPYDGNSPLDRYI 952

Human   328 VEYRMTSGSWTETHAVNAPTY----KLWHLDPDTEYEIRVLLTRPGEG--GTGLPGPPLITRTKC 386
            :|::.:..||:|...|..|.:    ::..|.|.|.|.||::    .|.  ||......:...|..
  Fly   953 IEFKRSRASWSEIDRVIVPGHTTEAQVQKLSPATTYNIRIV----AENAIGTSQSSEAVTIITAE 1013

Human   387 AEPMRTPKTLKIAEIQARRIAVDW----------ESLGY-------NITRCHTFNVTICYHYFRG 434
            ..|...|:.:|:..:....:.|.|          |.|||       |....:.|. ||.:....|
  Fly  1014 EAPSGKPQNIKVEPVNQTTMRVTWKPPPRTEWNGEILGYYVGYKLSNTNSSYVFE-TINFITEEG 1077

Human   435 --HN-----------------------------ESKADCLDMDPKAP------------------ 450
              ||                             |.|....:..|..|
  Fly  1078 KEHNLELQNLRVYTQYSVVIQAFNKIGAGPLSEEEKQFTAEGTPSQPPSDTACTTLTSQTIRVGW 1142

Human   451 ------------------------------QH---------VVNHLPPYTNVSLKMILTNPEGRK 476
                                          :|         |::.|..|||.:::::.|...|..
  Fly  1143 VSPPLESANGVIKTYKVVYAPSDEWYDETKRHYKKTASSDTVLHGLKKYTNYTMQVLATTAGGDG 1207

Human   477 ESEETI-IQTDEDVP-GPVPVKSL-QGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538
            .....| .||:.||| .|..||:| .|.:   .|.::|:.|..||||||||.: ||.
  Fly  1208 VRSVPIHCQTEPDVPEAPTDVKALVMGNA---AILVSWRPPAQPNGIITQYTV-YSK-------- 1260

Human   539 PVAGPPQTVSNLWNSTHHVF----MHLHPGTTYQFFIRASTVKGFGPATAINVTTNISAPTLPDY 599
              |...:|.:......|:..    ..|.....|:|::.|||..|.|..:.       |...:|.
  Fly  1261 --AEGAETETKTQKVPHYQMSFEATELEKNKPYEFWVTASTTIGEGQQSK-------SIVAMPS- 1315

Human   600 EGVDASLNETATTITVLLR-----PAQAKGAP------------ISAY---------QIVVEELH 638
            :.|.|.:.....|.|...:     |..|.|||            .||.         .::::.::
  Fly  1316 DQVPAKIASFDDTFTATFKEDAKMPCLAVGAPQPEITWKIKGVEFSANDRMRVLPDGSLLIKSVN 1380

Human   639 PHRTKREAGAMECYQVPVTYQNAMSGGAPYYFAAELPPGNLPEPAPFTVGDNRT---------YQ 694
                :::||...|:.     :|:::..:..:....|.|   |:....|:....|         ::
  Fly  1381 ----RQDAGDYSCHA-----ENSIAKDSITHKLIVLAP---PQSPHVTLSATTTDALTVKLKPHE 1433

Human   695 GFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDRVVKIAGISA 759
            |    ..||..||.::::                 .:....|..||..|..|.     .|.|:..
  Fly  1434 G----DTAPLHGYTLHYK-----------------PEFGEWETSEVSVDSQKH-----NIEGLLC 1472

Human   760 GILVFILL-------------LLVVILIVKKSKLAKKRK--DAMGNTRQ-----------EMTHM 798
            |....:..             :|......:|.||.:|.:  :...|:..           .|:|.
  Fly  1473 GSRYQVYATGFNNIGAGEASDILNTRTKGQKPKLPEKPRFIEVSSNSVSLHFKAWKDGGCPMSHF 1537

Human   799 VNAMDRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDV 863
            |  ::....||             ::.:..|..:..|.......|.|.|..|...||.:|....|
  Fly  1538 V--VESKKRDQ-------------IEWNQISNNVKPDNNYVVLDLEPATWYNLRITAHNSAGFTV 1587

Human   864 PRY------LCEGTESPYQT----GQLHPAIRVADLLQH---INLM------------------- 896
            ..|      :..||.:|...    |.:|..||:...:..   :|.|
  Fly  1588 AEYDFATLTVTGGTIAPLDDGSGHGNVHTRIRLPAWMPEWLDLNFMVPLIATVVVVAVGICVVCV 1652

Human   897 -----KTSDSYGFKEE--YESFFE---GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED 951
                 :..|..|.:::  |:..:.   |..|:.|..:.|   .::..|.|...:..   |.||
  Fly  1653 ALSRRRADDMRGGQKDVYYDVVYNQTMGPGATLDKRRPD---LRDELGYIAPPNRK---LPPV-- 1709

Human   952 DPSSDY------------INANYIDIWLYRDGYQRPSHY---IATQGPVHETVYDFWRMIWQEQS 1001
             |.|:|            :.:|: ..|   |..:.|:.|   .|...|:|...|....
  Fly  1710 -PGSNYNTCDRIKRGRGGLRSNH-STW---DPRRNPNLYEELKAPPVPMHGNHYGHAH------- 1762

Human  1002 ACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCV--EMEPLAEYVVRTFTLERRGYNEIR 1061
                        |..:|:...|   |:...|..|.:...  ||:|......:||.
  Fly  1763 ------------GNAECHYRHPGMEDEICPYATFHLLGFREEMDPTKAMNFQTFP---------- 1805

Human  1062 EVKQFHFTGWPDHG--VPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGA--------------- 1109
                 |..|   |.  ||.||..:|           |...|..||..:|:
  Fly  1806 -----HQNG---HAGPVPGHAGTML-----------PPGHPGHVHSRSGSQSMPRANRYQRKNSQ 1851

Human  1110 -GRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE 1151
             |::..|.......|.|         ||.:..:.||...|.::
  Fly  1852 GGQSSIYTPAPEYDDPA---------NCAEEDQYRRYTRVNSQ 1885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRK	NP_001278910.1	MAM	32..192	CDD:214533	8/33 (24%)
		IG_like	202..288	CDD:214653	17/90 (19%)
		fn3	297..371	CDD:365830	19/78 (24%)
		fn3	488..581	CDD:365830	31/98 (32%)
		PTP_DSP_cys	888..1166	CDD:391942	59/334 (18%)
		Substrate binding. /evidence=ECO:0000250	1105..1111		1/21 (5%)
		R-PTPc-K-2	1252..1457	CDD:350484
Dscam1	NP_001246162.1	Ig	38..130	CDD:299845
		IG	57..133	CDD:214652
		IG_like	267..343	CDD:214653
		Ig	269..340	CDD:143165
		IG_like	353..425	CDD:214653
		IGc2	361..413	CDD:197706
		I-set	433..527	CDD:254352
		IGc2	446..517	CDD:197706
		I-set	533..618	CDD:254352
		IGc2	544..607	CDD:197706
		Ig	641..714	CDD:143165
		IGc2	735..804	CDD:197706	9/40 (23%)
		I-set	819..914	CDD:254352	20/96 (21%)
		Ig	833..921	CDD:299845	18/89 (20%)
		FN3	918..1011	CDD:238020	25/99 (25%)
		FN3	1018..1116	CDD:238020	17/98 (17%)
		FN3	1124..1217	CDD:238020	10/92 (11%)
		FN3	1222..1312	CDD:238020	31/110 (28%)
		Ig	1339..1406	CDD:299845	11/75 (15%)
		FN3	1409..1499	CDD:238020	18/118 (15%)
		FN3	1504..1584	CDD:238020	18/94 (19%)
		Dscam_C	1890..2008	CDD:289151
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000