DRSC/TRiP Functional Genomics Resources

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Protein Alignment PTPRJ and Lar

DIOPT Version :9

Sequence 1:XP_016873572.1 Gene:PTPRJ / 5795 HGNCID:9673 Length:1363 Species:Homo sapiens
Sequence 2:NP_001260594.1 Gene:Lar / 35259 FlyBaseID:FBgn0000464 Length:2032 Species:Drosophila melanogaster


Alignment Length:1444 Identity:323/1444 - (22%)
Similarity:533/1444 - (36%) Gaps:388/1444 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   158 PDPSVATVATGE--NGITQISSTAESFHKQNGTGTPQV---ETNTSEDGESSGANDSLRT----P 213
            |..:.||..||:  .|.|::.|...:...:..:.:..|   |...:.:|:.:|......|    |
  Fly   402 PPSAPATCTTGDFSFGGTKMESAPRNVQVRTLSSSTMVITWEPPETPNGQVTGYKVYYTTNSNQP 466

Human   214 EQGSNG--TDGASQKTPSSTEPIPVSDLRV-ALTGVRKAALSWSNGNGTASCRVLLE------SI 269
            |...|.  .|.:...|.|...|..:..:|| |.|         |.|.|..|..|.::      |.
  Fly   467 EASWNSQMVDNSELTTVSELTPHAIYTVRVQAYT---------SMGAGPMSTPVQVKAQQGVPSQ 522

Human   270 GSHEELTQDSRLQVNISGLKP-GVQYNINPYLLQSNKTKGDPLGTEGGLDASNTERSRAGSPTAP 333
            .|:...|......|.:...|| ....||..|.|..|.|.           |:.....|..:..|.
  Fly   523 PSNFRATDIGETAVTLQWTKPTHSSENIVHYELYWNDTY-----------ANQAHHKRISNSEAY 576

Human   334 VHDESLVGPVDPSSGQQSRDTEVLLVGLEPGTRYN--ATVYSQAANGTEGQPQAIEFRTNAIQVF 396
            ..|                       ||.|.|.|.  ....||...|....|..:..:.......
  Fly   577 TLD-----------------------GLYPDTLYYIWLAARSQRGEGATTPPIPVRTKQYGAPPR 618

Human   397 DVTAVNISATSLTLIWKVSDNESSSN--YTYK---IHVAGETD-SSNLNVSEPRAVIPGLRSSTF 455
            ::||:..|:|:::|.|.....|.|:.  ..||   :.|..|.| ::.:.::....|:..|:..|.
  Fly   619 NITAIATSSTTISLSWLPPPVERSNGRIIYYKVFFVEVGREDDEATTMTLNMTSIVLDELKRWTE 683

Human   456 YNITVC------------PVL----GDIEGTPGFLQVHTPPVPVSDFRVTVVSTTEIGLAWS--- 501
            |.|.|.            |::    .|:.|.|            .|.:.|.:::|.|.::|.   
  Fly   684 YKIWVLAGTSVGDGPRSHPIILRTQEDVPGDP------------QDVKATPLNSTSIHVSWKPPL 736

Human   502 ----SHDAESFQMH---ITQEGAG--NS--RVEITTNQSIIIGGLFPGTKYCFEIVPKGPNGTEG 555
                :.....:.:|   :..||.|  |.  :.::.......:.||.|.|||..::......|...
  Fly   737 EKDRNGIIRGYHIHAQELRDEGKGFLNEPFKFDVVDTLEFNVTGLQPDTKYSIQVAALTRKGDGD 801

Human   556 ASRTVCNRTVPSAVFDIHVVYVTTTE------MWLDWKSP------------------------- 589
            .|..:..:| |..|.....|.:...|      :.|:|:.|                         
  Fly   802 RSAAIVVKT-PGGVPVRPTVSLKIMEREPIVSIELEWERPAQTYGELRGYRLRWGVKDQALKEEM 865

Human   590 --------------DGASEYVYHLVIESKHGSNHTSTYDKAI----TLQGLIPGTLYNITI---S 633
                          :...||.:.:.     ||||.....:.:    |.:|...|...||||   :
  Fly   866 LSGPQMTKKRFDNLERGVEYEFRVA-----GSNHIGIGQETVKIFQTPEGTPGGPPSNITIRFQT 925

Human   634 PEVDHVWGDPNSTAQYTRPSNVSNIDV------------STNTTAATLSWQNFDD---------- 676
            |:|..|..|| .|.:: |...::..||            ..|.|.....:.|.::          
  Fly   926 PDVLCVTWDP-PTREH-RNGIITRYDVQFHKKIDHGLGSERNMTLRKAVFTNLEENTEYIFRVRA 988

Human   677 -----ASPTYSYCLLIE------------KAGNSSNAT-----QVVTD----------------- 702
                 |.| :|..|::|            :|..:|..|     :.||.                 
  Fly   989 YTKQGAGP-FSDKLIVETERDMGRAPMSLQAEATSEQTAEIWWEPVTSRGKLLGYKIFYTMTAVE 1052

Human   703 ---------IGITD-ATVTELIPGSSYTVEIFAQVGDGIKSLEPGRKSFCTD--------PASMA 749
                     :|:|: |.:..|...:.|.|.|.|:..:|:     ||.|....        |.::.
  Fly  1053 DLDDWQTKTVGLTESADLVNLEKFAQYAVAIAARFKNGL-----GRLSEKVTVRIKPEDVPLNLR 1112

Human   750 SFDCEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSSENGTEYRT---------- 804
            :.|...    .::.|.|: ||........::|..|.......:..|.......|.          
  Fly  1113 AHDVST----HSMTLSWS-PPIRLTPVNYKISFDAMKVFVDSQGFSQTQIVPKREIILKHYVKTH 1172

Human   805 EVTYLNFSTSYNISITTV-SCGKMAAPTRNTCTTGITDPPP---PD--GSPNITSVSHNSVKVKF 863
            .:..|:..|:||::::.: |......||:.|.||.:..|.|   ||  |     .|:...:.|..
  Fly  1173 TINELSPFTTYNVNVSAIPSDYSYRPPTKITVTTQMAAPQPMVKPDFYG-----VVNGEEILVIL 1232

Human   864 SGFEASHGPIKAYAVILTTGEAG--HPSADVLKYTYEDFKKGASD------TYVTYLIRTEEKGR 920
            ......:|||..|.:::...:..  |...|  ::..:|...|.:.      .|:.          
  Fly  1233 PQASEEYGPISHYYLVVVPEDKSNLHKIPD--QFLTDDLLPGRNKPERPNAPYIA---------- 1285

Human   921 SQSLSEVLKYEIDVGNESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYV-SFS 984
            ::.....:.:...:|:......:.|.|||....||..|            :.::|..:.:: :.|
  Fly  1286 AKFPQRSIPFTFHLGSGDDYHNFTNRKLEREKRYRIFV------------RAVVDTPQKHLYTSS 1338

Human   985 RYSDAVSL------------------PQDPGV----------ICGAVFGCIFGALVIVTVGGFIF 1021
            .:|:.:||                  |.:|.|          |...|...:....::.|....:.
  Fly  1339 PFSEFLSLDMREAPPGERPHRPDPNWPAEPEVSVNRNKDEPEILWVVLPLMVSTFIVSTALIVLC 1403

Human  1022 WRKKRKD-----------------------AKNNEVSFSQIKPKKSKLIR-----VENFEAYFKK 1058
            ..|:|:.                       ..::.|...::..:...:|.     :..|..:.::
  Fly  1404 VVKRRRQPCKTPDQAAVTRPLMAADLGAGPTPSDPVDMRRLNFQTPGMISHPPIPISEFANHIER 1468

Human  1059 QQADSNCGFAEEYEDLKLVGISQPKYA-----AELAENRGKNRYNNVLPYDISRVKL-SVQTHST 1117
            .:::.|..|::|||.:      :|...     :.|..|:.||||.||..||.|||:| :|:....
  Fly  1469 LKSNDNQKFSQEYESI------EPGQQFTWDNSNLEHNKSKNRYANVTAYDHSRVQLPAVEGVVG 1527

Human  1118 DDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQGRTKCEEYWPSK 1182
            .|||||||..||.....::||||||..|..|||||.||.....|:|:|:..|:.|.||::|||::
  Fly  1528 SDYINANYCDGYRKHNAYVATQGPLQETFVDFWRMCWELKTATIVMMTRLEERTRIKCDQYWPTR 1592

Human  1183 QAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYL 1247
            ..:.||.|.|.:|....|..::||.|.:.....::...::|..||:||||||||.....:.|   
  Fly  1593 GTETYGQIFVTITETQELATYSIRTFQLCRQGFNDRREIKQLQFTAWPDHGVPDHPAPFLQF--- 1654

Human  1248 VRDYMKQSPPES-PILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDLRMHRPLMVQTE 1311
            :|.....:|||| |::|||||||||||.:|.||.::.::::|..:|:||.|..||..|..|||||
  Fly  1655 LRRCRALTPPESGPVIVHCSAGVGRTGCYIVIDSMLERMKHEKIIDIYGHVTCLRAQRNYMVQTE 1719

Human  1312 DQYVFLNQCVLDIV 1325
            |||:|::..:|:.:
  Fly  1720 DQYIFIHDAILEAI 1733

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRJXP_016873572.1 None
LarNP_001260594.1 Ig 35..129 CDD:299845
I-set 36..129 CDD:254352
IG_like 146..227 CDD:214653
Ig 159..228 CDD:299845
I-set 234..318 CDD:254352
Ig3_RPTP_IIa_LAR_like 249..317 CDD:143216
fn3 324..404 CDD:278470 1/1 (100%)
FN3 423..514 CDD:238020 22/99 (22%)
FN3 520..610 CDD:238020 25/123 (20%)
FN3 616..707 CDD:238020 20/90 (22%)
FN3 712..810 CDD:238020 20/109 (18%)
FN3 832..907 CDD:238020 9/79 (11%)
FN3 914..1005 CDD:238020 21/93 (23%)
FN3 1012..1101 CDD:238020 17/93 (18%)
fn3 1106..1198 CDD:278470 15/96 (16%)
PTPc 1476..1731 CDD:214550 111/263 (42%)
PTPc 1503..1731 CDD:238006 104/230 (45%)
PTPc 1763..2022 CDD:214550
PTPc 1791..2022 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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