DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PTPRJ and Ptp4E

DIOPT Version :9

Sequence 1:XP_016873572.1 Gene:PTPRJ / 5795 HGNCID:9673 Length:1363 Species:Homo sapiens
Sequence 2:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1558 Identity:405/1558 - (25%)
Similarity:627/1558 - (40%) Gaps:331/1558 - (21%)


- Green bases have known domain annotations that are detailed below.


Human    40 PPRGSRARLRRVAAAAAAAAMSPGKPGAGGAGTRRTGWRRR---------RRRRRQEAATTVPGL 95
            ||.....:||    ::.:|.::...||:|    |.:|:|.|         .|....|...|:...
  Fly   153 PPANLSVQLR----SSKSAFITWRPPGSG----RYSGFRIRVLGLTDLPFERSYSLEGNETLQLS 209

Human    96 GR--TAGPDSRVR--GTFQGARGMKPAAREARLPPRSPG--LRWALPLLLLLLRLGQILCAGGTP 154
            .:  |.|...:|:  ..:||...:...:|.....|.:||  :.|......||     :|.....|
  Fly   210 AKELTPGGSYQVQAYSVYQGKESVAYTSRNFTTKPNTPGKFIVWFRNETTLL-----VLWQPPFP 269

Human   155 SPI---------PDPSVATVATGENGITQISSTAESFHKQNGTGTP---QVETNTSEDGESSGAN 207
            :.|         ||.::.:|...|.. .:....|::..|....|..   .|:| .|||..||...
  Fly   270 AGIYTHYRVSITPDDAIQSVLYVERE-GEPPGPAQAAFKGLVPGREYNISVQT-VSEDETSSVPT 332

Human   208 DS--LRTPEQGSNGTDGASQKTPSS----TEP-----------IPVSDLRVALTGVRKAALSWSN 255
            .:  |..||:..|.|...:..|.||    .||           :.:|..| .:..|.:||    |
  Fly   333 TARYLTVPERVLNVTFDEAYTTSSSFRVRWEPPRTYSEFDAYQVMLSTSR-RIFNVPRAA----N 392

Human   256 GNGT-----------------------------ASCRVLL-----ESIGSHEELTQDSRLQVNIS 286
            |:..                             ||..|.|     .|:|...: .:.:.|.::..
  Fly   393 GDSVYFDYPDILEPGRTYEVVVKTIADNVNSWPASGEVTLRPRPVRSLGGFLD-DRSNALHISWE 456

Human   287 GLKPGVQ--YNINPYLLQSNKTKGD---PLGTEG-----------------------------GL 317
            ..:.|.|  |.|: |..|:|.::..   |:..|.                             |:
  Fly   457 PAETGRQDSYRIS-YHEQTNASEVPAPFPVAAESQITTNLTEYTLDSLLAGRRYLIAVQALSKGV 520

Human   318 DASNTERSRAGSPTAPVHDE--------SLVGPVDPSSGQQ------------------SRDTEV 356
            .::.::.:|...|.||:..|        .|....|.:|.|.                  :.:|.:
  Fly   521 ASNASDITRYTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREERTMATNETSL 585

Human   357 LLVGLEPGTRYNATVYSQAANGTEGQPQAIEFRTNAIQVF-----DVTAVNISATSLTLIWKVSD 416
            .:..|.||:.|...|:: .::|...:|.:. |:.    ||     ::|...:....:.|.|:..:
  Fly   586 TIHYLHPGSGYEVKVHA-ISHGVRSEPHSY-FQA----VFPKPPQNLTLQTVHTNLVVLHWQAPE 644

Human   417 NESSSNYTYKIHVAGETDS------SNLNVSEPRAVIPGLRSSTFYNITVCPVLGDIEGT-PGFL 474
            ....|.|.    |...||:      |.|:.:|.|  |..:.....|.:.|..|...:|.. |..|
  Fly   645 GSDFSEYV----VRYRTDASPWQRISGLHENEAR--IKDMHYGERYLVQVNTVSFGVESPHPLEL 703

Human   475 QVHTPPVPVSDFRVTVVSTTEIGLAWSSHDAESFQMHI---------TQEGAGNSRVEI------ 524
            .|..||.|||:. |.:|.:..:.|.|...|.     |:         |.|   ..|||.      
  Fly   704 NVTMPPQPVSNV-VPLVDSRNLTLEWPRPDG-----HVDFYTLKWWPTDE---EDRVEFKNVTQL 759

Human   525 ----TTNQSIIIGGLFPGTKYCFEIVPKGPNGTEGASRTVCNRTVPSAVFDIHVVYV-------- 577
                :.:..|.|..|.||.:|.|| |....||....:..:..||:|....|:.:...        
  Fly   760 EDLSSPSVRIPIEDLSPGRQYRFE-VQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDE 823

Human   578 TTTEMWLDWKSPDGASEY-VYHL-----VIESKHG-SNHTSTYDKAITLQGLIPGTLYNITISPE 635
            |.|..:.  .:|..::.: :|..     .|:.|.. :|.|   ::.::..||.||.|||:|:...
  Fly   824 TITLSYT--PTPADSTRFDIYRFSMGDPTIKDKEKLANDT---ERKLSFSGLTPGKLYNVTVWTV 883

Human   636 VDHVWGDPNSTAQYTRPSNVSNID-VSTNTTAATLSWQNFDDASPTYSYC-LLIEKAGNSSNATQ 698
            ...|...|........|..:|::. :.......||.|     .:|...|. ..::.......|.|
  Fly   884 SGGVASLPVQRLYRLHPLPISDLKAIQVAAREITLHW-----TAPAGEYTDFELQYLSADEEAPQ 943

Human   699 VVTDI-GITDATVTELIPGSSYTVEI-----------FAQVGDG--IKSLEPGRKSFCTDPASMA 749
            ::.:: ..|:.|:..|.|..:||..:           ||.|...  ::|..|...|:.|..|...
  Fly   944 LLQNVTKNTEITLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISASYQTLTAPPG 1008

Human   750 SFD----CEVVPKEPALVLKWTCPPGANAGFELEVSSGAWNNATHLESCSS----ENGTEYRTEV 806
            ..|    .:|.|.|  :..:|:..|....| .::.......||......||    .|.|:  .::
  Fly  1009 KVDYFQPSDVQPGE--VTFEWSLEPAEQHG-PIDYFRITCQNADDAADVSSYEFPVNATQ--GKI 1068

Human   807 TYLNFSTSYNISITTVSCGKMAAPTRNTCTTGITDPPPPDGSPNITSVSHNSVKVKFS----GFE 867
            ..|.....|...|...|.....|...:..|..|..||.|:.|.....||..|..::.|    .|.
  Fly  1069 DGLVPGNHYIFRIQAKSALGYGAEREHIQTMPILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFS 1133

Human   868 ASHGPIKAYAVILTTGEAGHPSA-------DVLKYT----YEDFKKGASDTYVTYLIRTEEKGRS 921
            .:||.:::|.:|:......:.|.       ||..||    |:     |.:.|..:|  |....|.
  Fly  1134 NAHGMVRSYTIIIAEDVGKNASGLEMPSWQDVQAYTVWLPYQ-----AIEPYNPFL--TSNGSRK 1191

Human   922 QSLSEVLKYEIDVGN-ESTTLGYYNGKLEPLGSYRACVAGFTNITFHPQNKGLIDGAESYVSFSR 985
            .|| |...:.|...| :....||.||.|....:||..:..||:              |...:.:.
  Fly  1192 SSL-EAEHFTIGTANCDKHQAGYCNGPLRAGTTYRIKIRAFTD--------------EDKFTDTV 1241

Human   986 YSDAVSLPQ-DPGVICGAVFGCIFGALVIVTV---GGFIFWRKKRKDAKNNE----VSFSQIKPK 1042
            ||..::..: |..::...|...:..|:|:|.|   ......|:..|.|:..:    :....|.|.
  Fly  1242 YSSPITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAALPEGYITPN 1306

Human  1043 KSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLPYDISR 1107
            :.  :.|::|..:::...|||:..|:||:|:||.||..|....|.|..||.|||:.|:||||.||
  Fly  1307 RP--VHVKDFSEHYRIMSADSDFRFSEEFEELKHVGRDQACSFANLPCNRPKNRFTNILPYDHSR 1369

Human  1108 VKLS-VQTHSTDDYINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAIIMLTKCVEQG 1171
            .||. |......||||||||||::|.::||.|||||.:|.::||||.||.|..||:|||:|.|:|
  Fly  1370 FKLQPVDDDDGSDYINANYMPGHNSPREFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKG 1434

Human  1172 RTKCEEYWP-SKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESHPLRQFHFTSWPDHGVP 1235
            |.||::||| .:.|..||||.|.:..:....:|:|.:|.|.  :..||..:|.||||:|||.|||
  Fly  1435 REKCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS--RNCESRIMRHFHFTTWPDFGVP 1497

Human  1236 DTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAIDRLIYQIENENTVDVYGIVYDL 1300
            :....|:.|....||.:  .....||:|||||||||:|||||:||::..|...:.||::|||:.:
  Fly  1498 EPPQSLVRFVRAFRDVI--GTDMRPIIVHCSAGVGRSGTFIALDRILQHIHKSDYVDIFGIVFAM 1560

Human  1301 RMHRPLMVQTEDQYVFLNQCVLDIVRSQKDSKVDLI-------YQNTTAMTIYENLAPVTTFG 1356
            |..|..|||||.|||.::||:|.::..::....|.:       |:.|   .||....|.|..|
  Fly  1561 RKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVT---KIYLERQPQTKMG 1620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PTPRJXP_016873572.1 None
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020 21/96 (22%)
fn3 247..328 CDD:278470 20/87 (23%)
fn3 343..417 CDD:278470 14/78 (18%)
fn3 443..525 CDD:278470 11/83 (13%)
FN3 548..611 CDD:238020 11/63 (17%)
FN3 620..706 CDD:238020 19/91 (21%)
fn3 708..796 CDD:278470 27/97 (28%)
fn3 824..886 CDD:278470 16/66 (24%)
fn3 902..978 CDD:278470 14/80 (18%)
fn3 1013..1092 CDD:278470 16/83 (19%)
UP_III_II 1106..>1248 CDD:297589 39/163 (24%)
PTPc 1329..1582 CDD:214550 129/256 (50%)
PTPc 1355..1582 CDD:238006 116/230 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 285 1.000 Domainoid score I1621
eggNOG 1 0.900 - - E2759_KOG0791
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D16347at33208
OrthoFinder 1 1.000 - - FOG0001181
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR19134
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3031
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.910

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