DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PTPRG and CG42327

DIOPT Version :9

Sequence 1:	XP_016862450.1	Gene:	PTPRG / 5793	HGNCID:	9671	Length:	1485	Species:	Homo sapiens
Sequence 2:	NP_001036706.2	Gene:	CG42327 / 41401	FlyBaseID:	FBgn0259227	Length:	1429	Species:	Drosophila melanogaster

Alignment Length:	1125	Identity:	247/1125 - (21%)
Similarity:	394/1125 - (35%)	Gaps:	345/1125 - (30%)

- Green bases have known domain annotations that are detailed below.

Human   267 HEKETFLD---------------PFVLRDLLPASLGSYYRYTGSLT--TPPCSEIVEWIVFRRPV 314
            |:::..||               .||:|..|.|:.|:....|.:|.  |...|:|...:
  Fly   395 HKEKNLLDWMNIAMLPLTPENRTEFVVRTTLDATEGATQATTEALVEETHSKSDITVGL------ 453

Human   315 PISYHQLEAFYSIFTTEQQDHVKSVEYLRNNFRPQQRLHDRVVSKSAVRDSWNHDMTDFLENPLG 379
                             :||:|.:...:.:.  |.....|..::.:.||       |..||.||.
  Fly   454 -----------------EQDNVTTARTMPST--PDPGSMDLNMTTTTVR-------TQQLEVPLV 492

Human   380 TEASKVCSSPPIHMKVQPLNQT---------------------ALQVSWSQPETIYHPPIMNYMI 423
            .:.|...::..|....:|..:|                     ..:|..:|.|      ::|...
  Fly   493 KKMSDAANAKLIEAVTEPQRETEAATEAATFVTLPEKLATFGITARVDSTQTE------LLNVTT 551

Human   424 SYSWTKNEDEKEKTFTKDSDKDLKAT---------ISHVSPDSLYLFRVQAVCRNDMR--SDFSQ 477
            :.:.|:: .|..|..:.|:...:.:|         :.||:|:            .||.  :..:.
  Fly   552 AAAATES-GEMSKANSTDTLSAMTSTTTTTARPMSVEHVTPE------------QDMEAATSLAT 603

Human   478 TMLFQANTTRIFQGTRIVKTGVPTASPASSADMAPISSGSSTWTSSGIPFSFVS----------- 531
            |....:.||.. ..|.......|..|.|::|..|..:|.::|..:..:..:..|
  Fly   604 TAATSSGTTEA-AATSSTTAATPVVSEAATAAEASATSEATTAATLSVATTAASTTEIAMKATQI 667

Human   532 ---------------MATGMGPSSSGSQATVASVVTSTLLAGLGFGGGGISSF------PSTVWP 575
                           :||...|.|. ..||.|||..:|....:...|...:|.      .||...
  Fly   668 SNIRDDNDDNSNDVIVATTKFPESE-QAATTASVEPTTTSVSVRVAGEVSTSIRPEIIVTSTRNS 731

Human   576 TRLPTAASASKQAARPVL---------ATTEALASPGPDG--DSSPTKDGEGTEEGEKDEK--SE 627
            |.:.|:.||: ..|.|..         ...||:.....||  |::..:..|.|:....:..  :|
  Fly   732 TIVDTSTSAT-SVATPTQTEIAQISNEVNLEAVTVKTRDGLSDTNELRTAEKTDNAVNNSVAITE 795

Human   628 SEDG-----------------------EREHEED------GEKDSEKKEKSGVTHAAEERNQTEP 663
            |:.|                       .:|||..      ||...|....:.....|...:::..
  Fly   796 SDLGALATAVETNPTTTNSLLSDVSKLSKEHESSLETNNIGEAPPESTTPAAPATVAVATDESTA 860

Human   664 SPTPSSPNRTAEGGHQTI-PGHEQDHTAVPTDQ-------------TGGRRDAGPGLDPDMVTST 714
            :|       .|.||.:.: .|...|...|..:|             |.....|.........|:|
  Fly   861 AP-------AATGGQEIVREGQHHDGQQVADEQDTEQQLAKTTMAVTTTTTSATTTTTSTTTTTT 918

Human   715 QVPPTATEEQ------------YAGSDPKRP------EMPSKKPMSRGDRFSEDSRFITVNPAEK 761
            :.|.|.|..|            ...:.|..|      .:.|....|......|.:...|.:|:|.
  Fly   919 ETPLTTTTMQPVEISLLDDSTTTTTTTPAPPVYFESSTVASTTIRSSTTMLPETTTASTQSPSEM 983

Human   762 NTSGMISRPAPGRMEW-------------IIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGF 813
            ..:.|  .|.|..::.             :|..|.||.:..|.||||:|.|...|  .:.|...:
  Fly   984 PPTFM--APYPNELDHMQTNAQDNGTDVNVIIAITVSVIGVVALILLVAFLYLMR--KRQKQTSY 1044

Human   814 PRRFREVP-------------SSGERGE--KGSRKCFQTAHFYVEDSSSPRVVPNESIPIIPIPD 863
            .:|.|.|.             |...:|.  :.|::.:..|.|   |..|.|            .:
  Fly  1045 GQRCRPVSLDAYSLDNVSVLGSVRRKGRDMRASKRTYGNAAF---DDPSLR------------HN 1094

Human   864 DMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDH 928
            .:.|..:.:||:...:::        |:|.:|.:..|..:...     |..:.||||.|::....
  Fly  1095 LLTASELARFVERRSDVF--------EEFRDVPQIIARADEVP-----PGCEDKNRYANVIPLPE 1146

Human   929 SRVKLRPLPGKDSKHSDYINANYVDGYNKA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITN 992
            :||.|: ..|.|.| ::|||||||.|...| ..|||.|.||:||..|||||||||.:.:|:..|:
  Fly  1147 TRVVLQ-RQGDDDK-TEYINANYVRGPRDAPNYYIACQAPLESTTSDFWRMIWEQQSRVIIQATD 1209

Human   993 LVEKGRRKCDQYWP----TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQ 1053
            |.|.|..:|.:|.|    .:|...||:..||||..::...|.:      :|.|.|...|     :
  Fly  1210 LSENGIERCAEYLPPSATLDNHSSYGDYQVTLKHREVKDRYAI------STLVLKRVDG-----E 1263

Human  1054 NERVVIQYHYTQWPDMGVPEYALPVLTFV--RRSS------------------------------ 1086
            ..|.:..|.| :||:.|||....|::..:  .|||
  Fly  1264 ESRELTHYWY-KWPEAGVPAEEAPIIAMLLEARSSLKSYSLEQANELREKSATLETSMDADGSKA 1327

Human  1087 -----------------AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIK-DKSTVNVLGFLK 1133
                             :....:.||:.||||.|.|||||.|..|..::.:: .|.:|::...:.
  Fly  1328 EAGSTSSHEINGNISSRSGTRSQQGPLTVHCSPGTGRTGTIIASDMAIRSLETPKRSVDIPQLVY 1392

Human  1134 HIRTQRNYLVQTEEQYIFIH 1153
            ::|..|...|||:|||.||:
  Fly  1393 YVRRGRASAVQTKEQYEFIY 1412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PTPRG	XP_016862450.1	None
CG42327	NP_001036706.2	PTPc	1134..1415	CDD:238006	95/293 (32%)
CG42327	NP_001036706.2	Y_phosphatase	1134..1415	CDD:278528	95/293 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900