Protein Alignment PTPRG and CG42327

DIOPT Version :10

• Sequence 1: XP_016862450.1
• Gene: PTPRG / 5793
• HGNCID: 9671
• Length: 1485
• Species: Homo sapiens
• Sequence 2: NP_001036706.2
• Gene: CG42327 / 41401
• FlyBaseID: FBgn0259227
• Length: 1429
• Species: Drosophila melanogaster
• Alignment Length: 1125
• Identity: 247/1125 - (21%)
• Similarity: 394/1125 - (35%)
• Gaps: 345/1125 - (30%)

Human   267 HEKETFLD---------------PFVLRDLLPASLGSYYRYTGSLT--TPPCSEIVEWIVFRRPV 314
            |:::..||               .||:|..|.|:.|:....|.:|.  |...|:|...:
  Fly   395 HKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATEGATQATTEALVEETHSKSDITVGL------ 453

Human   315 PISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLG 379
                             :||:|.:...:.:.  |.....|..::.:.||       |..||.||.
  Fly   454 -----------------EQDNVTTARTMPST--PDPGSMDLNMTTTTVR-------TQQLEVPLV 492

Human   380 TEASKVCSSPPIHMKVQPLNQT---------------------ALQVSWSQPETIYHPPIMNYMI 423
            .:.|...::..|....:|..:|                     ..:|..:|.|      ::|...
  Fly   493 KKMSDAANAKLIEAVTEPQRETEAATEAATFVTLPEKLATFGITARVDSTQTE------LLNVTT 551

Human   424 SYSWTKNEDEKEKTFTKDSDKDLKAT---------ISHVSPDSLYLFRVQAVCRNDMR--SDFSQ 477
            :.:.|:: .|..|..:.|:...:.:|         :.||:|:            .||.  :..:.
  Fly   552 AAAATES-GEMSKANSTDTLSAMTSTTTTTARPMSVEHVTPE------------QDMEAATSLAT 603

Human   478 TMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVS----------- 531
            |....:.||.. ..|.......|..|.|::|..|..:|.::|..:..:..:..|
  Fly   604 TAATSSGTTEA-AATSSTTAATPVVSEAATAAEASATSEATTAATLSVATTAASTTEIAMKATQI 667

Human   532 ---------------MATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSF------PSTVWP 575
                           :||...|.|. ..||.|||..:|....:...|...:|.      .||...
  Fly   668 SNIRDDNDDNSNDVIVATTKFPESE-QAATTASVEPTTTSVSVRVAGEVSTSIRPEIIVTSTRNS 731

Human   576 TRLPTAASASKQAARPVL---------ATTEALASPGPDG--DSSPTKDGEGTEEGEKDEK--SE 627
            |.:.|:.||: ..|.|..         ...||:.....||  |::..:..|.|:....:..  :|
  Fly   732 TIVDTSTSAT-SVATPTQTEIAQISNEVNLEAVTVKTRDGLSDTNELRTAEKTDNAVNNSVAITE 795

Human   628 SEDG-----------------------EREHEED------GEKDSEKKEKSGVTHAAEERNQTEP 663
            |:.|                       .:|||..      ||...|....:.....|...:::..
  Fly   796 SDLGALATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPPESTTPAAPATVAVATDESTA 860

Human   664 SPTPSSPNRTAEGGHQTI-PGHEQDHTAVPTDQ-------------TGGRRDAGPGLDPDMVTST 714
            :|       .|.||.:.: .|...|...|..:|             |.....|.........|:|
  Fly   861 AP-------AATGGQEIVREGQHHDGQQVADEQDTEQQLAKTTMAVTTTTTSATTTTTSTTTTTT 918

Human   715 QVPPTATEEQ------------YAGSDPKRP------EMPSKKPMSRGDRFSEDSRFITVNPAEK 761
            :.|.|.|..|            ...:.|..|      .:.|....|......|.:...|.:|:|.
  Fly   919 ETPLTTTTMQPVEISLLDDSTTTTTTTPAPPVYFESSTVASTTIRSSTTMLPETTTASTQSPSEM 983

Human   762 NTSGMISRPAPGRMEW-------------IIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGF 813
            ..:.|  .|.|..::.             :|..|.||.:..|.||||:|.|...|  .:.|...:
  Fly   984 PPTFM--APYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYLMR--KRQKQTSY 1044

Human   814 PRRFREVP-------------SSGERGE--KGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPD 863
            .:|.|.|.             |...:|.  :.|::.:..|.|   |..|.|            .:
  Fly  1045 GQRCRPVSLDAYSLDNVSVLGSVRRKGRDMRASKRTYGNAAF---DDPSLR------------HN 1094

Human   864 DMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDH 928
            .:.|..:.:||:...:::        |:|.:|.:..|..:...     |..:.||||.|::....
  Fly  1095 LLTASELARFVERRSDVF--------EEFRDVPQIIARADEVP-----PGCEDKNRYANVIPLPE 1146

Human   929 SRVKLRPLPGKDSKHSDYINANYVDGYNKA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITN 992
            :||.|: ..|.|.| ::|||||||.|...| ..|||.|.||:||..|||||||||.:.:|:..|:
  Fly  1147 TRVVLQ-RQGDDDK-TEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATD 1209

Human   993 LVEKGRRKCDQYWP----TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQ 1053
            |.|.|..:|.:|.|    .:|...||:..||||..::...|.:      :|.|.|...|     :
  Fly  1210 LSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAI------STLVLKRVDG-----E 1263

Human  1054 NERVVIQYHYTQWPDMGVPEYALPVLTFV--RRSS------------------------------ 1086
            ..|.:..|.| :||:.|||....|::..:  .|||
  Fly  1264 ESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKA 1327

Human  1087 -----------------AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIK-DKSTVNVLGFLK 1133
                             :....:.||:.||||.|.|||||.|..|..::.:: .|.:|::...:.
  Fly  1328 EAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVY 1392

Human  1134 HIRTQRNYLVQTEEQYIFIH 1153
            ::|..|...|||:|||.||:
  Fly  1393 YVRRGRASAVQTKEQYEFIY 1412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PTPRG	XP_016862450.1	alpha_CARP_receptor_like	67..359	CDD:239396	19/108 (18%)
		FN3	388..478	CDD:238020	17/121 (14%)
		PHA03169	<584..>742	CDD:223003	39/231 (17%)
		R-PTPc-G-1	888..1161	CDD:350505	100/321 (31%)
		R-PTP-G-2	1245..1449	CDD:350508
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:214550	95/293 (32%)